Role of CARD9 in Health and Diseases
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: 15 August 2026 | Viewed by 56
Special Issue Editors
Interests: TRIM Proteins; HSV infection; innate immunity; autophagy; virology; ER stress; cell signaling
Special Issue Information
Dear Colleagues,
Caspase Recruitment Domain-containing protein 9 (CARD9) is an adaptor protein primarily classified as a CARD-containing protein, specifically within the CC-CARD (coiled-coil CARD) subfamily, and is reported to be primarily expressed in myeloid cells, like macrophages, dendritic cells (DCs), and neutrophils. CARD9 orchestrates immunological responses by assembling immune complexes that facilitate pattern recognition receptors (PRRs) to trigger a signaling cascade, thereby activating innate immunity in response to infections. CARD9 activity has been linked to a variety of cellular functions, including autophagy, ROS generation, apoptosis, and many others. Studies are currently deciphering the mechanistic details of CARD9 functions in apoptosome and inflammasome formation to determine the outcome of apoptosis signaling and the innate immune response. Similarly, the multifaceted involvement of CARD9 in autophagy directs distinct outcomes in response to diverse stimuli. Interestingly, the molecular players involved in determining the composition and function of gut microbiota leading to the intestinal inflammation remain elusive. The functional activity of CARD9 proteins is also regulated by various post-translational modifications like phosphorylation and ubiquitination that can serve as molecular switches. The generation of CARD9 knockouts in cells and animals using CRISPR technology has significantly enhanced our comprehension of CARD9 activities. The intricate roles of CARD9 in various infectious and non-infection contexts suggest CARD9 to be a druggable target. This Special Issue will examine innovative facets of CARD9 function concerning infection, inflammation, and cancer. Recent comprehensive research may assist in identifying innovative techniques to regulate CARD9 activity for medicinal purposes.
Dr. Zuberwasim Sayyad
Dr. Nikhil Sharma
Guest Editors
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Keywords
- CARD9
- innate immunity
- pattern recognition receptors
- autophagy
- apoptosis
- inflammasome
- reactive oxygen species
- post-translational modifications
- gut microbiota
- inflammation and cancer
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