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Antibiotics, Volume 12, Issue 8

August 2023 - 118 articles

Cover Story: Amphiphilic tobramycins are an emerging class of antibiotic potentiators against Gram-negative bacteria, including Pseudomonas aeruginosa. To study how the antibiotic-potentiating effect of amphiphilic tobramycins is affected by the presence of intermolecular iron chelators, we conjugated the FDA-approved iron chelator deferiprone (DEF) to tobramycin (TOB). While TOB-DEF conjugates were inactive against P. aeruginosa, all TOB-DEF conjugates strongly synergized with outer-membrane-impermeable antibiotics. The optimized conjugate displayed selective and synergistic potentiation of tetracycline antibiotics against multidrug-resistant P. aeruginosa isolates. However, the tetracycline-potentiating effect of the conjugate is independent of the Fe3+-complexing properties and is the result of enhanced outer membrane permeability. View this paper
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Articles (118)

  • Article
  • Open Access
7 Citations
3,152 Views
14 Pages

Prevalence and Antimicrobial Resistance Profile of Diarrheagenic Escherichia coli from Fomites in Rural Households in South Africa

  • Phathutshedzo Rakhalaru,
  • Lutendo Munzhedzi,
  • Akebe Luther King Abia,
  • Jean Pierre Kabue,
  • Natasha Potgieter and
  • Afsatou Ndama Traore

Diarrheagenic Escherichia coli (DEC) pathotypes are the leading cause of mortality and morbidity in South Asia and sub-Saharan Africa. Daily interaction between people contributes to the spreading of Escherichia coli (E. coli), and fomites are a comm...

  • Article
  • Open Access
2 Citations
2,309 Views
20 Pages

Rationally Designed Pyrimidine Compounds: Promising Novel Antibiotics for the Treatment of Staphylococcus aureus-Associated Bovine Mastitis

  • Guillaume Millette,
  • Evelyne Lacasse,
  • Renaud Binette,
  • Véronique Belley,
  • Louis-Philippe Chaumont,
  • Céline Ster,
  • Francis Beaudry,
  • Kumaraswamy Boyapelly,
  • Pierre-Luc Boudreault and
  • François Malouin

Staphylococcus aureus is one of the major pathogens causing bovine mastitis, and antibiotic treatment is most often inefficient due to its virulence and antibiotic-resistance attributes. The development of new antibiotics for veterinary use should ac...

  • Article
  • Open Access
3 Citations
3,210 Views
15 Pages

Hospital Pharmacists’ Viewpoint on Quality Use of Antibiotics and Resistance: A Qualitative Exploration from a Tertiary Care Hospital of Quetta City, Pakistan

  • Maryam Farooqui,
  • Zaffar Iqbal,
  • Abdul Sadiq,
  • Abdul Raziq,
  • Mohammed Salem Alshammari,
  • Qaiser Iqbal,
  • Sajjad Haider and
  • Fahad Saleem

Suboptimal antibiotics use and the development of antibiotic resistance is a universal calamity. The theoretical model of therapeutic efficacy correlates quality use of antibiotics with healthcare practitioners’ understanding of antibiotic use...

  • Review
  • Open Access
15 Citations
4,010 Views
13 Pages

Antimicrobial Stewardship Programs in Latin America and the Caribbean: A Story of Perseverance, Challenges, and Goals

  • Natalia Restrepo-Arbeláez,
  • Juan Carlos Garcia-Betancur,
  • Christian Jose Pallares and
  • María Virginia Villegas

Antimicrobial resistance is one of the major global health threats. Antimicrobial stewardship (AMS) has been set as a priority within international action plans to combat this issue. The region of Latin America and the Caribbean are recognized for th...

  • Article
  • Open Access
1,810 Views
17 Pages

Molecular Cloning, Expression Analyses, and Physiological Roles of Cathelicidins in the Bursa of Fabricius of the Japanese Quail, Coturnix japonica

  • Takumi Ikeda,
  • Hirotada Kondo,
  • Daiki Nunomura,
  • Genki Sato,
  • Machi Ito,
  • Nanako Yamanaka,
  • Shawichi Iwamuro,
  • Itaru Hasunuma,
  • Sakae Kikuyama and
  • Tetsuya Kobayashi

Antimicrobial peptides (AMPs) act directly on pathogens and maintain the anti-inflammatory effects and activation of immunocompetent cells. Therefore, the activation of the immune system in poultry via the elevation of endogenous AMPs has been attemp...

  • Review
  • Open Access
5 Citations
4,256 Views
27 Pages

Sensing of Antibiotic–Bacteria Interactions

  • Anna A. Baranova,
  • Anton P. Tyurin,
  • Vladimir A. Korshun and
  • Vera A. Alferova

Sensing of antibiotic–bacteria interactions is an important area of research that has gained significant attention in recent years. Antibiotic resistance is a major public health concern, and it is essential to develop new strategies for detect...

  • Article
  • Open Access
4 Citations
2,457 Views
9 Pages

The aim of this study was to determine the antibiotic resistance of E. rhusiopathiae when isolated from clinical outbreaks of erysipelas in geese to antimicrobials commonly used in poultry production. All isolates were susceptible to amoxicillin alon...

  • Systematic Review
  • Open Access
12 Citations
6,210 Views
23 Pages

Physicochemical Characteristics of Antimicrobials and Practical Recommendations for Intravenous Administration: A Systematic Review

  • Fabio Borgonovo,
  • Massimiliano Quici,
  • Antonio Gidaro,
  • Davide Giustivi,
  • Dario Cattaneo,
  • Cristina Gervasoni,
  • Maria Calloni,
  • Elena Martini,
  • Leyla La Cava and
  • Spinello Antinori
  • + 3 authors

Most antimicrobial drugs need an intravenous (IV) administration to achieve maximum efficacy against target pathogens. IV administration is related to complications, such as tissue infiltration and thrombo-phlebitis. This systematic review aims to pr...

  • Article
  • Open Access
2 Citations
2,227 Views
17 Pages

Ceftobiprole Medocaril Is an Effective Post-Exposure Treatment in the Fischer 344 Rat Model of Pneumonic Tularemia

  • Mark M. Hahn,
  • Cheryl A. Triplett,
  • Michael S. Anderson,
  • Jennifer I. Smart,
  • Karine Litherland,
  • Stephen Keech,
  • Franziska von Siebenthal,
  • Mark Jones,
  • Andrew J. Phipps and
  • Lisa N. Henning

Francisella tularensis subspecies tularensis is a category-A biothreat agent that can cause lethal tularemia. Ceftobiprole medocaril is being explored as a medical countermeasure for the treatment of pneumonic tularemia. The efficacy of ceftobiprole...

  • Article
  • Open Access
2,144 Views
15 Pages

A Study on the Epidemiological-Molecular Role of Staphylococcus aureus Strains in the Development of Ventilator-Associated Pneumonia in a Tertiary Hospital in Brazil

  • Mariana Fávero Bonesso,
  • Carlos Magno Castelo Branco Fortaleza,
  • Ricardo de Souza Cavalcante,
  • Moises Teixeira Sobrinho,
  • Carlos Fernando Ronchi,
  • Lígia Maria Abraão,
  • Hwang-Soo Joo,
  • Michael Otto and
  • Maria de Lourdes Ribeiro de Souza da Cunha

This study aimed to explore the molecular epidemiology of Staphylococcus aureus isolated from patients on mechanical ventilation and the participation of virulence factors in the development of ventilator-associated pneumonia (VAP). A prospective coh...

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Antibiotics - ISSN 2079-6382