2026 June - 17 articles
Lactose is widely used as a pharmaceutical excipient, yet little is known about how its physicochemical behavior may be influenced by pretreatment history and weak environmental magnetic conditions. In this pilot study, we investigated oxidation&ndas...
Pulse wave propagation through blood vessels is affected by many biophysical parameters that change with aging. The aim of this study was to investigate both theoretically and experimentally how the pulse wave velocity changes in the vertical positio...
It has recently been shown that by sequential vibrational processing (named ‘crossing’) of two closely located vials with the initial substance in one of them and water or lactose in the other, it is possible to obtain novel products, or...
This study aimed to evaluate the surface changes depicted on Reciproc and Reciproc Blue R25 files after their immersion in different irrigants at different temperatures compared to the non-immersed controls, utilizing Atomic Force Microscopy (AFM). T...
Emotion recognition (ER) in human–computer interaction (HCI) holds immense potential for real-world applications, but traditional approaches based on electroencephalography (EEG) face challenges due to the complexity and impracticality of colle...
The Senegal tree (Sengalia senegal) is the primary plant source of Gum Arabic (GA), a natural secretion rich in soluble fiber and bioactive polysaccharides. It has longstanding uses in traditional medicine, nutrition, and pharmaceuticals. The present...
Beta Secretase (BACE1) is a well-validated target for Alzheimer’s therapies, but there has been attrition in drug development. Herein, we leveraged machine learning (ML), virtual screening and molecular dynamics (MD) to identify novel compounds...
Telmisartan (TEL) is a non-peptide, orally administered antihypertensive agent primarily known as angiotensin II type 1 (AT1) blocker. In this review, we provide a detailed overview of how TEL modulates voltage-gated Na+ current (INa) and affects act...
Electroencephalographic (EEG) signals provide macroscopic observables of complex neural dynamics. We introduce a horizon-inspired framework in which measured EEG signals are modeled as projections of a complex wave-like representation constrained by...
A Fixed-dose combination (FDC) therapy of ezetimibe (EZT) and atorvastatin (ATV) is increasingly prescribed for high-risk hyperlipidemic patients with cardiovascular disease. However, the pharmaceutical production of FDC EZT/ATV tablets often results...
Deep brain stimulation (DBS) with implantable pulse generators (IPGs) is widely used in the treatment of movement disorders. Rechargeable IPGs (RC-IPGs) were developed to extend device longevity and address the limitations of battery life in non-rech...
Alzheimer’s disease (AD) is the most common form of dementia, characterized by the progressive accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles of tau protein in and around neurons. However, these markers appear rela...
Herein, we report a simple procedure regarding the photodynamic therapy (PDT) treatment as a minimally invasive modality for treating superficial bladder cancer that utilizes a photosensitizer, light, and oxygen to generate cytotoxic reactive oxygen...
Climate change significantly affects human physiology and contributes to increased morbidity and mortality, with heat stress representing one of the most severe consequences of thermal imbalance. The aim of this study was to analyze morphological cha...
Chagas disease remains a major neglected parasitic illness in Latin America and other endemic regions, and benznidazole (BZN) is still the primary trypanosomacidal drug despite its incompletely understood mechanism of action. This work provides a det...
Cynodon dactylon (Bermuda grass) is a perennial medicinal grass widely distributed across tropical and subtropical regions and known for its antioxidant and anti-inflammatory properties. The present study aimed to identify bioactive metabolites from...
Coaggregation by bridging bacteria such as Fusobacterium nucleatum is considered a key element in dental biofilm development and maturation. Previous studies showed that sublethal exposure to blue light caused damage to cell membrane integrity. The a...
