Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury
Abstract
:1. Introduction
2. Materials and Methods
2.1. Experiment Protocols
2.2. Data Acquisition
2.3. MR Image Analysis
2.4. Biochemical Measurements and Histologic Evaluations
2.5. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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T2 (ms) | Group | Baseline | Day 2 | Day 4 | Day 6 |
---|---|---|---|---|---|
CO | AAN | 50.69 ± 2.79 | 53.98 ± 1.59 | 59.11 ± 0.68 ** | 61.96 ± 1.25 *** |
control | 52.57 ± 1.51 | 52.07 ± 1.33 | 52.39 ± 1.39 | 51.85 ± 1.59 | |
OSOM | AAN | 53.19 ± 1.26 | 58.74 ± 1.71 * | 63.44 ± 0.49 *** | 69.43 ± 2.37 *** |
control | 52.16 ± 0.85 | 52.15 ± 1.07 | 52.42 ± 1.13 | 51.88 ± 0.98 | |
ISOM | AAN | 64.87 ± 0.97 | 65.66 ± 1.63 | 67.99 ± 2.04 | 47.55 ± 4.84 * |
control | 66.14 ± 1.31 | 64.10 ± 0.46 | 63.99 ± 0.79 | 65.53 ± 0.90 | |
IM | AAN | 128.41 ± 3.01 | 141.91 ± 6.44 | 134.73 ± 12.21 | 103.79 ± 17.89 |
control | 128.85 ± 2.96 | 130.65 ± 2.52 | 130.52 ± 2.40 | 129.89 ± 3.47 |
ADC (10−3 mm2/s) | Group | Baseline | Day 2 | Day 4 | Day 6 |
---|---|---|---|---|---|
CO | AAN | 1.307 ± 0.09 | 1.319 ± 0.018 * | 1.311 ± 0.127 | 1.006 ± 0.139 * |
control | 1.489 ± 0.099 | 1.566 ± 0.086 | 1.541 ± 0.056 | 1.585 ± 0.108 | |
OSOM | AAN | 1.215 ± 0.083 | 1.256 ± 0.035 * | 1.295 ± 0.061 * | 0.975 ± 0.109 ** |
control | 1.374 ± 0.098 | 1.532 ± 0.098 | 1.557 ± 0.069 | 1.508 ± 0.121 | |
ISOM | AAN | 1.083 ± 0.079 | 1.142 ± 0.045 * | 1.027 ± 0.048 * | 0.809 ± 0.08 * |
control | 1.289 ± 0.106 | 1.417 ± 0.092 | 1.426 ± 0.062 | 1.451 ± 0.124 | |
IM | AAN | 1.393 ± 0.091 | 1.416 ± 0.03 | 1.372 ± 0.124 | 1.161 ± 0.146 * |
control | 1.55 ± 0.094 | 1.654 ± 0.095 | 1.64 ± 0.055 | 1.688 ± 0.141 |
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Mei, Y.; Yang, G.; Guo, Y.; Zhao, K.; Wu, S.; Xu, Z.; Zhou, S.; Yan, C.; Seeliger, E.; Niendorf, T.; et al. Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury. Tomography 2022, 8, 2902-2914. https://doi.org/10.3390/tomography8060243
Mei Y, Yang G, Guo Y, Zhao K, Wu S, Xu Z, Zhou S, Yan C, Seeliger E, Niendorf T, et al. Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury. Tomography. 2022; 8(6):2902-2914. https://doi.org/10.3390/tomography8060243
Chicago/Turabian StyleMei, Yingjie, Guixiang Yang, Yihao Guo, Kaixuan Zhao, Shuyu Wu, Zhongbiao Xu, Shan Zhou, Chenggong Yan, Erdmann Seeliger, Thoralf Niendorf, and et al. 2022. "Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury" Tomography 8, no. 6: 2902-2914. https://doi.org/10.3390/tomography8060243