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Tomography
Special Issues
Quantitative Imaging in Oncology
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Quantitative Imaging in Oncology

A special issue of Tomography (ISSN 2379-139X).

Deadline for manuscript submissions: closed (30 December 2022) | Viewed by 14965

Special Issue Editor

Dr. Wonmo Sung

E-Mail Website
Guest Editor
Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
Interests: radiology; radiation oncology; medical physics; tumor

Special Issue Information

Dear Colleagues, 

The field of quantitative imaging analysis in oncology is rapidly evolving. Quantitative imaging in oncology has reached a critical mass of investigative capacity, ranging from molecular imaging to CT/MR-based imaging to image-guided radiation therapy. Imaging ability to diagnose and evaluate therapy response and forecast symptom development in cancer has advanced significantly. Moreover, advanced machine learning techniques, such as neural networks, are transforming the practice of quantitative imaging in oncology. Thus, this Special Issue is looking for papers, including the development and implementation of quantitative imaging methods, imaging protocols, software, and machine learning solutions for cancer patients.

Dr. Wonmo Sung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Tomography is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • radiology
  • radiation therapy
  • quantitative imaging
  • tumor

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Published Papers (6 papers)

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Editorial

Jump to: Research

2 pages, 159 KiB  
Editorial
Quantitative Imaging in Oncology
by Wonmo Sung
Tomography 2022, 8(4), 1676-1677; https://doi.org/10.3390/tomography8040139 - 24 Jun 2022
Cited by 2 | Viewed by 1319
Abstract
The Special Issue of Tomography is a collection of articles focused on the quantitative imaging methods in clinical oncology [...] Full article
(This article belongs to the Special Issue Quantitative Imaging in Oncology)

