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Biomolecules, Volume 10, Issue 8

August 2020 - 114 articles

Cover Story: Zinc homeostasis is critical for bacterial survival and virulence. Extracellular zinc-binding proteins play an important role in this process. The ATP-binding cassette (ABC) transporter system AztABCD includes two periplasmic proteins, AztC and AztD. Both bind zinc with high affinity and specificity. Further, AztD can transfer zinc to AztC, which can then deliver the metal to the membrane permease (AztB) for import into the cell. These processes are highly specific and rely on conserved structural features of each protein. This work assesses the role of several flexible or unstructured sequences in zinc binding and transfer from AztD to AztC. The results provide insights into the dynamic nature of these processes and support a previously proposed structural model of transfer. View this paper.
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Articles (114)

  • Review
  • Open Access
103 Citations
7,184 Views
26 Pages

Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer

  • Milad Ashrafizadeh,
  • Kiavash Hushmandi,
  • Mehrdad Hashemi,
  • Mohammad Esmaeil Akbari,
  • Peter Kubatka,
  • Mehdi Raei,
  • Lenka Koklesova,
  • Md Shahinozzaman,
  • Reza Mohammadinejad and
  • Masoud Najafi
  • + 3 authors

7 August 2020

Bladder cancer (BC) is the 11th most common diagnosed cancer, and a number of factors including environmental and genetic ones participate in BC development. Metastasis of BC cells into neighboring and distant tissues significantly reduces overall su...

  • Review
  • Open Access
23 Citations
7,141 Views
27 Pages

7 August 2020

The ribonome interconnects the proteome and the transcriptome. Specific biology is situated at this interface, which can be studied in bulk using omics approaches or specifically by targeting an individual protein or RNA species. In this review, we f...

  • Feature Paper
  • Article
  • Open Access
5 Citations
3,944 Views
22 Pages

The CARF Protein MM_0565 Affects Transcription of the Casposon-Encoded cas1-solo Gene in Methanosarcina mazei Gö1

  • Andrea Ulbricht,
  • Lisa Nickel,
  • Katrin Weidenbach,
  • Herman Vargas Gebauer,
  • Claudia Kießling,
  • Konrad U. Förstner and
  • Ruth A. Schmitz

7 August 2020

Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) loci are found in bacterial and archaeal genomes where they provide the molecular machinery for acquisition of immunity against foreign DNA. In addition to the cas genes fundamentally...

  • Article
  • Open Access
27 Citations
4,273 Views
20 Pages

Prediction of Potential Ionic Liquids (ILs) for the Solid–Liquid Extraction of Docosahexaenoic Acid (DHA) from Microalgae Using COSMO-RS Screening Model

  • Shiva Rezaei Motlagh,
  • Razif Harun,
  • Dayang Radiah Awang Biak,
  • Siti Aslina Hussain,
  • Amal A. Elgharbawy,
  • Ramin Khezri and
  • Cecilia Devi Wilfred

6 August 2020

This study performs a screening of potential Ionic Liquids (ILs) for the extraction of Docosahexaenoic Acid (DHA) compounds by the calculation of capacity values. For this purpose, a Conductor-Like Screening Model for Real Solvents (COSMO-RS) was emp...

  • Review
  • Open Access
56 Citations
8,824 Views
30 Pages

6 August 2020

The etiological factors of oral cancer are complex including drinking alcohol, smoking tobacco, betel quid chewing, human papillomavirus infection, and nutritional deficiencies. Understanding the molecular mechanism of oral cancer is vital. The tradi...

  • Review
  • Open Access
22 Citations
5,558 Views
32 Pages

6 August 2020

Adult neurogenesis—resulting in adult-generated functioning, integrated neurons—is still one of the most captivating research areas of neuroplasticity. The addition of new neurons in adulthood follows a seemingly consistent multi-step pro...

  • Communication
  • Open Access
6 Citations
3,120 Views
13 Pages

Folding of Truncated Granulin Peptides

  • Rozita Takjoo,
  • David Wilson,
  • Paramjit S. Bansal,
  • Alex Loukas,
  • Michael J. Smout and
  • Norelle L. Daly

6 August 2020

Granulins are a family of unique protein growth factors which are found in a range of species and have several bioactivities that include cell proliferation and wound healing. They typically contain six disulfide bonds, but the sequences, structures...

  • Review
  • Open Access
12 Citations
4,864 Views
19 Pages

6 August 2020

One of the basic building blocks of all life forms are lipids—biomolecules that dissolve in nonpolar organic solvents but not in water. Lipids have numerous structural, metabolic, and regulative functions in health and disease; thus, complex ne...

  • Review
  • Open Access
48 Citations
6,468 Views
36 Pages

Essentials Oils from Brazilian Eugenia and Syzygium Species and Their Biological Activities

  • Jamile S. da Costa,
  • Ellen de Nazaré S. da Cruz,
  • William N. Setzer,
  • Joyce Kelly do R. da Silva,
  • José Guilherme S. Maia and
  • Pablo Luis B. Figueiredo

6 August 2020

The Eugenia and Syzygium genera include approximately 1000 and 1800 species, respectively, and both belong to the Myrtaceae. Their species present economic and medicinal importance and pharmacological properties. Due to their chemical diversity and b...

  • Review
  • Open Access
326 Citations
20,959 Views
24 Pages

Microalgae: A Promising Source of Valuable Bioproducts

  • Vyacheslav Dolganyuk,
  • Daria Belova,
  • Olga Babich,
  • Alexander Prosekov,
  • Svetlana Ivanova,
  • Dmitry Katserov,
  • Nikolai Patyukov and
  • Stanislav Sukhikh

6 August 2020

Microalgae are a group of autotrophic microorganisms that live in marine, freshwater and soil ecosystems and produce organic substances in the process of photosynthesis. Due to their high metabolic flexibility, adaptation to various cultivation condi...

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Biomolecules - ISSN 2218-273X