A Systematic Review of the Short-Term Health Effects of Air Pollution in Persons Living with Coronary Heart Disease

Persons living with chronic medical conditions (such as coronary artery disease (CAD)) are thought to be at increased risk when exposed to air pollution. This systematic review critically evaluated the short-term health effects of air pollution in persons living with CAD. Original research articles were retrieved systematically through searching electronic databases (e.g., Medical Literature Analysis and Retrieval System Online (MEDLINE)), cross-referencing, and the authors’ knowledge. From 2884 individual citations, 26 eligible articles were identified. The majority of the investigations (18 of 22 (82%)) revealed a negative relationship between air pollutants and cardiac function or overall health. Heart rate variability (HRV) was the primary cardiovascular outcome measure, with 10 out of 13 studies reporting at least one index of HRV being significantly affected by air pollutants. However, there was some inconsistency in the relationship between HRV and air pollutants, mediated (at least in part) by the confounding effects of beta-blocker medications. In conclusion, there is strong evidence that air pollution can have adverse effects on cardiovascular function in persons living with CAD. All persons living with CAD should be educated on how to monitor air quality, should recognize the potential risks of excessive exposure to air pollution, and be aware of strategies to mitigate these risks. Persons living with CAD should minimize their exposure to air pollution by limiting outdoor physical activity participation when the forecast air quality health index indicates increased air pollution (i.e., an increased risk).


Introduction
Air pollution has been associated with various health issues, including worsening of heart and pulmonary conditions and increased risk for asthma, heart attacks, stroke, and premature mortality [1][2][3].The World Health Organization estimates that ambient air pollution contributes to 6.7% of all deaths [4].In 2008, the Canadian Medical Association estimated that approximately 11,000 hospital admissions, 92,000 emergency department visits, and 21,000 deaths annually could be attributed to air pollution [5].
Although ambient air pollutant concentrations appear to be decreasing overall [12], the elderly, children, pregnant women, those living with chronic medical conditions, and those with weakened immune systems appear to be particularly vulnerable to air pollution exposure and require special precautions [6,[13][14][15][16].Specifically, in persons living with coronary artery disease (CAD), air pollution has been associated with various complications such as increased cardiovascular disease-related hospitalizations/readmissions and premature mortality [1,10].Several mechanisms have been associated with increased risk, including changes in blood viscosity, oxidative stress and inflammation, vascular dysfunction, and altered autonomic function (such as decreased heart rate variability (HRV)) [6,17].The majority of the research relates to the long-term effects of air pollution exposure; however, mounting research has demonstrated the short-term adverse effects of air pollution [7,9,[18][19][20][21][22][23][24].
Routine exercise and/or physical activity participation is key to the secondary prevention of CAD [25].However, it remains unclear when the benefits of physical activity might be outweighed by the short-term risks associated with exercising in a polluted environment.A clearer understanding of the short-term risks associated with air pollution will provide further insight for optimum exercise recommendations when considering ambient air pollution for this sub-population and help inform recommendations made by air quality indexes [11,26].
To our knowledge, no systematic review has outlined the short-term health effects of air pollution in persons living with CAD.Accordingly, the primary objective was to critically examine the current literature to determine the short-term health risks associated with air pollution in persons living with CAD.A further objective was to provide recommendations to mediate these risks in patients with CAD in the context of the standard of care for secondary prevention including whether alterations in physical activity behaviour are warranted based on air pollution levels.

Criteria for Considering Studies for this Review
A rigorous, systematic, and evidence-based approach was used to examine the evidence regarding the short-term health effects of air pollution in persons living with CAD.We adhered to the standards established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations [27].For inclusion, studies needed to define clearly the exposure of air pollution, provide documented patient history of CAD, and have a clearly articulated cardiovascular outcome measure.All original studies that evaluated the effects of occupational exposures or reported multiple conditions besides CAD without a sub-group analysis were excluded.

