Dear Colleagues,

Antimicrobial resistance is still a serious and growing problem in the treatment of severe infections. There are two main approaches to tackle this challenge: the development of novel substances which can bypass the resistance mechanisms, but also the continuous development of strategies to increase the adequate prescription of currently available antibiotics where they are needed. The last approach, i.e., antimicrobial stewardship strategies, is already well established in many countries and usually consists of a bundle of recommendations in order to improve the prescription practice and thus slow down the development of resistance. Among the recommendations communicated within antimicrobial stewardship programs or guidelines, the publication of local treatment guidelines and an antibiotics house list with concrete dosage recommendations are recommended for each hospital. This sounds like a clear and easy task but nevertheless requires teamwork among experts in practical reality and very often thorough consideration of advantages or disadvantages of different recommendations.

This Special Issue is meant to bring some new answers to the following questions: 1. Is there a rationale for the selection of antibiotics in special situations such as treatment of severe infections with abscess formation? 2. Should we use special dosage recommendations in distinct clinical circumstances that lead to altered antibiotic concentrations at the site of infection (e.g., special dosing recommendations for patients with altered kidney or liver function, renal replacement therapy or obesity)?

Invited are papers of any type (case reports, original articles describing the setup of a new local guideline, review articles) with a clear rationale and clear message for the colleagues.

Dr. Andreas A. Von Ameln-Mayerhofer
Guest Editor

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