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Journal of Clinical Medicine, Volume 8, Issue 2

2019 February - 153 articles

Cover Story: Chemoresistance is among the most formidable clinical challenges in oncology. One key mediator of chemoresistance is through phenotypic plasticity. Phenotypic plasticity is the rewiring of gene expression circuitry to convert between phenotypes. Phenotypic plasticity promotes chemoresistance, engages pro-metastatic pathways, and serves as a prognostic marker for poorer clinical outcomes across multiple cancers. While phenotypic plasticity has been well-studied there is still much to be learned about mechanisms through which plasticity contributes to chemoresistance. To better understand the connections between plasticity, gene expression rewiring, and chemoresistance Xu et al. used an integrated evolutionary, systems biology, and experimental approach. Read more to learn about the relationships uncovered between plasticity, metabolic reprogramming, autophagy, and chemoresistance. View this paper
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Articles (153)

  • Feature Paper
  • Review
  • Open Access
91 Citations
16,735 Views
19 Pages

25 February 2019

The prevalence of implant biological complications has grown enormously over the last decade, in concordance with the impact of biofilm and its byproducts upon disease development. Deleterious habits and systemic conditions have been regarded as risk...

  • Review
  • Open Access
45 Citations
7,576 Views
16 Pages

25 February 2019

Transcatheter aortic valve implantation (TAVI) has emerged as an important alternative to surgical aortic valve repair (SAVR) for patients with severe aortic stenosis. This rapidly advancing field has produced new-generation devices being delivered w...

  • Article
  • Open Access
28 Citations
5,701 Views
14 Pages

Genomic Variations in Susceptibility to Intracranial Aneurysm in the Korean Population

  • Eun Pyo Hong,
  • Bong Jun Kim,
  • Steve S. Cho,
  • Jin Seo Yang,
  • Hyuk Jai Choi,
  • Suk Hyung Kang and
  • Jin Pyeong Jeon

25 February 2019

Genome-wide association studies found genetic variations with modulatory effects for intracranial aneurysm (IA) formations in European and Japanese populations. We aimed to identify the susceptibility of single nucleotide polymorphisms (SNPs) to IA i...

  • Concept Paper
  • Open Access
15 Citations
5,557 Views
17 Pages

Dialysis Reimbursement: What Impact Do Different Models Have on Clinical Choices?

  • Giorgina Barbara Piccoli,
  • Gianfranca Cabiddu,
  • Conrad Breuer,
  • Christelle Jadeau,
  • Angelo Testa and
  • Giuliano Brunori

25 February 2019

Allowing patients to live for decades without the function of a vital organ is a medical miracle, but one that is not without cost both in terms of morbidity and quality of life and in economic terms. Renal replacement therapy (RRT) consumes between...

  • Article
  • Open Access
9 Citations
3,294 Views
10 Pages

Differences in Sexually Transmitted Infections between the Precrisis Period (2000–2007) and the Crisis Period (2008–2014) in Granada, Spain

  • María Ángeles Pérez-Morente,
  • María Teresa Sánchez-Ocón,
  • Encarnación Martínez-García,
  • Adelina Martín-Salvador,
  • César Hueso-Montoro and
  • Inmaculada García-García

25 February 2019

Objective: To analyze the difference in the prevalence of sexually transmitted infections (STIs) between two time periods (2000–2007 and 2008–2014, with the latter period characterized by the economic crisis), as well as determine differe...

  • Review
  • Open Access
55 Citations
10,177 Views
42 Pages

Medication in AN: A Multidisciplinary Overview of Meta-Analyses and Systematic Reviews

  • Corinne Blanchet,
  • Sébastien Guillaume,
  • Flora Bat-Pitault,
  • Marie-Emilie Carles,
  • Julia Clarke,
  • Vincent Dodin,
  • Philibert Duriez,
  • Priscille Gerardin,
  • Mouna Hanachi-Guidoum and
  • Nathalie Godart
  • + 4 authors

25 February 2019

Drugs are widely prescribed for anorexia nervosa in the nutritional, somatic, and psychiatric fields. There is no systematic overview in the literature, which simultaneously covers all these types of medication. The main aims of this paper are (1) to...

  • Article
  • Open Access
28 Citations
4,196 Views
12 Pages

The Oncogenic Activity of miR-29b-1-5p Induces the Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma

  • Miyako Kurihara-Shimomura,
  • Tomonori Sasahira,
  • Hiroyuki Shimomura,
  • Chie Nakashima and
  • Tadaaki Kirita

24 February 2019

Background: The relationship between miR-29b-1-5p and c-Met proto-oncogene in oral squamous cell carcinoma (OSCC) remains to be investigated. This study aimed to reveal the role of miR-29b-1-5p in the pathogenesis of OSCC using molecular and biologic...

  • Review
  • Open Access
38 Citations
7,285 Views
18 Pages

A Systematic Review of the Short-Term Health Effects of Air Pollution in Persons Living with Coronary Heart Disease

  • Darren E. R. Warburton,
  • Shannon S. D. Bredin,
  • Erin M. Shellington,
  • Christie Cole,
  • Amanda de Faye,
  • Jennifer Harris,
  • David D. Kim and
  • Alan Abelsohn

24 February 2019

Persons living with chronic medical conditions (such as coronary artery disease (CAD)) are thought to be at increased risk when exposed to air pollution. This systematic review critically evaluated the short-term health effects of air pollution in pe...

  • Article
  • Open Access
20 Citations
4,801 Views
22 Pages

23 February 2019

The autoclaving process is one of the sterilization procedures of implantable devices. Therefore, it is important to assess the impact of hot steam at high pressure on the morphology, structure, and properties of implants modified by nanocomposite co...

  • Review
  • Open Access
17 Citations
6,164 Views
13 Pages

22 February 2019

Concerns about the effects of propranolol on the central nervous system (CNS) in the infantile hemangioma (IH) population have been raised. We conducted a meta-analysis of the CNS and sleep-related effects of oral propranolol in IH patients. PubMed,...

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J. Clin. Med. - ISSN 2077-0383