Table of Contents
J. Clin. Med., Volume 8, Issue 3 (March 2019) – 135 articles
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
- You may sign up for e-mail alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story (view full-size image) Androgen/AR signaling negatively regulates CCL2 secretion. The CCL2-CCR2 axis induces prostate [...] Read more. Androgen/AR signaling negatively regulates CCL2 secretion. The CCL2-CCR2 axis induces prostate cancer cell migration and chemoresistance to taxanes. The CCL22-CCR4 axis is located downstream of the CCL2-CCR2 axis and further increases the migratory capacity of prostate cancer cells. CCL5 activity occurs upstream of androgen/AR signaling and increases the migratory capacity of prostate cancer cells via inhibition of androgen/AR signaling. Androgen/AR signaling also indirectly regulates CCR7 expression in prostate cancer cells. CCR7 binds CCL21 from fibroblastic reticular cells in lymph node, resulting in increased migratory capacity of prostate cancer cells. Androgen/AR signaling increases prostate cancer cell proliferation, while simultaneously inhibiting migration via suppression of CCLs-CCRs axes. View this paper