Tomography, Volume 8, Issue 6
2022 December - 29 articles
Cover Story: The objective of this prospective pilot study was to determine if FDG-PET/MRI alters clinical response assessments among rectal cancer patients undergoing total neoadjuvant therapy (TNT) followed by nonoperative management (NOM), relative to MRI alone. In all, 7 of 14 subjects completed post-TNT restaging FDG-PET/MRIs; 5 of 7 subjects had evidence of residual disease and underwent resection; and 2 of 7 subjects had initial clinical complete response (cCR) with no evidence of disease after 12 months of NOM. FDG-PET/MRI assessments of cCR status at post-TNT restaging were 100% accurate, compared with 71% for MRI alone, as FDG-PET detected residual tumor in 2 more subjects. FDG-PET provided added value in 82% of restaging/surveillance scans. Our preliminary data indicate that FDG-PET/MRI can detect more residual disease after TNT than MRI alone. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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