Special Issue "Strategies for the Efficient Development of Microbial Bioprocesses"

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Prof. Dr. Peter Neubauer
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Guest Editor
Department of Bioprocess Engineering, Technische Universität Berlin, Ackerstraβe 76, ACK24, D-13355 Berlin, Germany
Interests: bioprocess development; Escherichia coli physiology; recombinant proteins; cocultivation; fed-batch; continuous culture
Special Issues and Collections in MDPI journals
Prof. Dr. Christoph Herwig
E-Mail Website
Guest Editor
Department of Chemical Engineering, Research Area Biochemical Engineering, Vienna University of Technology, 1040 Vienna, Austria
Interests: integrated bioprocess development; monitoring; modeling and control of bioprocesses; data–information–knowledge; scale down models
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The consistent development of new bioprocesses needs to be performed at the perspective of the final process scale. Therefore, an efficient bioprocess development should consider large‑scale effects and integrate them from early stages onwards together with process analytical technologies (PAT) and quality by design (QbD). This includes technical challenges (sensors, modelling), the cellular dynamic regulatory networks and population dynamics. Current progresses in automation and parallelization demand for a higher degree of digitalization and advanced data treatment. The aim of this Special Issue is to discuss the efficiency of the whole product and process life cycle, from the raw materials and early screening stages to industrial scale production and final application. This Special Issue is a joint project of the journals Microorganisms and Bioengineering and focusses on contributions at the 6th BioProScale Symposium, which was organised as a digital event from March 29–31, 2021, but further contributions are also invited on the following subjects:

Industrial-scale bioprocessing (scale-down and scale-up approaches, industrial-scale operation, population heterogeneity, process monitoring and advanced control, modelling of industrial-scale processes, mixing and reactor characterization, process robustness and repeatability, integrated upstream and downstream operations), process analytical technologies (PAT, multiparameter analysis, non-invasive sensors, single-cell based monitoring, soft sensors, fault identification and diagnosis, multiposition measurements, data handling and exploration, monitoring and control of co- and mixed cultures), high-throughput bioprocessing and automation (lab automation and robotics, automated screenings in bioprocess development, DoE, model‑based experimental designs, algorithm based operations and operational space characterisation, evolutionary strategies for strains and processes, communication trends for dynamic device operation and data flow, high-throughput strain engineering) and bioprocesses for a circular economy (waste streams to value-added products, pretreatment, feedstock flexibility, scale-up/scale-down of biorefinery concepts, closed carbon cycles, smart bioproduction grids, decentralised production).

The papers related to microbiology are welcome for Microorganisms, related to engineering and other fields are welcome for Bioengineering. The Joint Special Issue in Microorganisms: Strategies for the Efficient Development of Microbial Bioprocesses

Prof. Dr. Peter Neubauer
Prof. Dr. Christoph Herwig
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Prof. Dr. Peter Neubauer
Prof. Dr. Christoph Herwig
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Article
TCA Cycle and Its Relationship with Clavulanic Acid Production: A Further Interpretation by Using a Reduced Genome-Scale Metabolic Model of Streptomyces clavuligerus
Bioengineering 2021, 8(8), 103; https://doi.org/10.3390/bioengineering8080103 - 22 Jul 2021
Viewed by 186
Abstract
Streptomyces clavuligerus (S. clavuligerus) has been widely studied for its ability to produce clavulanic acid (CA), a potent inhibitor of β-lactamase enzymes. In this study, S. clavuligerus cultivated in 2D rocking bioreactor in fed-batch operation produced CA at comparable rates to [...] Read more.
Streptomyces clavuligerus (S. clavuligerus) has been widely studied for its ability to produce clavulanic acid (CA), a potent inhibitor of β-lactamase enzymes. In this study, S. clavuligerus cultivated in 2D rocking bioreactor in fed-batch operation produced CA at comparable rates to those observed in stirred tank bioreactors. A reduced model of S. clavuligerus metabolism was constructed by using a bottom-up approach and validated using experimental data. The reduced model was implemented for in silico studies of the metabolic scenarios arisen during the cultivations. Constraint-based analysis confirmed the interrelations between succinate, oxaloacetate, malate, pyruvate, and acetate accumulations at high CA synthesis rates in submerged cultures of S. clavuligerus. Further analysis using shadow prices provided a first view of the metabolites positive and negatively associated with the scenarios of low and high CA production. Full article
(This article belongs to the Special Issue Strategies for the Efficient Development of Microbial Bioprocesses)
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