Perspective of Signal Transduction in Cancer and Inflammation
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".
Deadline for manuscript submissions: 30 December 2026 | Viewed by 165
Special Issue Editors
Interests: immuno-oncology; tumor microenvironment; signal transduction; cytokines; JAK/STAT; signal transduction immune checkpoints; T-cell exhaustion
Special Issue Information
Dear Colleagues,
Signaling pathways are fundamental regulatory networks that coordinate cellular communication and function in immune and cancer cells. By shaping the tumor microenvironment (TME), these programs can determine immunotherapy response or resistance. This Special Issue in Biology will highlight mechanistic and translational advances that define actionable signaling circuits across tumor, immune, and stromal compartments. We welcome original research and reviews on cytokine-driven pathways (e.g., JAK/STAT), NF-κB and interferon signaling, innate sensing modules, inflammasome activation, and pathway crosstalk controlling antigen presentation, myeloid reprogramming, and immune exclusion. We also encourage submissions on checkpoint pathway wiring that regulates exhaustion, stem-like T-cell states, and reinvigoration, as well as crosstalk among TGF-β/Wnt/Notch/Hippo pathways driving immune exclusion or infiltration. Studies combining functional validation with modern approaches, are encouraged. Together, these contributions will provide a timely reference for researchers developing next-generation immuno-oncology strategies grounded in signaling biology.
We look forward to your submissions.
Prof. Dr. Sonia León-Cabrera
Dr. Araceli Perez-Lopez
Guest Editors
Manuscript Submission Information
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Keywords
- immuno-oncology
- tumor microenvironment
- signal transduction
- cytokines
- JAK/STAT
- NF-κB
- inflammasome
- T-cell dysfunction
- myeloid reprogramming
- biomarkers
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