Research

Jump to: Editorial

15 pages, 5480 KiB  
Article
Textural Features of Mouse Glioma Models Measured by Dynamic Contrast-Enhanced MR Images with 3D Isotropic Resolution
by Karl Kiser, Jin Zhang and Sungheon Gene Kim
Tomography 2023, 9(2), 721-735; https://doi.org/10.3390/tomography9020058 - 24 Mar 2023
Viewed by 2167
Abstract
This paper investigates the effect of anisotropic resolution on the image textural features of pharmacokinetic (PK) parameters of a murine glioma model using dynamic contrast-enhanced (DCE) MR images acquired with an isotropic resolution at 7T with pre-contrast T1 mapping. The PK parameter maps [...] Read more.
This paper investigates the effect of anisotropic resolution on the image textural features of pharmacokinetic (PK) parameters of a murine glioma model using dynamic contrast-enhanced (DCE) MR images acquired with an isotropic resolution at 7T with pre-contrast T1 mapping. The PK parameter maps of whole tumors at isotropic resolution were generated using the two-compartment exchange model combined with the three-site-two-exchange model. The textural features of these isotropic images were compared with those of simulated, thick-slice, anisotropic images to assess the influence of anisotropic voxel resolution on the textural features of tumors. The isotropic images and parameter maps captured distributions of high pixel intensity that were absent in the corresponding anisotropic images with thick slices. A significant difference was observed in 33% of the histogram and textural features extracted from anisotropic images and parameter maps, compared to those extracted from corresponding isotropic images. Anisotropic images in different orthogonal orientations demonstrated 42.1% of the histogram and textural features to be significantly different from those of isotropic images. This study demonstrates that the anisotropy of voxel resolution needs to be carefully considered when comparing the textual features of tumor PK parameters and contrast-enhanced images. Full article
(This article belongs to the Special Issue Quantitative Imaging in Oncology)
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11 pages, 1115 KiB  
Article
Identification of the Benignity and Malignancy of BI-RADS 4 Breast Lesions Based on a Combined Quantitative Model of Dynamic Contrast-Enhanced MRI and Intravoxel Incoherent Motion
by Wenjuan Xu, Bingjie Zheng and Hailiang Li
Tomography 2022, 8(6), 2676-2686; https://doi.org/10.3390/tomography8060223 - 31 Oct 2022
Cited by 3 | Viewed by 2347
Abstract
The aim of this study was to explore whether intravoxel incoherent motion (IVIM) combined with a dynamic contrast–enhanced magnetic resonance imaging (DCE–MRI) quantitative model can improve the ability to distinguish between benign and malignant BI-RADS 4 breast lesions. We enrolled 100 patients who [...] Read more.
The aim of this study was to explore whether intravoxel incoherent motion (IVIM) combined with a dynamic contrast–enhanced magnetic resonance imaging (DCE–MRI) quantitative model can improve the ability to distinguish between benign and malignant BI-RADS 4 breast lesions. We enrolled 100 patients who underwent breast MRI at our institution and extracted the quantitative parameters of lesions with a post-processing workstation. Statistical differences in these parameters between benign and malignant BI-RADS 4 lesions were assessed using a two independent samples t-test or a Mann–Whitney U test. Binary logistic regression analysis was performed to establish five diagnostic models (model_ADC, model_IVIM, model_DCE, model_DCE+ADC, and model_DCE+IVIM). Receiver operating characteristic (ROC) curves, leave-one-out cross-validation, and the Delong test were used to assess and compare the diagnostic performance of these models. The model_DCE+IVIM showed the highest area under the curve (AUC) of 0.903 (95% confidence interval (CI): 0.828–0.953, sensitivity: 87.50%, specificity: 85.00%), which was significantly higher than that of model_ADC (p = 0.014) and model_IVIM (p = 0.033). The model_ADC had the lowest diagnostic performance (AUC = 0.768, 95%CI: 0.672–0.846) but was not significantly different from model_IVIM (p = 0.168). The united quantitative model with DCE–MRI and IVIM could improve the ability to evaluate the malignancy in BI-RADS 4 lesions, and unnecessary breast biopsies may be obviated. Full article
(This article belongs to the Special Issue Quantitative Imaging in Oncology)
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16 pages, 2381 KiB  
Article
Chemical Exchange Saturation Transfer for Lactate-Weighted Imaging at 3 T MRI: Comprehensive In Silico, In Vitro, In Situ, and In Vivo Evaluations
by Karl Ludger Radke, Daniel B. Abrar, Miriam Frenken, Lena Marie Wilms, Benedikt Kamp, Matthias Boschheidgen, Patrick Liebig, Alexandra Ljimani, Timm Joachim Filler, Gerald Antoch, Sven Nebelung, Hans-Jörg Wittsack and Anja Müller-Lutz
Tomography 2022, 8(3), 1277-1292; https://doi.org/10.3390/tomography8030106 - 7 May 2022
Cited by 6 | Viewed by 2350
Abstract
Based on in silico, in vitro, in situ, and in vivo evaluations, this study aims to establish and optimize the chemical exchange saturation transfer (CEST) imaging of lactate (Lactate-CEST—LATEST). To this end, we optimized LATEST sequences using Bloch–McConnell simulations for optimal detection of [...] Read more.
