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Stats, Volume 6, Issue 1

March 2023 - 29 articles

Cover Story: To accelerate the results of a clinical trial, investigators often rely on intermediate or “surrogate” endpoints that can be obtained earlier than the ultimate or “true” endpoint of interest.  For example, tumor growth may be observed well in advance of death in a cancer setting. There are settings in which the proposed surrogate endpoint is positively correlated with the true endpoint, but the treatment has opposite effects on the surrogate and true endpoints, a phenomenon labeled as “surrogate paradox”. Covariate information may be useful in predicting an individual’s risk of surrogate paradox. In this work, we extend methods to estimate the risk of this paradox as a function of different baseline covariates (for example, males versus females). View this paper
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Articles (29)

  • Article
  • Open Access
1 Citations
2,394 Views
14 Pages

Efficient Two-Stage Analysis for Complex Trait Association with Arbitrary Depth Sequencing Data

  • Zheng Xu,
  • Song Yan,
  • Shuai Yuan,
  • Cong Wu,
  • Sixia Chen,
  • Zifang Guo and
  • Yun Li

19 March 2023

Sequencing-based genetic association analysis is typically performed by first generating genotype calls from sequence data and then performing association tests on the called genotypes. Standard approaches require accurate genotype calling (GC), whic...

  • Article
  • Open Access
2,597 Views
18 Pages

18 March 2023

A phylogenetic regression model that incorporates the network structure allowing the reticulation event to study trait evolution is proposed. The parameter estimation is achieved through the maximum likelihood approach, where an algorithm is develope...

  • Article
  • Open Access
2,292 Views
12 Pages

Consecutive-k1 and k2-out-of-n: F Structures with a Single Change Point

  • Ioannis S. Triantafyllou and
  • Miltiadis Chalikias

16 March 2023

In the present paper, we establish a new consecutive-type reliability model with a single change point. The proposed structure has two common failure criteria and consists of two different types of components. The general framework for constructing t...

  • Brief Report
  • Open Access
2,535 Views
7 Pages

15 March 2023

Using geometric considerations, we provided a clear derivation of the integral representation for the error function, known as the Craig formula. We calculated the corresponding power series expansion and proved the convergence. The same geometric me...

  • Article
  • Open Access
12 Citations
4,226 Views
20 Pages

3 March 2023

The COVID-19 outbreak has rapidly affected global economies and the parties involved. There was a need to ensure the sustainability of corporate finance and avoid bankruptcy. The reactions of individuals were not routine, but covered a wide range of...

  • Article
  • Open Access
2,051 Views
16 Pages

22 February 2023

The purpose of this note is to provide a description of the weak convergence of the random resample size bootstrap empirical process. The principal results are used to estimate the sample rank correlation coefficients using Spearman’s and Kenda...

  • Brief Report
  • Open Access
7 Citations
3,581 Views
11 Pages

19 February 2023

Researchers interested in the assessment of substance use trajectories, and predictors of change, have several data analysis options. These include, among others, generalized estimating equations and latent growth curve modeling. One difficulty in th...

  • Communication
  • Open Access
4 Citations
3,220 Views
9 Pages

17 February 2023

This work presents a brief review on the modern approaches to data modeling by the methods developed in the quantum physics during the last one hundred years. Quantum computers and computations have already been widely investigated theoretically and...

  • Article
  • Open Access
6 Citations
2,519 Views
23 Pages

Incorporating Covariates into Measures of Surrogate Paradox Risk

  • Fatema Shafie Khorassani,
  • Jeremy M. G. Taylor,
  • Niko Kaciroti and
  • Michael R. Elliott

17 February 2023

Clinical trials often collect intermediate or surrogate endpoints other than their true endpoint of interest. It is important that the treatment effect on the surrogate endpoint accurately predicts the treatment effect on the true endpoint. There are...

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Stats - ISSN 2571-905X