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Bioengineering, Volume 9, Issue 2

February 2022 - 43 articles

Cover Story: The established structure-property relationship and biochemical composition of major ampullate spider silk provides it with an impressive balance of strength and elasticity, unrivaled by synthetic materials. Other biologically inspired small peptide motifs correlated to specific functionalities can be combined with this unit to create designer silk material with new hybrid properties. Four concatenated repeats of the heparin-binding motif, ARKKAAKA, were genetically linked with MaSp2 amino acid motifs (GPGXXAn) to produce a mechanically robust protein capable of both binding biologically active heparin and resisting pathogen colonization, potentially enabling both in vivo anticoagulation and anti-infectivity. The anticoagulant activity of this fusion protein was comparable to the activity of surface-bound heparin. View this paper
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Articles (43)

  • Review
  • Open Access
219 Citations
24,352 Views
29 Pages

A New Wave of Industrialization of PHA Biopolyesters

  • Martin Koller and
  • Anindya Mukherjee

The ever-increasing use of plastics, their fossil origin, and especially their persistence in nature have started a wave of new innovations in materials that are renewable, offer the functionalities of plastics, and are biodegradable. One such class...

  • Article
  • Open Access
11 Citations
4,151 Views
17 Pages

PMMA-Cement-PLIF Is Safe and Effective as a Single-Stage Posterior Procedure in Treating Pyogenic Erosive Lumbar Spondylodiscitis—A Single-Center Retrospective Study of 73 Cases

  • Moritz Caspar Deml,
  • Emmanuelle N. Cattaneo,
  • Sebastian Frederick Bigdon,
  • Hans-Jörg Sebald,
  • Sven Hoppe,
  • Paul Heini,
  • Lorin Michael Benneker and
  • Christoph Emanuel Albers

Background: Surgical treatment for erosive pyogenic spondylodiscitis of the lumbar spine is challenging as, following debridement of the intervertebral and bony abscess, a large and irregular defect is created. Sufficient defect reconstruction with c...

  • Review
  • Open Access
53 Citations
9,303 Views
16 Pages

Vaccination is one of the key strategies to stop the COVID-19 pandemic. This review aims to evaluate the current state of vaccine development and to determine the issues that merit additional research. We conducted a literature review of the developm...

  • Article
  • Open Access
3 Citations
3,523 Views
18 Pages

Biologically Inspired Optimal Terminal Iterative Learning Control for the Swing Phase of Gait in a Hybrid Neuroprosthesis: A Modeling Study

  • Nathaniel S. Makowski,
  • Marshaun N. Fitzpatrick,
  • Ronald J. Triolo,
  • Ryan-David Reyes,
  • Roger D. Quinn and
  • Musa Audu

(1) Background: An iterative learning control (ILC) strategy was developed for a “Muscle First” Motor-Assisted Hybrid Neuroprosthesis (MAHNP). The MAHNP combines a backdrivable exoskeletal brace with neural stimulation technology to enabl...

  • Article
  • Open Access
11 Citations
3,977 Views
16 Pages

In this work, we describe a new method to detect periods of eating by tracking wrist motion during everyday life. Eating uses hand-to-mouth gestures for ingestion, each of which lasts a few seconds. Previous works have detected these gestures individ...

  • Review
  • Open Access
48 Citations
10,195 Views
19 Pages

C. militaris is an insect-born fungus that belongs to Ascomycota and Cordyceps. It has a variety of biological activities that can be applied in medicine, health-care products, cosmeceuticals and other fields. Cordycepin (COR) is one of the major bio...

  • Review
  • Open Access
22 Citations
8,753 Views
10 Pages

Ankle sprains are generally the most common injuries that are frequently experienced by competitive athletes. Ankle sprains, which are the main cause of ankle instability, can impair long-term sports performance and cause chronic ankle instability (C...

  • Article
  • Open Access
1 Citations
3,122 Views
13 Pages

An Immersible Microgripper for Pancreatic Islet and Organoid Research

  • Eike Früh,
  • Sebastian Bütefisch,
  • Benjamin Gursky,
  • Dennis Brüning,
  • Monika Leester-Schädel,
  • Andreas Dietzel and
  • Ingo Rustenbeck

To improve the predictive value of in vitro experimentation, the use of 3D cell culture models, or organoids, is becoming increasingly popular. However, the current equipment of life science laboratories has been developed to deal with cell monolayer...

  • Article
  • Open Access
19 Citations
13,238 Views
15 Pages

Alginate Core–Shell Capsules for 3D Cultivation of Adipose-Derived Mesenchymal Stem Cells

  • Sabrina Nebel,
  • Manuel Lux,
  • Sonja Kuth,
  • Faina Bider,
  • Wolf Dietrich,
  • Dominik Egger,
  • Aldo R. Boccaccini and
  • Cornelia Kasper

Mesenchymal stem cells (MSCs) are primary candidates in tissue engineering and stem cell therapies due to their intriguing regenerative and immunomodulatory potential. Their ability to self-assemble into three-dimensional (3D) aggregates further impr...

  • Review
  • Open Access
11 Citations
8,961 Views
24 Pages

As medicine advances and physicians are able to provide patients with innovative solutions, including placement of temporary or permanent medical devices that drastically improve quality of life of the patient, there is the persistent, recurring prob...

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Bioengineering - ISSN 2306-5354