Processes, Volume 6, Issue 2 (February 2018) – 10 articles
Cover Story (view full-size image): Cell-to-cell variability exists to some degree in any given cell population. In this work, we propose a method for performing sensitivity analysis of cell population dynamics, called Molecular Density Function Perturbation (MDFP). We apply MDFP to a mathematical model of programmed cell death (apoptosis) signaling pathway in HeLa cell population, to elucidate the molecules governing apoptosis decision making. The picture shows cell-to-cell variability in apoptosis, where cells of different colors illustrate cell populations from different time points. The picture also shows the apoptosis signaling network and the probability density functions of cleaved poly (ADP-ribose) polymerase concentration, a marker of apoptosis. View this paper
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