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Biology, Volume 10, Issue 4

April 2021 - 98 articles

Cover Story: Genome organization shapes the “traffic patterns" of transcriptional regulators. The DNA-binding protein, CCCTC-binding factor (CTCF) and the ring-shaped cohesin complex, regulate the three-dimensional (3D) organization of the genome by establishing chromatin loops that form topologically associating domains (TADs) and sub-TADs. To make DNA accessible or inaccessible to these players, ATP-dependent chromatin remodelers are likely required to mobilize the nucleosomes; however, studies elucidating the intersection between chromatin remodeling and 3D genome organization are only just emerging. This review highlights established and potential roles for specific remodelers in regulating various aspects of CTCF/cohesin-mediated genome organization. View this paper.
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Articles (98)

  • Article
  • Open Access
16 Citations
4,825 Views
30 Pages

Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry

  • Marcelo de M.A. Coura,
  • Eder A. Barbosa,
  • Guilherme D. Brand,
  • Carlos Bloch and
  • Joao B. de Sousa

20 April 2021

Colorectal cancer (CRC) ranks second as the leading cause of cancer-related deaths worldwide. N-glycosylation is one of the most common posttranslational protein modifications. Therefore, we studied the total serum N-glycome (TSNG) of 13 colon cancer...

  • Article
  • Open Access
11 Citations
3,619 Views
12 Pages

20 April 2021

This study reports the link between larvicidal activity and the phytochemical composition of male and female leaf extracts of Mercurialis annua L. (M. annua) from four Tunisian regions: Bizerte, Jandouba, Nabeul and Beja. Their antioxidant activity w...

  • Article
  • Open Access
22 Citations
4,321 Views
9 Pages

A New Approach to Quantifying Bioaccumulation of Elements in Biological Processes

  • Kinga Proc,
  • Piotr Bulak,
  • Monika Kaczor and
  • Andrzej Bieganowski

20 April 2021

Bioaccumulation, expressed as the bioaccumulation factor (BAF), is a phenomenon widely investigated in the natural environment and at laboratory scale. However, the BAF is more suitable for ecological studies, while in small-scale experiments it has...

  • Review
  • Open Access
34 Citations
8,942 Views
19 Pages

ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth

  • Christopher J. Gilbert,
  • Jacob Z. Longenecker and
  • Federica Accornero

20 April 2021

Integration of cellular responses to extracellular cues is essential for cell survival and adaptation to stress. Extracellular signal-regulated kinase (ERK) 1 and 2 serve an evolutionarily conserved role for intracellular signal transduction that pro...

  • Article
  • Open Access
3 Citations
3,538 Views
13 Pages

Quadruplex-Forming Motif Inserted into 3′UTR of Ty1his3-AI Retrotransposon Inhibits Retrotransposition in Yeast

  • Viktor Tokan,
  • Jose Luis Rodriguez Lorenzo,
  • Pavel Jedlicka,
  • Iva Kejnovska,
  • Roman Hobza and
  • Eduard Kejnovsky

20 April 2021

Guanine quadruplexes (G4s) serve as regulators of replication, recombination and gene expression. G4 motifs have been recently identified in LTR retrotransposons, but their role in the retrotransposon life-cycle is yet to be understood. Therefore, we...

  • Article
  • Open Access
34 Citations
5,519 Views
20 Pages

20 April 2021

Obesity caused by a high-fat diet (HFD) affects gut microbiota linked to the risk of type-2 diabetes (T2D). This study evaluates live cells and ethanolic extract (SEL) of Lactobacillus sakei Probio65 and Lactobacillus plantarum Probio-093 as natural...

  • Article
  • Open Access
14 Citations
4,005 Views
8 Pages

Blastocystis sp. Carriage and Irritable Bowel Syndrome: Is the Association Already Established?

  • Fernando Salvador,
  • Beatriz Lobo,
  • Lidia Goterris,
  • Carmen Alonso-Cotoner,
  • Javier Santos,
  • Elena Sulleiro,
  • Begoña Bailo,
  • David Carmena,
  • Adrián Sánchez-Montalvá and
  • Pau Bosch-Nicolau
  • + 3 authors

19 April 2021

Background: The aim of the present study is to describe the occurrence of Blastocystis sp. detection among asymptomatic subjects and patients with irritable bowel syndrome in order to evaluate the potential association between irritable bowel syndrom...

  • Article
  • Open Access
9 Citations
3,871 Views
13 Pages

Genetic Diversity in Diospyros Germplasm in the Western Caucasus Based on SSR and ISSR Polymorphism

  • Lidia S. Samarina,
  • Valentina I. Malyarovskaya,
  • Stefanie Reim,
  • Natalia G. Koninskaya,
  • Alexandra O. Matskiv,
  • Gregory A. Tsaturyan,
  • Ruslan S. Rakhmangulov,
  • Ruset M. Shkhalakhova,
  • Ekaterina S. Shurkina and
  • Raisa V. Kulyan
  • + 3 authors

19 April 2021

Persimmon germplasm in the Western Caucasus represent one of the most northerly collections. In our study, 51 commercial cultivars of D. kaki, 3 accessions of D. virginiana and 57 D. lotus accessions from six geographically distant populations were i...

  • Article
  • Open Access
4 Citations
4,456 Views
15 Pages

The Long-Term Effects of High-Fat and High-Protein Diets on the Metabolic and Endocrine Activity of Adipocytes in Rats

  • Ewa Pruszyńska-Oszmałek,
  • Małgorzata Wojciechowska,
  • Maciej Sassek,
  • Hanna Krauss,
  • Natalia Leciejewska,
  • Dawid Szczepankiewicz,
  • Piotr Ślósarz,
  • Leszek Nogowski and
  • Paweł A. Kołodziejski

17 April 2021

The increasing prevalence of overweight and obesity and the rising awareness of their negative consequences are forcing researchers to take a new view of nutrition and its consequences for the metabolism of whole organisms as well as the metabolism o...

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Biology - ISSN 2079-7737