Neuroprotective Strategies in Preclinical Animal Models of Neurological Disorders
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".
Deadline for manuscript submissions: 30 December 2026
Special Issue Editor
Interests: neuroprotective mechanisms; neurodegeneration; neurodegenerative disorders; molecular biology; neuronal death; synaptic dysfuncion; in vivo and in vitro experimental models
Special Issue Information
Dear Colleagues,
understanding neuroprotective mechanisms is crucial for tackling the onset and progression of neurological disorders, including a broad spectrum of neurodegenerative and neurodevelopmental diseases. Preclinical animal models are essential tools for dissecting the molecular and cellular events underlying neuronal injury, synaptic dysfunction, neuroinflammation, glial alterations, and retinal–brain degeneration. These models provide unique platforms for investigating intracellular signaling pathways, microglia–neuron interactions, oxidative stress responses, and the contribution of protein post-translational modifications to neuronal vulnerability. They also support the development and validation of innovative therapeutic strategies, including peptide-based inhibitors, neurotrophins, antioxidants, gene-targeted interventions, and small-molecule modulators aimed at preventing neuronal loss and restoring synaptic function. We are pleased to invite you to submit your latest findings to this Special Issue.
This Special Issue aims to highlight advances in experimental neuroprotection using preclinical animal models, with a focus on molecular and cellular pathways that promote neuronal resilience and early therapeutic intervention. The topic aligns with the journal’s mission to publish biologically relevant studies that contribute to understanding human nervous system health and disease. This collection seeks to bridge mechanistic discoveries with translational potential, fostering interdisciplinary perspectives for the prevention and treatment of neurological disorders.
In this Special Issue, original research articles and review papers are welcome. Potential topics include, but are not limited to, the following:
- Neuroprotective mechanisms in neurodegeneration and neurodevelopmental disorders;
- Synaptic protection and restoration of neuronal connectivity;
- Microglia–neuron interaction and glial-mediated neuroprotection;
- Intracellular signaling pathways and protein post-translational modifications;
- Antioxidants, neurotrophins, peptide-based or gene-targeted therapies;
- Biomarkers of neuroprotection and early therapeutic intervention;
- Retina–brain axis and visual system models in neuroprotection.
We look forward to receiving your contributions.
Dr. Lucia Buccarello
Guest Editor
Manuscript Submission Information
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Keywords
- neuroprotective strategies
- intracellular signaling pathways
- synaptic dysfunction
- oxidative stress: neuronal/cell death
- preclinical animal models
- neurodegeneration
- microglia–neuron interaction
- neurotrophin signaling
- natural compounds
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