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Antibiotics, Volume 13, Issue 1

January 2024 - 109 articles

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Cover Story: Colistin is used as a last-resort antibiotic against highly resistant Gram-negative bacteria (GNB). Rising rates of colistin resistance, however, may limit future use of this agent. The anthelmintic drug niclosamide has been shown to enhance colistin activity in combination therapy, but a detailed structure–activity relationship (SAR) for niclosamide against GNB has yet to be studied. A series of niclosamide analogs were synthesized to perform an SAR, leading to the discovery of a lead compound that displayed comparable colistin-potentiating activity to niclosamide with reduced cytotoxicity. Overall, this work provides important insights into synthetic strategies for the future development of novel niclosamide derivatives and demonstrates that toxicity to mammalian cells can be reduced while maintaining colistin potentiation. View this paper

Articles (109)

  • Article
  • Open Access
6 Citations
2,787 Views
14 Pages

The In Vitro Antibacterial Activity of Argirium SUNc against Most Common Pathogenic and Spoilage Food Bacteria

  • Andrea Mancusi,
  • Marica Egidio,
  • Raffaele Marrone,
  • Luca Scotti,
  • Domenico Paludi,
  • Irene Dini and
  • Yolande Thérèse Rose Proroga

Foodborne diseases are one of the main issues for human health, and antibacterial packaging plays a major role in food security assurance. Silver ultra nanoparticles (Argirium SUNc) are antimicrobial agents that have a wide spectrum of action, includ...

  • Article
  • Open Access
1 Citations
4,218 Views
15 Pages

Antimicrobial Properties Related to Anti-Acne and Deodorant Efficacy of Hedychium coronarium J. Koenig Extracts from Pulsed Electric Field Extraction

  • Manasanan Mitchaleaw,
  • Saranya Juntrapirom,
  • Anurak Bunrod,
  • Watchara Kanjanakawinkul,
  • Artit Yawootti,
  • Wannaree Charoensup,
  • Sasithorn Sirilun and
  • Wantida Chaiyana

This study investigated the potential of pulsed electric field (PEF) extraction in enhancing the antimicrobial properties related to anti-acne and deodorant properties of Hedychium coronarium extract. The dried leaf and rhizome of H. coronarium were...

  • Article
  • Open Access
5 Citations
2,947 Views
13 Pages

Source Attribution of Antibiotic Resistance Genes in Estuarine Aquaculture: A Machine Learning Approach

  • Helena Sofia Salgueiro,
  • Ana Cristina Ferreira,
  • Ana Sofia Ribeiro Duarte and
  • Ana Botelho

Aquaculture located in urban river estuaries, where other anthropogenic activities may occur, has an impact on and may be affected by the environment where they are inserted, namely by the exchange of antimicrobial resistance genes. The latter may ul...

  • Article
  • Open Access
5 Citations
2,762 Views
15 Pages

Antibiofilm Properties and Demineralization Suppression in Early Enamel Lesions Using Dental Coating Materials

  • Niraya Kornsombut,
  • Shoji Takenaka,
  • Maki Sotozono,
  • Ryoko Nagata,
  • Takako Ida,
  • Jutharat Manuschai,
  • Rui Saito,
  • Ryouhei Takahashi and
  • Yuichiro Noiri

This study aimed to investigate the effects of dental coating materials on Streptococcus mutans biofilm formation. The test materials were PRG Barrier Coat (PRG), BioCoat Ca (BioC), and FluorDental Jelly (FluorJ). Bovine enamel specimens were deminer...

  • Article
  • Open Access
1 Citations
3,299 Views
14 Pages

Streptococcus pneumoniae Infection in Patients with Asplenia: A Spanish Perspective over a 25-Year Period

  • Enrique Gea-Izquierdo,
  • Gil Rodríguez-Caravaca,
  • Ruth Gil-Prieto,
  • Valentín Hernández-Barrera and
  • Ángel Gil-de-Miguel

Anatomical or functional asplenia constitutes a risk factor for Streptococcus pneumoniae (SP) infection, being more frequent in children and the elderly and in people with multiple comorbidities. We aimed to describe the impact of invasive pneumococc...

  • Article
  • Open Access
3 Citations
2,490 Views
12 Pages

Associations between Isolation Source, Clonal Composition, and Antibiotic Resistance Genes in Escherichia coli Collected in Washington State, USA

  • Mary Jewell,
  • Erica R. Fuhrmeister,
  • Marilyn C. Roberts,
  • Scott J. Weissman,
  • Peter M. Rabinowitz and
  • Stephen E. Hawes

Antimicrobial resistance (AMR) is a global health problem stemming from the use of antibiotics in humans, animals, and the environment. This study used whole-genome sequencing (WGS) of E. coli to explore patterns of AMR across sectors in Washington S...

  • Article
  • Open Access
8 Citations
3,387 Views
11 Pages

Hospital Antibiotic Consumption before and during the COVID-19 Pandemic in Hungary

  • Roxána Ruzsa,
  • Ria Benkő,
  • Helga Hambalek,
  • Erika Papfalvi,
  • Dezső Csupor,
  • Róbert Nacsa,
  • Márta Csatordai,
  • Gyöngyvér Soós,
  • Edit Hajdú and
  • Mária Matuz

The aim of this study was to assess antibiotic use in the Hungarian hospital care sector during and before the pandemic. Aggregated systemic antibiotic (ATC: J01) utilisation data were obtained for the 2010–2021 period. Classifications and calc...

  • Article
  • Open Access
11 Citations
4,218 Views
12 Pages

Linezolid Resistance Genes and Mutations among Linezolid-Susceptible Enterococcus spp.—A Loose Cannon?

  • Jennifer K. Bender,
  • Carola Fleige,
  • Finn Funk,
  • Clara Moretó-Castellsagué,
  • Martin A. Fischer and
  • Guido Werner

The National Reference Centre for Enterococci receives an increasing number of linezolid-resistant Enterococcus isolates. Linezolid (LIN) resistance is mediated by G2576T 23S rDNA gene mutations and/or acquisition of resistance genes (cfr, optrA, pox...

  • Review
  • Open Access
16 Citations
11,653 Views
16 Pages

Surgical Antibiotic Prophylaxis: A Proposal for a Global Evidence-Based Bundle

  • Massimo Sartelli,
  • Federico Coccolini,
  • Francesco M. Labricciosa,
  • AbdelKarim. H. Al Omari,
  • Lovenish Bains,
  • Oussama Baraket,
  • Marco Catarci,
  • Yunfeng Cui,
  • Alberto R. Ferreres and
  • George Gkiokas
  • + 20 authors

In the multimodal strategy context, to implement healthcare-associated infection prevention, bundles are one of the most commonly used methods to adapt guidelines in the local context and transfer best practices into routine clinical care. One of the...

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