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Biomolecules, Volume 10, Issue 8

August 2020 - 114 articles

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Cover Story: Zinc homeostasis is critical for bacterial survival and virulence. Extracellular zinc-binding proteins play an important role in this process. The ATP-binding cassette (ABC) transporter system AztABCD includes two periplasmic proteins, AztC and AztD. Both bind zinc with high affinity and specificity. Further, AztD can transfer zinc to AztC, which can then deliver the metal to the membrane permease (AztB) for import into the cell. These processes are highly specific and rely on conserved structural features of each protein. This work assesses the role of several flexible or unstructured sequences in zinc binding and transfer from AztD to AztC. The results provide insights into the dynamic nature of these processes and support a previously proposed structural model of transfer. View this paper.

Articles (114)

  • Article
  • Open Access
28 Citations
4,039 Views
14 Pages

18 August 2020

The search for new compounds with antimalarial activity is urgent, as resistance to ones in the classical drug, has already been described in more than one continent. Compounds derived from 1,2,3-triazoles are effective against parasites and bacteria...

  • Article
  • Open Access
14 Citations
3,899 Views
15 Pages

CB2 Receptors and Neuron–Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition

  • Estefania Rojo-Bustamante,
  • Ignacio Íñigo-Marco,
  • Miguel Angel Abellanas,
  • Rodrigo Vinueza-Gavilanes,
  • Ana Baltanás,
  • Esther Luquin,
  • Montserrat Arrasate and
  • Maria S. Aymerich

18 August 2020

Monoacylglycerol lipase inhibition (MAGL) has emerged as an interesting therapeutic target for neurodegenerative disease treatment due to its ability to modulate the endocannabinoid system and to prevent the production of proinflammatory mediators. T...

  • Article
  • Open Access
16 Citations
5,191 Views
17 Pages

The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma

  • Andrea Reszegi,
  • Zsolt Horváth,
  • Katalin Karászi,
  • Eszter Regős,
  • Victoria Postniková,
  • Péter Tátrai,
  • András Kiss,
  • Zsuzsa Schaff,
  • Ilona Kovalszky and
  • Kornélia Baghy

18 August 2020

Decorin, the prototype member of the small leucine-rich proteoglycan gene family of extracellular matrix (ECM) proteins, acts as a powerful tumor suppressor by inducing the p21Waf1/Cip1 cyclin-dependent kinase inhibitor, as well as through its abilit...

  • Review
  • Open Access
58 Citations
7,441 Views
19 Pages

Mitochondrial Potassium Channels as Druggable Targets

  • Antoni Wrzosek,
  • Bartłomiej Augustynek,
  • Monika Żochowska and
  • Adam Szewczyk

18 August 2020

Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may h...

  • Article
  • Open Access
25 Citations
4,452 Views
18 Pages

Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3

  • Natini Jinawath,
  • Meng-Shin Shiao,
  • Pichaya Chanpanitkitchote,
  • Jisnuson Svasti,
  • Yoichi Furukawa and
  • Yusuke Nakamura

17 August 2020

Although gastric cancer is one of the most common causes of cancer death in the world, mechanisms underlying this type of tumor have not been fully understood. In this study, we found that IQGAP3, a member of the IQGAP gene family, was significantly...

  • Feature Paper
  • Review
  • Open Access
39 Citations
7,014 Views
33 Pages

Grapevine Cane Extracts: Raw Plant Material, Extraction Methods, Quantification, and Applications

  • María José Aliaño-González,
  • Tristan Richard and
  • Emma Cantos-Villar

17 August 2020

Grapevine canes are viticulture waste that is usually discarded without any further use. However, recent studies have shown that they contain significant concentrations of health-promoting compounds, such as stilbenes, secondary metabolites of plants...

  • Feature Paper
  • Article
  • Open Access
13 Citations
5,663 Views
17 Pages

A 3D Tissue Model of Traumatic Brain Injury with Excitotoxicity That Is Inhibited by Chronic Exposure to Gabapentinoids

  • Nicolas Rouleau,
  • Mattia Bonzanni,
  • Joshua D. Erndt-Marino,
  • Katja Sievert,
  • Camila G. Ramirez,
  • William Rusk,
  • Michael Levin and
  • David L. Kaplan

17 August 2020

Injury progression associated with cerebral laceration is insidious. Following the initial trauma, brain tissues become hyperexcitable, begetting further damage that compounds the initial impact over time. Clinicians have adopted several strategies t...

  • Review
  • Open Access
11 Citations
3,952 Views
13 Pages

Proteomic and Bioinformatic Profiling of Transporters in Higher Plant Mitochondria

  • Ian Max Møller,
  • R. Shyama Prasad Rao,
  • Yuexu Jiang,
  • Jay J. Thelen and
  • Dong Xu

16 August 2020

To function as a metabolic hub, plant mitochondria have to exchange a wide variety of metabolic intermediates as well as inorganic ions with the cytosol. As identified by proteomic profiling or as predicted by MU-LOC, a newly developed bioinformatics...

  • Article
  • Open Access
29 Citations
4,977 Views
14 Pages

16 August 2020

Catechin is a plant polyphenol with valuable antioxidant and health-promoting properties. Polymerization is one way to stabilize flavonoids and may cause changes in their specific properties. The aim of this study is to obtain a polymeric complex cat...

  • Review
  • Open Access
14 Citations
6,408 Views
36 Pages

Mitochondrial HMG-Box Containing Proteins: From Biochemical Properties to the Roles in Human Diseases

  • Veronika Vozáriková,
  • Nina Kunová,
  • Jacob A. Bauer,
  • Ján Frankovský,
  • Veronika Kotrasová,
  • Katarína Procházková,
  • Vladimíra Džugasová,
  • Eva Kutejová,
  • Vladimír Pevala and
  • Jozef Nosek
  • + 1 author

16 August 2020

Mitochondrial DNA (mtDNA) molecules are packaged into compact nucleo-protein structures called mitochondrial nucleoids (mt-nucleoids). Their compaction is mediated in part by high-mobility group (HMG)-box containing proteins (mtHMG proteins), whose a...

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