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Biology
Special Issues
Feature Papers in Immunology
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Feature Papers in Immunology

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 30 December 2026 | Viewed by 819

Special Issue Editors

Prof. Dr. Natalia Osna

E-Mail Website
Guest Editor
Department of Internal Medicine, University of Nebraska Medical Center, Veteran Affairs Medical Center, 4101 Woolworth Ave, R151, Omaha, NE 68105-8080, USA
Interests: hepatitis C, B, HIV, and other viral hepatitis; alcohol-associated liver disease; innate immunity; antigen presentation; proteasome; protein posttranslational modifications; animal models for a hepatitis study; long-acting drugs
Special Issues, Collections and Topics in MDPI journals
Dr. Anup Singh Pathania

E-Mail Website
Guest Editor
1. Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
2. The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
Interests: non-coding RNAs; cancer; cancer immunology; autophagy; apoptosis; cancer drug discovery; pediatric tumors

Special Issue Information

Dear Colleagues,

The field of immunology continues to evolve rapidly, driven by advances in molecular biology, high-resolution imaging, and multi-omics technologies. This Special Issue of the Immunology Section brings together a collection of featured papers that highlight recent progress in both fundamental and translational immunology. The selected studies will explore diverse aspects of immune regulation, host–pathogen interactions, and immune responses in disease contexts ranging from infection and cancer to autoimmunity and metabolic disorders. Emphasis will be placed on innovative mechanisms of immune modulation and novel therapeutic approaches targeting immune pathways. Several contributions will also address how immune cell metabolism, signaling networks, and the microenvironment shape immune functions. Collectively, these featured papers underscore the integrative nature of modern immunology and its pivotal role in improving human health. By presenting cutting-edge discoveries and critical reviews, this Special Issue aims to foster cross-disciplinary dialogue and stimulate future research directions.

Prof. Dr. Natalia Osna
Dr. Anup Singh Pathania
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immune regulation and signaling networks
  • host–pathogen interactions
  • innate and adaptive immune responses
  • immunometabolism and metabolic control of immunity
  • tumor immunology and immune evasion
  • autoimmunity and inflammatory diseases
  • immune modulation and therapeutic targeting
  • microenvironmental regulation of immune function
  • molecular and cellular mechanisms of immunity
  • multi-omics and systems immunology approaches

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Published Papers (1 paper)

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Research

27 pages, 3773 KB  
Article
Multiepitope-Based Peptide Vaccine Against A35R Glycoprotein and E8L Membrane Protein of Monkeypox Virus Using an Immunoinformatics Approach
by Laaiba Attique, Syed Babar Jamal, Tayyaba Gulistan, Adnan Haider, Deeba Amraiz, Sumra Wajid Abbasi, Sajjad Ahmad and Mohammad Abdullah Aljasir
Biology 2026, 15(7), 524; https://doi.org/10.3390/biology15070524 - 25 Mar 2026
Viewed by 539
Abstract
Monkeypox virus, a zoonotic DNA virus belonging to the Orthopoxvirus genus, has emerged as a global health issue because of its fast spread to 104 nations over six continents. In the current study, an immunoinformatics pipeline was used to design a multiepitope-based prophylactic [...] Read more.
Monkeypox virus, a zoonotic DNA virus belonging to the Orthopoxvirus genus, has emerged as a global health issue because of its fast spread to 104 nations over six continents. In the current study, an immunoinformatics pipeline was used to design a multiepitope-based prophylactic vaccine targeting the A35R glycoprotein and E8L membrane proteins of the monkeypox virus. Selected target proteins were surface-exposed, non-homologous to the human proteome, and essential for viral pathogenesis. B-cell and T-cell (MHC-I and MHC-II) epitopes with high antigenicity (>0.5), non-allergenicity, non-toxicity, and highly soluble in water with strong affinity towards innate and adaptive receptors, were prioritized. Shortlisted epitopes were combined to design the final vaccine utilizing an adjuvant (50S ribosomal L7/L12) and appropriate linkers for improved immunogenicity. Population coverage analysis showed wide HLA representation with 83.57% (MHC-I) and 88.8% (MHC-II) global coverage, including 89.6% for West Africa and 87.3% for Central Africa. Docking analysis of the vaccine construct with the TLR-4 receptor revealed stable interactions (−695.6 kcal/mol). Molecular dynamics simulations and binding free energies further confirmed structural stability. Immune simulations predicted strong activation of both humoral and cellular immune responses. These results indicate that the designed multiepitope vaccine construct is a viable option for additional experimental validation against the monkeypox virus. Full article
(This article belongs to the Special Issue Feature Papers in Immunology)
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