Ammonium aminomethylphosphonate monohydrate was synthesized via aqueous neutralization of aminomethylphosphonic acid with ammonium carbonate. The compound was fully characterized by FT-IR and NMR spectroscopy, as well as single-crystal X-ray diffract...
Methyl propiolate is known to react with a variety of sulfur compounds to give variable mixtures of the (Z,Z), (E,Z) and (E,E) isomers of dimethyl 3,3′-thiodiacrylate. From the reaction of methyl propiolate and thiourea in methanol, we have obt...
The title compounds have been known for many years and have been widely used to generate alkoxycarbonylnitrenes by α-elimination as well as for other synthetic transformations. Although they have previously been characterised by spectroscopic m...
In this work, we carried out a double C–H thiocyanation of 7-methoxy-1H-indole to afford the novel 7-methoxy-3,4-dithiocyanato-1H-indole in good yield. The structure of the target product was confirmed by 1H and 13C NMR spectroscopy, FT-IR spec...
A two-stage synthesis of the novel compound 1-(1-methyl-5-thiocyanato-1H-pyrrol-2-yl)-3-nitro-1H-1,2,4-triazole utilizing electrochemistry as an environmentally benign tool is reported. The structure of the target molecule was confirmed by 1H and 13C...
A novel cyclic chalcone analogue, (E)-6-((4-(3,4-dichlorophenyl)-1-oxo-3,4-dihydronaphthalen-2(1H)-ylidene)methyl)-3-methylbenzo[d]oxazol-2(3H)-one (3), was synthesized by acid-catalyzed condensation of 4-(3,4-dichlorophenyl)-1-tetralone (1) with 3-m...
Overexpression of protein phosphatase 5 (PP5) has been implicated in tumor cell growth, making PP5 an attractive target for the development of small-molecule anticancer therapeutics. Building on previous success in achieving selectivity within the PP...
A new hybrid heterocyclic compound, 2-[(4-amino-4H-1,2,4-triazol-3-yl)sulfanyl]-1-[4-(4-chlorophenyl)piperazin-1-yl]ethan-1-one (3), was synthesized by the reaction of 4-amino-4H-1,2,4-triazole-3-thione with 2-chloro-1-[4-(4-chlorophenyl)piperazin-1-...
A novel Schiff base, 2-((1-(naphthalen-2-yl)ethylidene)amino)aniline, was successfully synthesized in the present work. The target compound was systematically characterized using 1H nuclear magnetic resonance (NMR) spectroscopy, 13C NMR spectroscopy...
With a view to introducing oxygen functionality at the 2-position, a range of N-methyl pyrrole derivatives functionalised with various ortho-directing groups at the 3-position have been prepared and fully characterised using spectroscopic methods.
The development of efficient cationic amphiphiles remains an important area in the design of nonviral systems for nucleic acid delivery. In this study, we report the synthesis of three lysine-containing lipid-like amphiphiles incorporating pyrrole, f...
A new hybrid molecule, combining the pharmacologically relevant scaffolds of valproic acid and trimetazidine, is reported. The target compound was synthesized via a rapid mechanochemical approach using a planetary ball mill, enabling the efficient co...
A new fused triazinobenzimidazole derivative, 4-(3,5-dimethoxyphenyl)-3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazin-2-amine, was synthesized via one-step cyclocondensation reaction. The target compound was obtained in good yield and characterized...
This research aimed to develop a new semisynthetic piperine compound derived from black pepper (Piper nigrum, Piperaceae), commonly known as “King of Spices”. Piperine was isolated from the ethanolic extract of Piper nigrum by the Soxhlet...
The reaction of Cd(NO3)2·4H2O with the fluorescent ditopic N-donor ligand 2,5-bis[(pyridin-3-yl)ethynyl]thiophene (L) afforded the new coordination polymer {[Cd(L)(H2O)2(NO3)2]∙1.25H2O}n (1). Single-crystal X-ray diffraction analysis rev...
A new carboxylic acid-functionalized 2,2′-bipyridine derivative, (2E,2′E)-3,3′-(2,2′-bipyridine-6,6′-diyl)diacrylic acid (3), was synthesized in two steps from 6,6′-dibromo-2,2′-bipyridine. A palladium-cataly...
Two previously undescribed sulfobetaine zwitterions bearing benzyl ester and amide functionalities were synthesized through a concise three-step sequence starting from benzyl alcohol and either succinic or glutaric anhydride. The route comprised este...
