Synthesis, Characterization, and Application of Biomacromolecules and Biobased Polymers

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 871

Special Issue Editors


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Guest Editor
Department of Chemical and NanoEngineering, University of California San Diego, La Jolla, CA, USA
Interests: nanomedicine; biosensors; biomedical engineering; wearable healthcare; nanotechnology
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Co-Guest Editor
School of Environment and Chemical Engineering, Xi'an Polytechnic University, Xi'an, China
Interests: supramolecular self-assembly; cation-π chemistry; biomaterial science; nanobiotechnology; Pt(II) metallacycles

Special Issue Information

Dear Colleagues,

Biomacromolecules and biobased polymers encompass a diverse range of large molecular substances found in biological organisms, including nucleic acids (polynucleotides), proteins (polypeptides), carbohydrates (glucans or polysaccharides) and lipids. These substances have attracted significant attention in the biopharmaceutical field due to their natural properties such as high biocompatibility, biodegradability, low immunogenicity and efficient targeting capabilities. Moreover, as environmentally friendly materials, biomacromolecules and biobased polymers are easily degradable and renewable, offering potential solutions to global energy depletion issues. Despite their promising properties, challenges exist in replacing traditional polymers with these substances for advanced materials, including issues with stability, high extraction costs and limited processability. Efforts in optimized design synthesis aim to enhance the stability and delivery capacity of these biological materials, making them more accessible and cost-effective. This research is expanding their applications across diverse fields such as biopharmaceuticals, tissue engineering, biosensors, environmental protection, bioinformatics, bioengineering and materials science, representing a current research frontier.

We invite contributions to this focused Special Issue and encourage you to share this information with colleagues and peers who may be interested in this topic.

Dr. Shichao Ding
Dr. Wenzhuo Chen
Guest Editors

Manuscript Submission Information

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Keywords

  • biomacromolecules
  • biobased polymers
  • synthesis
  • characterization
  • engineered biomaterial
  • biopharmaceuticals

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Published Papers (1 paper)

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Research

17 pages, 5800 KB  
Article
3D Printing of Shape Memory Resin for Orthodontic Aligners with Green Synthesized Antimicrobial ZnO Nanoparticles Coatings: Toward Bioactive Devices
by Airy Teramoto-lida, Rafael Álvarez-Chimal, Lorena Reyes-Carmona, Marco Antonio Álvarez-Pérez, Amaury Pozos-Guillen and Febe Carolina Vázquez-Vázquez
Bioengineering 2025, 12(11), 1193; https://doi.org/10.3390/bioengineering12111193 - 1 Nov 2025
Viewed by 261
Abstract
The development of bioactive dental materials with antimicrobial and biocompatible properties is important for improving clinical outcomes and reducing complications associated with intraoral devices. This study presents a novel approach that combines a 3D-printed shape-memory resin (TC-85DAC) with green-synthesized zinc oxide nanoparticles (ZnO [...] Read more.
The development of bioactive dental materials with antimicrobial and biocompatible properties is important for improving clinical outcomes and reducing complications associated with intraoral devices. This study presents a novel approach that combines a 3D-printed shape-memory resin (TC-85DAC) with green-synthesized zinc oxide nanoparticles (ZnO NPs) to enhance biological performance. ZnO NPs were synthesized using Dysphania ambrosioides extract, producing quasi-spherical particles with a crystalline hexagonal structure and sizes between 15 and 40 nm. Resin discs were coated with ZnO NPs at 10%, 20%, and 30%, then assessed for biocompatibility with human gingival fibroblasts and antibacterial activity against Porphyromonas gingivalis and Streptococcus mutans. Surface roughness was also considered with and without ZnO NPs. Biocompatibility assays revealed a concentration- and time-dependent increase in cell viability, with the highest values at 30% ZnO NPs after 72 h of exposure to the NPs. Antibacterial testing confirmed the inhibition of both species, with Porphyromonas gingivalis showing greater sensitivity. Surface roughness increased with higher ZnO NPs concentrations, significantly influencing biological interactions. The integration of green-synthesized ZnO NPs with shape-memory resin produced a multifunctional dental material with improved bioactivity. This sustainable strategy enables bioactive coatings on 3D-printed resins, with potential applications in the next generation of smart dental devices. Full article
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