Editorial Board Members’ Collection Series: Pathology of Cancer and Cardiovascular Disease

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 31 August 2025 | Viewed by 4134

Special Issue Editors


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Institute of Biomedical and Biomolecular Science (IBBS), School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK
Interests: mechanistic investigations into pathology of cancer and cardiovascular disease; diet and lifestyle intervention of cancer; cardiovascular disease and diabetes

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Paediatric Neuro-Oncology Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK
Interests: CNS tumours; neurobiology; blood–brain barrier; neurosciences; neurodevelopment; epigenetics; gene regulation; tumour cell invasion; angiogenesis
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Department of Angio-Cardio-Neurology, IRCCS Neuromed, 86077 Pozzilli, Italy
Interests: cardiovascular diseases; autophagy; nutraceuticals; stroke; mitochondrial dysfunction
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Special Issue Information

Dear Colleagues,

Cardiovascular disease (CVD) and cancer are leading causes of death globally. In 2020, the World Health Organization reported an estimation of 19.1 and 10 million deaths from CVD and cancer, respectively. In spite of the known preventable risk factors for both conditions, the screening programmes for early detection and state-of-the-art treatments that have recently become available, the incidence continues to rise. The clinical presentation of these chronic conditions can be different. However, there is an overlap of risk factors such as unhealthy diet, smoking, excess consumption of alcohol, inactivity, socioeconomic status, obesity and biological mechanisms, such as activated nuclear factor kappa B, oxidative stress and chronic inflammation. Interestingly, recently, a causal relationship between the gut microbiota, CVD and cancer has also been highlighted, though this is yet to be further researched.

The aim of this Special Issue is to provide a most recent update on the advances in the field of cancer and CVD pathology, focusing on early detection and diagnosis, including a better understanding of the factors involved in microbiome-mediated mechanisms and in biomarkers for early detection.

This Special Issue on cancer and CVD invites but is not limited to the following topics:

  • Diagnostic pathology of cancer and CVD;
  • Novel molecular mechanisms of cancer and CVD development;
  • Diet and lifestyle interventions for Cancer and Cardiovascular disease;
  • Gut Microbiome and Cancer and CVD;
  • New biomarkers for the early detection of cancer and CVD.

This Special Issue on “Editorial Board Members’ Collection Series: “Pathology of Cancer and Cardiovascular Disease”” welcomes original research articles and reviews in this field.

Dr. Mridula Chopra
Dr. Helen L. Fillmore
Dr. Maurizio Forte
Guest Editors

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Keywords

  • cancer
  • cardiovascular disease
  • biomarkers
  • gut microbiome
  • inflammation
  • health policy
  • diet and lifestyle

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Published Papers (2 papers)

