Table of Contents
J. Clin. Med., Volume 8, Issue 3 (March 2019)
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Cover Story (view full-size image) Androgen/AR signaling negatively regulates CCL2 secretion. The CCL2-CCR2 axis induces prostate [...] Read more. Androgen/AR signaling negatively regulates CCL2 secretion. The CCL2-CCR2 axis induces prostate cancer cell migration and chemoresistance to taxanes. The CCL22-CCR4 axis is located downstream of the CCL2-CCR2 axis and further increases the migratory capacity of prostate cancer cells. CCL5 activity occurs upstream of androgen/AR signaling and increases the migratory capacity of prostate cancer cells via inhibition of androgen/AR signaling. Androgen/AR signaling also indirectly regulates CCR7 expression in prostate cancer cells. CCR7 binds CCL21 from fibroblastic reticular cells in lymph node, resulting in increased migratory capacity of prostate cancer cells. Androgen/AR signaling increases prostate cancer cell proliferation, while simultaneously inhibiting migration via suppression of CCLs-CCRs axes. View this paper