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Antibiotics, Volume 13, Issue 2

February 2024 - 86 articles

Cover Story: Staphylococcal Chromosome Cassette mec (SCCmec) is a mobile genetic element encoding methicillin resistance genes found in many pathogenic staphylococci, including the canine pathogen Staphylococcus pseudintermedius. We characterized SCCmec elements from four dominant S. pseudintermedius sequence types (STs) from the United States. All STs harbored unique SCCmec types, except STs 84 (Agr group I) and 64 (Agr group II), which shared the basic SCCmecNA45 backbone. Notably, SCCmec type III(KM1381) of ST71 (Agr group IIII) exclusively harbored the psm-mec locus, encoding both a regulatory RNA and a toxin. Its gene product, PSM-mec, was detected in culture filtrates. Our data contribute to our understanding of the global spread of methicillin-resistant S. pseudintermedius and which additional virulence factors may drive its pathogenesis. View this paper
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Articles (86)

  • Article
  • Open Access
11 Citations
4,572 Views
19 Pages

Potential of an Isolated Bacteriophage to Inactivate Klebsiella pneumoniae: Preliminary Studies to Control Urinary Tract Infections

  • João Duarte,
  • Carolina Máximo,
  • Pedro Costa,
  • Vanessa Oliveira,
  • Newton C. M. Gomes,
  • Jesús L. Romalde,
  • Carla Pereira and
  • Adelaide Almeida

19 February 2024

Urinary tract infections (UTIs) caused by resistant Klebsiella pneumoniae can lead to severe clinical complications and even death. An alternative treatment option for infected patients is using bacteriophages. In the present study, we isolated phage...

  • Article
  • Open Access
9 Citations
3,686 Views
17 Pages

Emergence of Carbapenemase Genes in Gram-Negative Bacteria Isolated from the Wastewater Treatment Plant in A Coruña, Spain

  • Mohammed Nasser-Ali,
  • Pablo Aja-Macaya,
  • Kelly Conde-Pérez,
  • Noelia Trigo-Tasende,
  • Soraya Rumbo-Feal,
  • Ana Fernández-González,
  • Germán Bou,
  • Margarita Poza and
  • Juan A. Vallejo

17 February 2024

Wastewater treatment plants (WWTPs) are recognized as important niches of antibiotic-resistant bacteria that can be easily spread to the environment. In this study, we collected wastewater samples from the WWTP of A Coruña (NW Spain) from Apri...

  • Article
  • Open Access
9 Citations
4,052 Views
25 Pages

Synthesis of 3-((4-Hydroxyphenyl)amino)propanoic Acid Derivatives as Promising Scaffolds for the Development of Antimicrobial Candidates Targeting Multidrug-Resistant Bacterial and Fungal Pathogens

  • Povilas Kavaliauskas,
  • Birutė Grybaitė,
  • Birutė Sapijanskaitė-Banevič,
  • Rita Vaickelionienė,
  • Vidmantas Petraitis,
  • Rūta Petraitienė,
  • Ethan Naing,
  • Andrew Garcia,
  • Ramunė Grigalevičiūtė and
  • Vytautas Mickevičius

17 February 2024

Infections caused by multidrug-resistant bacterial and fungal pathogens represent a significant global health concern, contributing to increased morbidity and mortality rates. Therefore, it is crucial to develop novel compounds targeting drug-resista...

  • Article
  • Open Access
7 Citations
4,592 Views
23 Pages

Bacterial Community- and Hospital-Acquired Pneumonia in Patients with Critical COVID-19—A Prospective Monocentric Cohort Study

  • Lenka Doubravská,
  • Miroslava Htoutou Sedláková,
  • Kateřina Fišerová,
  • Olga Klementová,
  • Radovan Turek,
  • Kateřina Langová and
  • Milan Kolář

16 February 2024

The impact of bacterial pneumonia on patients with COVID-19 infection remains unclear. This prospective observational monocentric cohort study aims to determine the incidence of bacterial community- and hospital-acquired pneumonia (CAP and HAP) and i...

  • Article
  • Open Access
15 Citations
3,921 Views
21 Pages

16 February 2024

Carbapenem-resistant Pseudomonas aeruginosa (P. aeruginosa) strains have become a global threat due to their remarkable capability to survive and disseminate successfully by the acquisition of resistance genes. As a result, the treatment strategies h...

  • Article
  • Open Access
5 Citations
2,703 Views
18 Pages

16 February 2024

In this study, we developed a method for the expression of the antimicrobial peptide SE-33-A2P in E. coli bacterial cells. The SE-33-A2P peptide consists of A2P and SE-33 peptides and is a retro analog of cathelicidin possessing antimicrobial activit...

  • Article
  • Open Access
6 Citations
2,794 Views
9 Pages

Antibiotic-Prescribing Habits in Dentistry: A Questionnaire-Based Study

  • Luca Sbricoli,
  • Giulio Grisolia,
  • Edoardo Stellini,
  • Christian Bacci,
  • Marco Annunziata and
  • Eriberto Bressan

16 February 2024

The problem of antibiotic resistance is becoming increasingly serious worldwide due to uncontrolled prescription. Dentists are among the groups that prescribe the most antibiotics, often to delay urgent treatment. The purpose of the present study is...

  • Article
  • Open Access
2 Citations
2,003 Views
11 Pages

Lack of Association between Antimicrobial Consumption and Antimicrobial Resistance in a HIV Preexposure Prophylaxis Population: A Cross-Sectional Study

  • Thibaut Vanbaelen,
  • Jolein Laumen,
  • Christophe Van Dijck,
  • Tessa De Block,
  • Sheeba Santhini Manoharan-Basil and
  • Chris Kenyon

16 February 2024

Background: In antibiotic naïve populations, there is a strong association between the use of an antimicrobial and resistance to this antimicrobial. Less evidence is available as to whether this relationship is weakened in populations highly exp...

  • Article
  • Open Access
10 Citations
3,300 Views
13 Pages

Catastrophic Streptococcus pyogenes Disease: A Personalized Approach Based on Phenotypes and Treatable Traits

  • Juan Carlos Ruiz-Rodríguez,
  • Luis Chiscano-Camón,
  • Carolina Maldonado,
  • Adolf Ruiz-Sanmartin,
  • Laura Martin,
  • Ivan Bajaña,
  • Juliana Bastidas,
  • Rocio Lopez-Martinez,
  • Clara Franco-Jarava and
  • Juan José González-López
  • + 5 authors

15 February 2024

Streptococcal toxic shock syndrome (STTS) is a critical medical emergency marked by high morbidity and mortality, necessitating swift awareness, targeted treatment, and early source control due to its rapid symptom manifestation. This report focuses...

  • Article
  • Open Access
2,238 Views
24 Pages

Impact of Anti-Mycotic Drugs on the Osteogenic Response of Bone Marrow Mesenchymal Stem Cells In Vitro

  • Tim Niklas Bewersdorf,
  • Jakob Hofmann,
  • Sebastian Findeisen,
  • Christian Schamberger,
  • Thomas Lingner,
  • Ulrike Sommer,
  • Gerhard Schmidmaier and
  • Tobias Grossner

15 February 2024

The treatment of fungal bone infections and infected non-unions is a huge challenge in modern trauma and orthopedics, which normally contain the local and systemic administration of anti-fungal drugs. Although frequently used, little is known about t...

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Antibiotics - ISSN 2079-6382Creative Common CC BY license