Recent Advances in Understanding Systemic Lupus Erythematosus Pathogenesis
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".
Deadline for manuscript submissions: 15 December 2025 | Viewed by 59
Special Issue Editor
Special Issue Information
Dear Colleagues,
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease marked by a wide spectrum of clinical manifestations and complex immunopathogenic mechanisms. Despite significant progress in elucidating its underlying biology, many aspects of SLE pathogenesis remain poorly understood, hindering the development of effective and targeted therapies.
We are pleased to invite you to submit original research articles, short communications, and review papers that will advance our collective understanding of SLE and pave the way towards more precise diagnostic and therapeutic strategies.
This Special Issue aims to bring together cutting-edge research and comprehensive reviews that address the latest developments in the field. We welcome contributions that explore the cellular and molecular mechanisms driving immune dysregulation in SLE, including the roles of B and T lymphocytes, type I interferon pathways, autoantibody production, and the influence of genetic, epigenetic, hormonal, and environmental factors. Studies highlighting novel biomarkers, therapeutic targets, and innovative methodologies, such as single-cell omics, advanced imaging, and systems biology, are particularly encouraged.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Immune dysregulation in SLE;
- Genetic and epigenetic aspects of SLE;
- Role of hormonal and environmental factors in SLE;
- Novel biomarkers, therapeutic targets, and innovative methodologies in SLE;
- Molecular mechanisms of target organ damage in SLE.
I look forward to receiving your contributions.
Dr. Rohit Upadhyay
Guest Editor
Manuscript Submission Information
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Keywords
- systemic lupus erythematosus (SLE)
- autoimmunity
- immune dysregulation
- B and T cell biology
- interferon signaling
- autoantibodies
- epigenetics
- biomarkers
- therapeutic targets
- systems immunology
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