This work reports the synthesis of a previously uncharacterized N1-(1-(naphthalen-2-yl)ethyl)benzene-1,2-diamine derivative, a member of the aromatic diamine Schiff base family that has not been documented in the existing literature. The full set of...
This study reports the synthesis of two new compounds, methyl 3-(3-(benzo[d][1,3]dioxol-5-ylmethyl)ureido)benzoate and 3-(3-(benzo[d][1,3]dioxol-5-ylmethyl)ureido)benzoic acid, prepared via the addition of an amine to an isocyanate to generate the co...
The study focuses on the synthesis and structural characterization of 2,3-diphenyldibenzo[b,f]imidazo[1,2-d][1,4]oxazepine-6,7-dicarbonitrile. The target compound was obtained via a nucleophilic aromatic substitution reaction between 2-(2-hydroxyphen...
The crystal structure of the benzophenanthridine alkaloid dihydrochelerythrine (1,2-dimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine), C21H19NO4, was determined by single-crystal X-ray diffraction analysis. The alkaloid was isolated fro...
Herein, the previously unreported (E)-1-(2-hydroxy-4-methoxyphenyl)-3-(5-methylfuran-2-yl)prop-2-en-1-one 3 was synthesized by Claisen–Schmidt condensation of 1-(2-hydroxy-4-methoxyphenyl)ethan-1-one 1 and 5-methylfuran-2-carbaldehyde 2 using p...
The crystal structures of two isomeric urea derivatives—1,1-dimethyl-3-(quinolin-2-yl)urea (1) and 3-(isoquinolin-1-yl)-1,1-dimethylurea (2)—have been investigated by single-crystal X-ray diffraction. These compounds differ in the relativ...
Reduction of [Tc(CO)5Br] with sodium amalgam, sodium naphthalenide, or potassium graphite in THF and subsequent addition of bis(triphenylphosphine)iminium chloride, (PPN)Cl, gave mixtures of the orange-yellow Tc(0) compound (PPN)[Tc(CO)9Cl], (PPN)[1]...
Under the application of a semi-synthesis strategy, an acylhydrazone derivative from strictic acid (SA), a natural neo-clerodane diterpenoid with a unique 5,10-seco skeleton isolated from Schnabelia terniflora, has been synthesized via a two-step syn...
The indole core is a structural component of a huge number of biologically active natural and synthesized compounds and pharmaceuticals, and their efficient synthesis is an important challenge. Fluorinated indoles have attracted considerable attentio...
Macrocyclic tetraimidazolium salts 2 and 3 containing propylene and m-phenylene linkers were synthesized from diimidazole derivative 1 and 1,3-diiodopropane. The molecular structure of 3 was determined by single-crystal X-ray diffraction analysis, re...
We report the synthesis of a modified benzothiazole sulfide. This compound contains a heterocyclic core, a Boc-protected hydroxylamine, and an appended alkyne. This benzothiazole was accessed through three total steps, including an amidation reaction...
The monoterpene-derived 1,4-oxazepan-3-one, (5aS,8R,9aR)-5,5,8-trimethyloctahydrobenzo[f][1,4]oxazepin-3(2H)-one, was synthesized from the corresponding (−)-isopulegol-based chloroacetamide by intramolecular cyclization in acetonitrile. The pro...
This study reports the synthesis and characterization of a dinuclear zinc(II) complex, [Zn2(L1)2(L2)]·DMF·Et3N (C45H54F2N10O5S2Zn2), constructed from a fluoro-substituted thiosemicarbazone Schiff base ligand (2-(3-fluoro-5-hydroxybenzyl...
The previously unreported seven-membered-ring benzanilide derivative, 2-([1,1′-biphenyl]-4-yl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-1-one (1), was synthesized and structurally characterized by spectroscopic methods and single-crystal X-ray diff...
Reaction of 2-(3,5-dichloro-4H-1,2,6-thiadiazin-4-ylidene)malononitrile with sodium 2-aminophenolate (1.5 equiv.) in anhydrous THF at ca. 0–20 °C afforded the known 4-chlorobenzo[5,6][1,4]oxazino[2,3-c][1,2,6]thiadiazine in 76% yield. In co...
This work presents the synthesis and structural characterization of a previously unknown palladium(II) complex with (2E)-2-[1-(4-aminophenyl)ethylidene]hydrazine-1-carbothioamide, which in the solid state forms a highly symmetric tetrametallic metall...