Search Strategy
Literature searches were conducted in the following electronic bibliographical databases (

Screening
Two reviewers independently screened titles and abstracts of citations to identify potential articles for inclusion and to remove duplicate citations [28].Full-text versions of relevant articles were obtained, and data was extracted with a common template.In the case of disagreement (5% of cases), a third reviewer was included in order to achieve a full (100%) consensus.Reasons for exclusion of articles after full-article screening were recorded [28,29].
Two reviewers independently evaluated the level, grade, and quality, with consensus achieved through discussion as required (Table 2).The quality of investigations was assessed with the Downs and Black scoring system [30] as modified previously [29].

Level 1
Randomized control trials (including within participants comparison with randomized conditions and crossover designs) without important limitations.

Level 2
Randomized control trials with important limitations Observational studies (non-randomized clinical trials or cohort studies) with overwhelming evidence

Level 3
Other observational studies (prospective cohort studies, case-control studies, case series)

Level 4
Inadequate or no data in population of interest Anecdotal evidence or clinical experience

Grade A
Strong recommendation (action can apply to most individuals in most circumstances)

Grade C
Consensus recommendation (alternative actions may be equally reasonable) • Unclear if benefits outweigh risks • Evidence at Level 3 or 4

Overview of Studies Selected
A total of 26 articles were included in the final systematic review (Tables 3 and 4, Figure 1) including seven laboratory investigations and 19 real-life setting investigations, nine of which examined adverse effects during exercise.Quality assessment of articles varied considerably, but generally produced medium-quality investigations, with scores ranging from 8 to 13 out of 15 (Mean = 9.7 ± 1.3).
During the laboratory trials, exposure to various air pollutants were evaluated for adverse effects including ST-segment depressions, angina, arterial carboxyhemoglobin levels, arrhythmias, measures of HRV, heart rate (HR), and blood pressure (BP) [31][32][33][34][35][36], central aortic pulse wave velocity and augmentation index [37].Two studies looked at ST-segment depression related to pollution exposures in lab [31,32], while four studies considered exposures in real-life settings [37][38][39][40].Adverse associations were found between traffic exposure with exercise and subsequent ST-segment depression with CO in patients with CAD and survivors of myocardial infarction (MI) [31,32].Ambient PM 1 [39], PM 2.5 [39,40], number counts of particles sized 0.1-1 µm [39], ultrafine particles sized 0.01-0.1 µm [38], black carbon [39], CO [38], diesel exhaust [32], and SO 2 [39] were also associated with increased ST depression in patients with CAD.One study additionally reported expedited development of exercise-induced angina as well as increased mean HR after exposure to freeway air [31], though another found no difference in HR during exposures to filtered air and diesel exhaust [32].Lastly, a recent study found that the vascular benefits associated with exercise were attenuated in a polluted street compared to a non-polluted urban park in adults with ischemic heart disease [37].

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Exposure to NO 2 (400 ppb) for 1 h produced no significant changes in heart rate, BP, or HRV measures in study patients.Hood delivery system used to ensure other pollutants unlikely the cause of results.

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No patients in this trial used beta-blockers, though other medications used heterogeneously.

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HRV changes were not associated with either PM 1.0-2.5 or PM 2.5-10 .

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No patients in this trial used beta-blockers.

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Patients with CAD not taking beta-blockers had significantly decreased SDNN after exposure to higher levels of CO.This effect was not seen after exposure to PM 2.5 .

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Personal exposure to elemental carbon and NO 2 24 h prior to HRV measurement was significantly associated to decreased r-MSSD, PNN50, HF and HF/LF ratio.

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Personal and ambient exposure to PM 2.5 , and exposure to elemental carbon and NO 2 was not significantly associated with changes in HRV.

•
Beta-blocker use accounted for in models, but effects not described (small sample size).• Elderly CAD patients had significant increases in their rMSSD after high exposure to CO (4-6 ppm.).

