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Review

Hormonal Regulation of Mammalian Adult Neurogenesis: A Multifaceted Mechanism

1
Behavioral Science Department, Utah Valley University, Orem, UT 84058, USA
2
Psychology Department and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(8), 1151; https://doi.org/10.3390/biom10081151
Received: 28 June 2020 / Revised: 27 July 2020 / Accepted: 1 August 2020 / Published: 6 August 2020
(This article belongs to the Special Issue Hormonal Regulation of Neurogenesis in Adults)
Adult neurogenesis—resulting in adult-generated functioning, integrated neurons—is still one of the most captivating research areas of neuroplasticity. The addition of new neurons in adulthood follows a seemingly consistent multi-step process. These neurogenic stages include proliferation, differentiation, migration, maturation/survival, and integration of new neurons into the existing neuronal network. Most studies assessing the impact of exogenous (e.g., restraint stress) or endogenous (e.g., neurotrophins) factors on adult neurogenesis have focused on proliferation, survival, and neuronal differentiation. This review will discuss the multifaceted impact of hormones on these various stages of adult neurogenesis. Specifically, we will review the evidence for hormonal facilitation (via gonadal hormones), inhibition (via glucocorticoids), and neuroprotection (via recruitment of other neurochemicals such as neurotrophin and neuromodulators) on newly adult-generated neurons in the mammalian brain. View Full-Text
Keywords: adult neurogenesis; hormones; hippocampus; dentate gyrus adult neurogenesis; hormones; hippocampus; dentate gyrus
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MDPI and ACS Style

Jorgensen, C.; Wang, Z. Hormonal Regulation of Mammalian Adult Neurogenesis: A Multifaceted Mechanism. Biomolecules 2020, 10, 1151. https://doi.org/10.3390/biom10081151

AMA Style

Jorgensen C, Wang Z. Hormonal Regulation of Mammalian Adult Neurogenesis: A Multifaceted Mechanism. Biomolecules. 2020; 10(8):1151. https://doi.org/10.3390/biom10081151

Chicago/Turabian Style

Jorgensen, Claudia, and Zuoxin Wang. 2020. "Hormonal Regulation of Mammalian Adult Neurogenesis: A Multifaceted Mechanism" Biomolecules 10, no. 8: 1151. https://doi.org/10.3390/biom10081151

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