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Tomography, Volume 11, Issue 8

August 2025 - 12 articles

Cover Story:

Left: Demonstration of the molecular context of radioligands targeting (A) fibroblast activation protein (FAP); (B) hypoxia; (C) gastrin-releasing peptide receptor (GRPr); and (D) integrin. Each process is part of the complex tumor microenvironment, which allows for high tumor-to-background uptake ratios on PET imaging.
Right: Representative images obtained from a patient with non-small-cell lung cancer demonstrating radiotracer-avid primary lung neoplasm at the left lung apex (arrows). (A–B) Fluorine 18 (18F)-labeled Fluoromisonidazole (FMISO) PET/CT images. (A) 18F–FMISO axial PET image; (B) axial fused 18F-FMISO PET/CT image with an SUV max of 2.5. (C–D) Fluorine 18 (18F)-labeled Fluorodeoxyglucose (FDG) PET/CT images of the same patient performed 1 week prior. (C) 18F-FDG axial PET image; (D) axial fused 18F-FDG PET/CT image demonstrating intense avidity with an SUV max of 24. View this paper

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Articles (12)

  • Article
  • Open Access
1 Citations
1,922 Views
18 Pages

Contrast-Enhanced Mammography in Breast Lesion Assessment: Accuracy and Surgical Impact

  • Graziella Di Grezia,
  • Sara Mercogliano,
  • Luca Marinelli,
  • Antonio Nazzaro,
  • Alessandro Galiano,
  • Elisa Cisternino,
  • Gianluca Gatta,
  • Vincenzo Cuccurullo and
  • Mariano Scaglione

Background: Accurate preoperative tumor sizing is critical for optimal surgical planning in breast cancer. Contrast-enhanced mammography (CEM) has emerged as a promising modality, yet its accuracy relative to conventional imaging and pathology requir...

  • Communication
  • Open Access
1,211 Views
9 Pages

Differences in PI-RADS Classification of Prostate Cancer Based on mpMRI Scans Taken 6 Weeks Apart

  • Justine Schoch,
  • Viola Düring,
  • Michael Wiedmann,
  • Daniel Overhoff,
  • Daniel Dillinger,
  • Stephan Waldeck,
  • Hans-Ulrich Schmelz and
  • Tim Nestler

Objectives: This study aimed to investigate the consistency of lesion identification by Prostate Imaging Reporting and Data System (PI-RADS) and the related clinical and histological characteristics in a high-volume tertiary care center. Materials an...

  • Article
  • Open Access
987 Views
22 Pages

Background: Accurate subtype identification of lymphoma cancer is crucial for effective diagnosis and treatment planning. Although standard deep learning algorithms have demonstrated robustness, they are still prone to overfitting and limited general...

  • Article
  • Open Access
3 Citations
1,839 Views
38 Pages

Machine Learning and Feature Selection in Pediatric Appendicitis

  • John Kendall,
  • Gabriel Gaspar,
  • Derek Berger and
  • Jacob Levman

Background/Objectives: Accurate prediction of pediatric appendicitis diagnosis, management, and severity is critical for clinical decision-making. We aimed to evaluate the predictive performance of a wide range of machine learning models, combined wi...

  • Article
  • Open Access
730 Views
15 Pages

Background/Objectives: Fat and inflammation confound current magnetic resonance imaging (MRI) methods for assessing fibrosis in liver disease. Sodium or amide proton transfer-weighted MRI methods may be more specific for assessing liver fibrosis. The...

  • Article
  • Open Access
1,164 Views
20 Pages

Objectives: This study investigates whether scan time in the high-resolution magnetic resonance imaging (MRI) of human embryos can be reduced without compromising spatial resolution by applying zero-shot self-supervised learning (ZS-SSL), a deep-lear...

  • Article
  • Open Access
777 Views
23 Pages

Background/Objectives: There is significant interest in using texture features to extract hidden image-based information. In medical imaging applications using radiomics, AI, or personalized medicine, the quest is to extract patient or disease specif...

  • Article
  • Open Access
2 Citations
2,154 Views
16 Pages

Background: Despite the growing demand for amyloid PET quantification, practical challenges remain. As automated software platforms are increasingly adopted to address these limitations, we evaluated the reliability of commercial tools for Centiloid...

  • Review
  • Open Access
2,251 Views
13 Pages

Computed Tomography and Coronary Plaque Analysis

  • Hashim Alhammouri,
  • Ramzi Ibrahim,
  • Rahmeh Alasmar,
  • Mahmoud Abdelnabi,
  • Eiad Habib,
  • Mohamed Allam,
  • Hoang Nhat Pham,
  • Hossam Elbenawi,
  • Juan Farina and
  • Balaji Tamarappoo
  • + 4 authors

Advances in plaque imaging have transformed cardiovascular diagnostics through detailed characterization of atherosclerotic plaques beyond traditional stenosis assessment. This review outlines the clinical applications of varying modalities, includin...

  • Article
  • Open Access
792 Views
13 Pages

Background/Objectives: X-ray computed tomography (XCT) is a powerful tool for volumetric imaging, where three-dimensional (3D) images are generated from a large number of individual X-ray projection images. However, collecting the required number of...

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Tomography - ISSN 2379-139X