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Research

12 pages, 707 KiB  
Article
Fresh Tomato (Lycopersicon esculentum Mill.) in the Diet Improves the Features of the Metabolic Syndrome: A Randomized Study in Postmenopausal Women
by Chein-Yin Chen and Yi-Wen Chien
Biology 2024, 13(8), 588; https://doi.org/10.3390/biology13080588 - 3 Aug 2024
Viewed by 1423
Abstract
(1) Background: According to the 2005~2008 Nutrition and Health Survey in Taiwan (NAHSIT), more than half of Taiwanese women (57.3%) had metabolic syndrome during menopause. Metabolic syndrome is a set of risk factors for cardiovascular disease (CVD) that increase the risk of cardiovascular [...] Read more.
(1) Background: According to the 2005~2008 Nutrition and Health Survey in Taiwan (NAHSIT), more than half of Taiwanese women (57.3%) had metabolic syndrome during menopause. Metabolic syndrome is a set of risk factors for cardiovascular disease (CVD) that increase the risk of cardiovascular disease, diabetes, and mortality. Epidemiological studies suggest that the consumption of tomato-based foods might reduce the risk factors for CVD. The aim of this study is to examine the effects of tomato consumption on lowering the metabolic syndrome risk factors among overweight postmenopausal women. (2) Methods: We conducted a randomized controlled trial using 8-week open-label dietary intervention. Overweight postmenopausal women aged 45–70 years old were recruited from Taipei Medical University in October 2013. They were randomly assigned into two groups (a control diet vs. a tomato diet). Blood samples were collected at the baseline and at the 4th and 8th weeks. The lipid profile, blood sugar, and antioxidant biomarkers, i.e., the ferric-reducing ability of plasma (FRAP) and serum carotenoids, were analyzed. Blood pressure, body weight, and body fat were also measured every week. (3) Results: After the 8-week dietary intervention, body weight, body mass index, waist circumference, and hip circumference were significantly lower in both groups (p < 0.05). Body fat mass, body fat percentage, waist circumference, and hip circumference were significantly lower in the tomato diet group than in the control diet group. The tomato diet group had significantly lower serum total cholesterol, triglyceride, systolic blood pressure and blood sugar, and higher high-density lipoprotein cholesterol than the control diet group. The antioxidant biomarkers, FRAP, beta-carotenoids, and lycopene were significantly higher in the tomato diet group than in the control diet group. (4) Conclusions: Fresh tomato consumption can increase antioxidant biomarkers to reduce risks of metabolic syndrome in postmenopausal women. Full article
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22 pages, 3384 KiB  
Article
Discovery of TBX20 as a Novel Gene Underlying Atrial Fibrillation
by Ning Li, Yan-Jie Li, Xiao-Juan Guo, Shao-Hui Wu, Wei-Feng Jiang, Dao-Liang Zhang, Kun-Wei Wang, Li Li, Yu-Min Sun, Ying-Jia Xu, Yi-Qing Yang and Xing-Biao Qiu
Biology 2023, 12(9), 1186; https://doi.org/10.3390/biology12091186 - 30 Aug 2023
Cited by 2 | Viewed by 1797
Abstract
Atrial fibrillation (AF), the most prevalent type of sustained cardiac dysrhythmia globally, confers strikingly enhanced risks for cognitive dysfunction, stroke, chronic cardiac failure, and sudden cardiovascular demise. Aggregating studies underscore the crucial roles of inherited determinants in the occurrence and perpetuation of AF. [...] Read more.
Atrial fibrillation (AF), the most prevalent type of sustained cardiac dysrhythmia globally, confers strikingly enhanced risks for cognitive dysfunction, stroke, chronic cardiac failure, and sudden cardiovascular demise. Aggregating studies underscore the crucial roles of inherited determinants in the occurrence and perpetuation of AF. However, due to conspicuous genetic heterogeneity, the inherited defects accounting for AF remain largely indefinite. Here, via whole-genome genotyping with genetic markers and a linkage assay in a family suffering from AF, a new AF-causative locus was located at human chromosome 7p14.2-p14.3, a ~4.89 cM (~4.43-Mb) interval between the markers D7S526 and D7S2250. An exome-wide sequencing assay unveiled that, at the defined locus, the mutation in the TBX20 gene, NM_001077653.2: c.695A>G; p.(His232Arg), was solely co-segregated with AF in the family. Additionally, a Sanger sequencing assay of TBX20 in another family suffering from AF uncovered a novel mutation, NM_001077653.2: c.862G>C; p.(Asp288His). Neither of the two mutations were observed in 600 unrelated control individuals. Functional investigations demonstrated that the two mutations both significantly reduced the transactivation of the target gene KCNH2 (a well-established AF-causing gene) and the ability to bind the promoter of KCNH2, while they had no effect on the nuclear distribution of TBX20. Conclusively, these findings reveal a new AF-causative locus at human chromosome 7p14.2-p14.3 and strongly indicate TBX20 as a novel AF-predisposing gene, shedding light on the mechanism underlying AF and suggesting clinical significance for the allele-specific treatment of AF patients. Full article
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