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Biomolecules, Volume 11, Issue 3

March 2021 - 146 articles

 

Cover Story: Circadian rhythm and the molecules involved in it, such as melanopsin and melatonin, play a key role in the eye to regulate homeostasis and even to treat some ocular conditions. As a result, many ocular pathologies, such as dry eye, corneal wound healing, cataracts, myopia, retinal diseases and glaucoma, are affected by this cycle. This review summarizes the current scientific literature about the influence of circadian patterns on the eye, focusing on its relationship with increased intraocular pressure and glaucoma. Further study is required on whether these treatments could improve their effect when posology is established in function of circadian patterns, as well as on if new drugs such as melatonin or its analogs, which are related to the circadian rhythm, not only could be used as the main treatment but as coadjutant, improving the circadian pattern or its antioxidant and antiangiogenic effect. View this paper
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Articles (146)

  • Article
  • Open Access
18 Citations
3,873 Views
13 Pages

Cerrena unicolor Laccases, Genes Expression and Regulation of Activity

  • Anna Pawlik,
  • Beata Ciołek,
  • Justyna Sulej,
  • Andrzej Mazur,
  • Przemysław Grela,
  • Magdalena Staszczak,
  • Mateusz Niścior,
  • Magdalena Jaszek,
  • Anna Matuszewska and
  • Grzegorz Janusz
  • + 1 author

22 March 2021

A white rot fungus Cerrena unicolor has been identified as an important source of laccase, unfortunately regulation of this enzyme genes expression is poorly understood. Using 1D and 2D PAGE and LC-MS/MS, laccase isoenzymes were investigated in the l...

  • Article
  • Open Access
76 Citations
5,850 Views
17 Pages

The Antimicrobial, Antioxidant, and Anticancer Activity of Greenly Synthesized Selenium and Zinc Composite Nanoparticles Using Ephedra aphylla Extract

  • Mustafa Mohsen El-Zayat,
  • Mostafa M. Eraqi,
  • Hani Alrefai,
  • Ayman Y. El-Khateeb,
  • Marwan A. Ibrahim,
  • Hashim M. Aljohani,
  • Maher M. Aljohani and
  • Moustafa Mohammed Elshaer

22 March 2021

The current work aimed to synthesize selenium and zinc nanoparticles using the aqueous extract of Ephedra aphylla as a valuable medicinal plant. The prepared nanoparticles were characterized by TEM, zeta potential, and changes in the phytochemical co...

  • Article
  • Open Access
92 Citations
11,155 Views
17 Pages

Deep Learning for Novel Antimicrobial Peptide Design

  • Christina Wang,
  • Sam Garlick and
  • Mire Zloh

22 March 2021

Antimicrobial resistance is an increasing issue in healthcare as the overuse of antibacterial agents rises during the COVID-19 pandemic. The need for new antibiotics is high, while the arsenal of available agents is decreasing, especially for the tre...

  • Article
  • Open Access
13 Citations
4,462 Views
19 Pages

Differential MicroRNA Expression Involved in Endometrial Receptivity of Goats

  • Xupeng Zang,
  • Chen Zhou,
  • Wenjing Wang,
  • Jianyu Gan,
  • Yaokun Li,
  • Dewu Liu,
  • Guangbin Liu and
  • Linjun Hong

22 March 2021

Endometrial receptivity represents one of the leading factors affecting the successful implantation of embryos during early pregnancy. However, the mechanism of microRNAs (miRNAs) to establish goat endometrial receptivity remains unclear. This study...

  • Feature Paper
  • Review
  • Open Access
25 Citations
6,557 Views
21 Pages

Coupling Machine Learning and Lipidomics as a Tool to Investigate Metabolic Dysfunction-Associated Fatty Liver Disease. A General Overview

  • Helena Castañé,
  • Gerard Baiges-Gaya,
  • Anna Hernández-Aguilera,
  • Elisabet Rodríguez-Tomàs,
  • Salvador Fernández-Arroyo,
  • Pol Herrero,
  • Antoni Delpino-Rius,
  • Nuria Canela,
  • Javier A. Menendez and
  • Jordi Camps
  • + 1 author

22 March 2021

Hepatic biopsy is the gold standard for staging nonalcoholic fatty liver disease (NAFLD). Unfortunately, accessing the liver is invasive, requires a multidisciplinary team and is too expensive to be conducted on large segments of the population. NAFL...

  • Review
  • Open Access
44 Citations
7,278 Views
17 Pages

Antiviral Cyanometabolites—A Review

  • Hanna Mazur-Marzec,
  • Marta Cegłowska,
  • Robert Konkel and
  • Krzysztof Pyrć

22 March 2021

Global processes, such as climate change, frequent and distant travelling and population growth, increase the risk of viral infection spread. Unfortunately, the number of effective and accessible medicines for the prevention and treatment of these in...

  • Article
  • Open Access
9 Citations
3,232 Views
16 Pages

In Vitro Preformed Biofilms of Bacillus safensis Inhibit the Adhesion and Subsequent Development of Listeria monocytogenes on Stainless-Steel Surfaces

  • Anne-Sophie Hascoët,
  • Carolina Ripolles-Avila,
  • Brayan R. H. Cervantes-Huamán and
  • José Juan Rodríguez-Jerez

22 March 2021

Listeria monocytogenes continues to be one of the most important public health challenges for the meat sector. Many attempts have been made to establish the most efficient cleaning and disinfection protocols, but there is still the need for the secto...

  • Article
  • Open Access
7 Citations
4,542 Views
14 Pages

Metabolic Changes of Cholangiocarcinoma Cells in Response to Coniferyl Alcohol Treatment

  • Bundit Promraksa,
  • Praewpan Katrun,
  • Jutarop Phetcharaburanin,
  • Yingpinyapat Kittirat,
  • Nisana Namwat,
  • Anchalee Techasen,
  • Jia V. Li and
  • Watcharin Loilome

22 March 2021

Cholangiocarcinoma (CCA) is a major cause of mortality in Northeast Thailand with about 14,000 deaths each year. There is an urgent necessity for novel drug discovery to increase effective treatment possibilities. A recent study reported that lignin...

  • Article
  • Open Access
65 Citations
4,938 Views
24 Pages

Silymarin-Enriched Biostimulant Foliar Application Minimizes the Toxicity of Cadmium in Maize by Suppressing Oxidative Stress and Elevating Antioxidant Gene Expression

  • Hesham F. Alharby,
  • Hassan S. Al-Zahrani,
  • Khalid R. Hakeem,
  • Hameed Alsamadany,
  • El-Sayed M. Desoky and
  • Mostafa M. Rady

21 March 2021

For maize, the potential preventive role of foliar spraying with an extract derived from maize grain (MEg, 2%), silymarin (Sm, 0.5 mM), or silymarin-enriched MEg (MEg-Sm) in attenuating the stress effects of cadmium (Cd, 0.5 mM) was examined using a...

  • Review
  • Open Access
37 Citations
9,730 Views
29 Pages

Neuropathology of Animal Prion Diseases

  • Leonor Orge,
  • Carla Lima,
  • Carla Machado,
  • Paula Tavares,
  • Paula Mendonça,
  • Paulo Carvalho,
  • João Silva,
  • Maria de Lurdes Pinto,
  • Estela Bastos and
  • Jorge Cláudio Pereira
  • + 12 authors

21 March 2021

Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a fatal group of infectious, inherited and spontaneous neurodegenerative diseases affecting human and animals. They are caused by the conversion of cellular prion protein (PrPC) i...

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Biomolecules - ISSN 2218-273X