Table of Contents
J. Clin. Med., Volume 8, Issue 2 (February 2019)
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Cover Story (view full-size image) Chemoresistance is among the most formidable clinical challenges in oncology. One key mediator of [...] Read more. Chemoresistance is among the most formidable clinical challenges in oncology. One key mediator of chemoresistance is through phenotypic plasticity. Phenotypic plasticity is the rewiring of gene expression circuitry to convert between phenotypes. Phenotypic plasticity promotes chemoresistance, engages pro-metastatic pathways, and serves as a prognostic marker for poorer clinical outcomes across multiple cancers. While phenotypic plasticity has been well-studied there is still much to be learned about mechanisms through which plasticity contributes to chemoresistance. To better understand the connections between plasticity, gene expression rewiring, and chemoresistance Xu et al. used an integrated evolutionary, systems biology, and experimental approach. Read more to learn about the relationships uncovered between plasticity, metabolic reprogramming, autophagy, and chemoresistance. View this paper