Machine Learning and Artificial Intelligence in Pediatric Healthcare

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biosignal Processing".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 991

Special Issue Editor


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Guest Editor
Division of Pediatric Critical Care, Cleveland Clinic Children’s, Cleveland, OH 44195, USA
Interests: pediatrics; critical care medicine; ICU; health systems research; sepsis; ARDS; respiratory failure; septic shock; artificial intelligence; machine learning; ECMO

Special Issue Information

Dear Colleagues,

The integration of machine learning (ML) and artificial intelligence (AI) into pediatric healthcare represents a transformative shift in how we diagnose, prognosticate, and treat conditions in children. Pediatric patients present unique clinical challenges, including developmental variability, ethical considerations, and limited availability of diverse datasets. These challenges require innovative solutions that ML and AI are uniquely positioned to address, leveraging their ability to analyze complex patterns in vast datasets and deliver actionable insights.

This Special Issue, entitled "Machine Learning and Artificial Intelligence in Pediatric Healthcare", will showcase cutting-edge research and reviews that highlight the applications, methodologies, and challenges of ML and AI in advancing pediatric care. Contributions are invited that explore the development and validation of AI and ML-driven diagnostic tools, prognostic models for critical and chronic pediatric conditions, and AI-based strategies for personalized therapeutic planning. We also welcome submissions addressing the ethical, regulatory, and implementation challenges associated with ML and AI in pediatrics.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Diagnostic and prognostic models for pediatric diseases using AI/ML;
  • Applications of explainable AI in pediatric clinical decision-making;
  • Innovative ML techniques for small and imbalanced pediatric datasets;
  • AI-enhanced imaging and wearable sensor applications in pediatric care;
  • Ethical and regulatory frameworks for ML in pediatric healthcare;
  • Real-world implementation and integration of AI/ML systems in pediatric clinical workflows;
  • Advances in federated learning for secure and scalable pediatric healthcare applications;
  • AI applications in improving outcomes for pediatric rare diseases and under-represented populations.

This Special Issue builds on the growing body of evidence showcasing how ML can improve diagnostic precision, reduce healthcare disparities, and optimize care delivery in pediatric populations. We anticipate that the insights and methodologies presented will help to shape the future of pediatric healthcare, ensuring equitable and effective AI-driven solutions for all children.

We look forward to receiving your contributions to this exciting and rapidly evolving field.

Dr. Hammad Ashraf Ganatra
Guest Editor

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Keywords

  • artificial intelligence
  • machine learning
  • pediatrics
  • natural language processing
  • diagnostics

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Published Papers (1 paper)

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Research

27 pages, 3905 KB  
Article
Linking a Deep Learning Model for Concussion Classification with Reorganization of Large-Scale Brain Networks in Female Youth
by Julianne McLeod, Karun Thanjavur, Sahar Sattari, Arif Babul, D. T. Hristopulos and Naznin Virji-Babul
Bioengineering 2025, 12(9), 986; https://doi.org/10.3390/bioengineering12090986 (registering DOI) - 17 Sep 2025
Abstract
Concussion, or mild traumatic brain injury, is a significant public health challenge, with females experiencing high rates and prolonged symptoms. Reliable and objective tools for early diagnosis are critically needed, particularly in pediatric populations, where subjective symptom reporting can be inconsistent and neurodevelopmental [...] Read more.
Concussion, or mild traumatic brain injury, is a significant public health challenge, with females experiencing high rates and prolonged symptoms. Reliable and objective tools for early diagnosis are critically needed, particularly in pediatric populations, where subjective symptom reporting can be inconsistent and neurodevelopmental factors may influence presentation. Five minutes of resting-state (RS) EEG data were collected from non-concussed and concussed females between 15 and 24 years of age. We first applied a deep learning approach to classify concussion directly from raw, RS electroencephalography (EEG) data. A long short-term memory (LSTM) recurrent neural network trained on the raw data achieved 84.2% accuracy and an ensemble median area under the receiver operating characteristic curve (AUC) of 0.904. To complement these results, we examined causal connectivity at the source level using information flow rate to explore potential network-level changes associated with concussion. Effective connectivity in the non-concussed cohort was characterized by a symmetric pattern along the central–parietal midline; in contrast, the concussed group showed a more posterior and left-lateralized pattern. These spatial distribution changes were accompanied by significantly higher connection magnitudes in the concussed group (p < 0.001). While these connectivity changes may not directly drive classification, they provide evidence of large-scale brain reorganization following concussion. Together, our results suggest that deep learning models can detect concussion with high accuracy, while connectivity analyses may offer complementary mechanistic insights. Future work with larger datasets is necessary to refine the model specificity, explore subgroup differences related to hormone cycle changes and symptoms, and incorporate data across different sports. Full article
(This article belongs to the Special Issue Machine Learning and Artificial Intelligence in Pediatric Healthcare)
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