Based on in silico, in vitro, in situ, and in vivo evaluations, this study aims to establish and optimize the chemical exchange saturation transfer (CEST) imaging of lactate (Lactate-CEST—LATEST). To this end, we optimized LATEST sequences using Bloch–McConnell simulations for optimal detection of lactate with a clinical 3 T MRI scanner. The optimized sequences were used to image variable lactate concentrations in vitro (using phantom measurements), in situ (using nine human cadaveric lower leg specimens), and in vivo (using four healthy volunteers after exertional exercise) that were then statistically analyzed using the non-parametric Friedman test and Kendall Tau-b rank correlation. Within the simulated Bloch–McConnell equations framework, the magnetization transfer ratio asymmetry (MTRasym) value was quantified as 0.4% in the lactate-specific range of 0.5–1 ppm, both in vitro and in situ, and served as the imaging surrogate of the lactate level. In situ, significant differences (p < 0.001) and strong correlations (τ = 0.67) were observed between the MTRasym values and standardized intra-muscular lactate concentrations. In vivo, a temporary increase in the MTRasym values was detected after exertional exercise. In this bench-to-bedside comprehensive feasibility study, different lactate concentrations were detected using an optimized LATEST imaging protocol in vitro, in situ, and in vivo at 3 T, which prospectively paves the way towards non-invasive quantification and monitoring of lactate levels across a broad spectrum of diseases. Full article
(This article belongs to the Special Issue Quantitative Imaging in Oncology)
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9 pages, 2084 KiB  
Article
Quantitative Assessment of Airway Changes in Fibrotic Interstitial Lung Abnormality Patients by Chest CT According to Cumulative Cigarette Smoking
by Yuan Zhe Li, Gong Yong Jin, Kum Ju Chae and Young Min Han
Tomography 2022, 8(2), 1024-1032; https://doi.org/10.3390/tomography8020082 - 3 Apr 2022
Cited by 4 | Viewed by 2463
Abstract
Purpose: The aim of this study was to evaluate the role of Pi10 in patients with fibrotic interstitial lung abnormality (fibrotic ILA) in a chest CT, according to cumulative cigarette smoking. Methods: We retrospectively assessed 54 fibrotic ILA patients and 18 healthy non-smokers [...] Read more.
Purpose: The aim of this study was to evaluate the role of Pi10 in patients with fibrotic interstitial lung abnormality (fibrotic ILA) in a chest CT, according to cumulative cigarette smoking. Methods: We retrospectively assessed 54 fibrotic ILA patients and 18 healthy non-smokers (control) who underwent non-enhanced CT and pulmonary function tests. We quantitatively analyzed airway changes (the inner luminal area, airway inner parameter, airway wall thickness, Pi10, skewness, and kurtosis) in the chest CT of fibrotic ILA patients, and the fibrotic ILA patients were categorized into groups based on pack-years: light, moderate, heavy. Airway change data and pulmonary function tests among the three groups of fibrotic ILA patients were compared with those of the control group by one-way ANOVA. Results: Mean skewness (2.58 ± 0.36) and kurtosis (7.64 ± 2.36) in the control group were significantly different from those of the fibrotic ILA patients (1.89 ± 0.37 and 3.62 ± 1.70, respectively, p < 0.001). In fibrotic ILA group, only heavy smokers had significantly increased Pi10 (mean increase 0.04, p = 0.013), increased airway wall thickness of the segmental bronchi (mean increase 0.06 mm, p = 0.005), and decreased lung diffusing capacity for carbon monoxide (p = 0.023). Conclusion: Pi10, as a biomaker of quantitative CT in fibrotic ILA patients, can reveal that smoking affects airway remodeling. Full article
(This article belongs to the Special Issue Quantitative Imaging in Oncology)
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11 pages, 1286 KiB  
Article
Ipsilateral Recurrence of DCIS in Relation to Radiomics Features on Contrast Enhanced Breast MRI
by Ga Eun Park, Sung Hun Kim, Eun Byul Lee, Yoonho Nam and Wonmo Sung
Tomography 2022, 8(2), 596-606; https://doi.org/10.3390/tomography8020049 - 1 Mar 2022
Cited by 6 | Viewed by 3177
Abstract
The purpose of this retrospective study was to investigate the association between ipsilateral recurrence of ductal carcinoma in situ (DCIS) and radiomics features from DCIS and contralateral normal breast on contrast enhanced breast MR imaging. A total of 163 patients with DCIS who [...] Read more.
The purpose of this retrospective study was to investigate the association between ipsilateral recurrence of ductal carcinoma in situ (DCIS) and radiomics features from DCIS and contralateral normal breast on contrast enhanced breast MR imaging. A total of 163 patients with DCIS who underwent preoperative MR imaging between January 2010 and December 2014 were included (training cohort; n = 117, validation cohort; n = 46). Radiomics features were extracted from whole tumor volume of DCIS on early dynamic T1-subtraction images and from the contralateral normal breast on precontrast T1 and early dynamic T1-subtraction images. After feature selection, a Rad-score was established by LASSO Cox regression model. Performance of Rad-score was evaluated by the receiver operating characteristic (ROC) curve and Kaplan Meier curve with log rank test. The Rad-score was significantly associated with ipsilateral recurrence free survival (RFS). The low-risk group with a low Rad-score showed higher ipsilateral RFS than the high-risk group with a high Rad-score in both training and validation cohorts (p < 0.01). The Rad-score based on radiomics features from DCIS and contralateral normal breast on breast MR imaging showed the potential for prediction of ipsilateral RFS of DCIS. Full article
(This article belongs to the Special Issue Quantitative Imaging in Oncology)
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