Energy Metabolism in Brown Adipose Tissue

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 403

Special Issue Editor


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Guest Editor
The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Interests: obesity and diabetes; lipid metabolism; brown adipose tissue; sympathetic innervation
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Special Issue Information

Dear Colleagues,

This Special Issue aims to deepen our understanding of the role and molecular mechanisms of energy metabolism in thermogenic fat tissues, including brown adipose tissue and beige fat, in relation to obesity and associated diseases, as well as its broader health impacts. Thermogenic fat tissue plays a crucial role in regulating energy homeostasis. Energy metabolism encompasses the breakdown of nutrients, metabolite production, energy storage and release, and the utilization of both metabolites and energy in physiological functions. An imbalance in energy metabolism can lead to adiposity and trigger a range of metabolic disorders, including fatty liver, insulin resistance, type 2 diabetes, cardiovascular disease, inflammation, and other related conditions.

Energy metabolism can be regulated at the organelle level and influenced by numerous molecular factors. Topics within the scope of this Special Issue include the molecular mechanisms underlying the effects of various metabolites in thermogenic fat tissue, the regulation of metabolite production, thermogenesis, glucose metabolism, glycolysis, lipid metabolism, fatty acid metabolism, and the functions of mitochondria and lipid droplets in fat tissue. Additional areas of interest include the role of nutritional supplements in managing thermogenic fat tissue function, the impact of different types of lipids in thermogenic fat, and ER stress and ion balance (such as Ca2+, Zn+, and Mn2+) in thermogenic fat tissue.

We invite the submission of various article types, including original research, reviews, and mini reviews, as contributions to this Special Issue.

Dr. Chuanhai Zhang
Guest Editor

Manuscript Submission Information

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Keywords

  • energy metabolism
  • thermogenic fat tissue
  • metabolites
  • mitochondrial function
  • ER stress

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Published Papers (1 paper)

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Research

12 pages, 1831 KiB  
Article
Intestinal Epithelial-Derived Exosomes Under Cold Stimulation Promote Adipose Thermogenesis
by Xue Han, Tiange Feng, Yaxu Yang, Ziming Zhu, Fangyu Shao, Lijun Sun, Yue Yin and Weizhen Zhang
Metabolites 2025, 15(5), 324; https://doi.org/10.3390/metabo15050324 - 14 May 2025
Viewed by 189
Abstract
Background: Whether intestinal epithelial cells can regulate distant adipose tissue remains a mystery. Methods: Cold-stimulated intestinal epithelial cell-derived exosomes (Cold IEC-Exo) play a pivotal role in enhancing adipose thermogenesis and metabolic homeostasis, as demonstrated in this study. Results: IEC-Exo can [...] Read more.
Background: Whether intestinal epithelial cells can regulate distant adipose tissue remains a mystery. Methods: Cold-stimulated intestinal epithelial cell-derived exosomes (Cold IEC-Exo) play a pivotal role in enhancing adipose thermogenesis and metabolic homeostasis, as demonstrated in this study. Results: IEC-Exo can accumulate in adipose tissue. Compared with IEC-Exo derived from room temperature mice (RT IEC-Exo), Cold IEC-Exo significantly enhanced the thermogenesis of adipose. In vitro, Cold IEC-Exo directly stimulated thermogenesis in primary adipocytes by elevating oxygen consumption rate, proton leak, and fatty acid uptake, with no effect on glucose uptake. Small RNA sequencing identified miR-674-3p as a key mediator enriched in Cold IEC-Exo. miR-674-3p mimicry replicated Cold IEC-Exo effects, augmenting Ucp1 expression, mitochondrial uncoupling, and fatty acid utilization in adipocytes. Local overexpression of miR-674-3p in BAT and sWAT via AAV in vivo enhanced thermogenesis and attenuated diet-induced glucose intolerance. Conclusions: These findings establish that Cold IEC-Exo, via miR-674-3p transfer, drive adipose thermogenic activation and mitigate metabolic dysfunction, highlighting their therapeutic potential in obesity-related disorders. Full article
(This article belongs to the Special Issue Energy Metabolism in Brown Adipose Tissue)
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