1-[(4S)-4-benzyl-1,3-oxazolidin-2-one-3-yl]propyltriphenylphosphonium tetrafluoroborate was synthesized in a two-step procedure starting from (4S)-4-benzyl-3-propionyl-1,3-oxazolidin-2-one. In the first step, (4S)-4-benzyl-3-propionyl-1,3-oxazolidin-...
This work describes the synthesis of 4-methyl-N-(2-methylbenzyl)-N′-(2-methylbenzylidene)benzenesulfonohydrazide. Full characterization of the target compound is achieved through melting point measurement, 1H NMR, 13C NMR spectroscopy and mass...
The design of solar cells with a bulk heterojunction is one of the most promising areas in renewable energy sources. Acceptor dopants with suitable physical characteristics are desirable components for ternary organic solar cells with cascade charge...
Imidazo [2,1-b][1,3]thiazines and their fused analogues are an important class of nitrogen- and sulfur-containing heterocycles that exhibit a wide range of biological activities. Herein, a straightforward synthetic protocol for 2,3-dihydro-5H-imidazo...
Herein, we report the rapid mechanochemical synthesis of a novel hybrid amide, (±)-2-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylacetamide. The target compound was obtained via direct acylation of 1,4-benzodioxan-6-amine with (&plus...
The target (1E,4E)-1,5-bis(2,4-dichlorophenyl)penta-1,4-dien-3-one oxime 4 was prepared in good yield, as a key aza-precursor for the Nazarov cyclization, through a two-step sequence in this study. Initially, the starting divinyl ketone 1a was obtain...
Compounds containing electron-withdrawing dicyanopyrazine and 1,2,5-chalcogenadiazole fragments are promising for the design of magnetic and optoelectronic materials. In this paper, bis([1,2,5]thiadiazolo)[3,4-f:3′,4′-h]quinoxaline-8,9-di...
Gymnaconitum gymnandrum, a Tibetan medicinal herb, is distributed across high-altitude regions of China. Despite its high toxicity, it exhibits analgesic, anti-inflammatory, antitumor, and other pharmacological activities. It is used topically for sk...
A novel spiro[indoline-3,2′-thiazolidine]-2,4′-dione derivative incorporating 3-chloro-4-fluorophenyl and 6-methoxypyridin-3-yl fragments was synthesized and characterized. The synthetic route involved a two-step procedure, including the...
Levofloxacin is an antibiotic belonging to the fluoroquinolone family. N-Demethyllevofloxacin, a metabolite and an impurity of levofloxacin, features a secondary amine that is susceptible to N-nitrosation, raising concerns about the formation of a po...
We have recently demonstrated that the pendant tert-butyldiphenylsilyl (TBDPS) groups in the short oligonucleotides TBDPS-5′-CG-3′-3′-GC-5′-TBDPS and TBDPS-5′-CGG-3′-3′-GGC-5′-TBDPS promoted the formati...
The reaction of 8-hydroxyquinoline and (2R,7R,11S,16S)-1,8,10,17-tetraazapentacyclo [8.8.1.1.8,170.2,70.11,16]icosane under Mannich-type conditions afforded a new quinoline-functionalized diazabicyclic derivative in 27% yield. The structure of the pr...
In the original publication [...]
1,2-Dichloroethane was found to stabilize the lattice of chloride anions associated with the protonated porphyrin of formula [C44H32N4]Cl2·4C2H4Cl2. The synthesis and X-ray characterization of this compound are reported and compared with analo...
A new benzimidazole–6β-acetoxyvouacapane (4aS,5R,6aS,7R,11aS,11bR)-9-(1-benzyl-1H-benzo[d]imidazol-2-yl)-4,4,7,11b-tetramethyl-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-5-yl acetate was synthesized through the semisy...
4,8,12-Trioxaphosphangulene is a bowl-shaped phosphorus-containing π-conjugated molecule whose molecular geometry is highly sensitive to the substituent attached to the phosphorus atom. Herein, we report the synthesis of a new tungsten pentacarbon...
Tertiary (2H-azirin-2-yl)ammonium salts were prepared from methyl 2-halo-3-aryl-2H-azirine-2-carboxylates and 1,4-diazabicyclo[2.2.2]octane in very good to excellent yields. Both iodide and bromide salts are stable enough in crystalline form to be st...