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No other significant changes after CO exposure in HRV measurements were seen.: the mass concentration of fine particles with aerodynamic diameters of <2.5 µm; PM 0.3-1.0: particulate matter with aerodynamic diameters between 0.3 and 1.0 µm; PNC: particle number concentration; PNN50: percent of absolute differences between successive normal R-R intervals that exceed 50 ms; QRS complex: ventricular depolarization on electrocardiogram (ECG); QTc: corrected QT interval; rMSSD: square root of the mean of the sum of squares of successive differences between adjacent N-N intervals; SDNN: standard deviation of normal-to-normal (N-N) intervals; SDANN: standard deviation of average normal-to-normal (N-N) intervals within successive 5-min blocks; ST segment: portion of ECG from ventricular depolarization to repolarization; TP: total power; TRII: triangular index; UFP: ultrafine particle; VLF: very low frequency domain (0.0033 to 0.04.H).Bold font indicates air pollution exposures in each study.SD: standard deviation.Note: Bolded text is used to highlight the air pollutant exposure in each study.

Blood Markers and Heart Rhythm
Two laboratory studies reported significantly increased arterial carboxyhemoglobin and expired air CO levels after exposure to heavy traffic exhaust or CO [31,33].Ventricular arrhythmias were studied in conjunction 4% and 6% mean carboxyhemoglobin levels [33].These studies revealed that exposure to 200 ppm of CO induced 6% carboxyhemoglobin levels in CAD patients, which was associated with increased number and complexity of ventricular arrhythmias.
One retrospective study analyzed electrocardiograms (ECGs) from a database of patients with coronary artery disease and correlated ECG abnormalities with centrally monitored PM 2.5 and ozone for up to four days prior to ECG recordings; it was found that increased air pollutants (ozone and PM 2.5 ) were associated with lengthened PR, QRS, and QT intervals and increased heart rate resulting in ECG abnormalities for up to seven days [44].

Vascular Measures
Blood pressure and HR were examined as secondary measures in five investigations [31,32,34,35,37].Results from two studies conflicted with others, finding systolic BP and HR is negatively associated with heavy traffic in patients living with CAD whereas the other studies showed no relationship [31][32][33]35].A recent study found an adverse association between walking in a polluted area (Oxford Street, London, UK) compared to a non-polluted area (Hyde Park, London, UK), whereby the polluted area (black carbon, PM 2.5 , PM 10 , and ultrafine particles) impaired benefits on pulse wave velocity and augmentation index following an acute bout of exercise in adults with ischemic heart disease [37].Lastly, a study found that decreased large artery elasticity index was associated with increasing ozone in adults with coronary artery disease [41].

Heart Rate Variability Outcomes
Three laboratory studies investigated HRV after exposure to NO 2 , diesel exhaust, SO 2 , or carbon particles [34][35][36].None of these studies found an association between HRV indices and the various pollutants in patients with stable angina or CAD.Twelve real-life studies identified reduced HRV measures associated with exposures to PM 10 [38], PM 10-2.5 [38], PM 2.5 [19,24,45], PM 0.3-1.0[7], SO 2 [34], NO 2 [20,35], CO [18,21,24,45], elemental carbon [20], and black carbon [45].Reduced standard deviation of normal-to-normal (N-N) intervals (SDNN) was observed in a number of studies, associated with PM of different sizes as well as CO, and black carbon exposure [7,18,19,38,45].The length of time between the exposure and observed adverse HRV effects varied greatly from a short lag period of 2 h or less for black carbon [45], to 2-and 3-day lag periods for PM 2.5 [19].A decrease in the root mean square of successive differences between N-N intervals (rMSSD) was frequently found among HRV results.Multiple air pollutants (PM 2.5 , PM 0.3-1.0 , NO 2 , CO, black carbon, and elemental carbon) were found to reduce rMSSD in the CAD population, over timelines that varied in effect from 30 min to 24 h [7,20,21,45].Decreases in the high frequency (HF) index of HRV were frequently explored in these investigations, with PM 2.5 being associated with these reductions at time scales extending from 30 min through 5 days [19,24,45].Reduced HF was also associated with increases in elemental carbon [20], black carbon [45], and NO 2 [20] in individual study examples.Participants with CAD in a cardiac rehabilitation program showed an association between decreased rMSSD and accumulation mode particles (AMP; diameter 100-1000 nm) in a 6-24 h lag period, and non-significant decreases in rMSSD were associated with ultrafine particles and PM 2.5 prior to exercise.In addition, increased systolic blood pressure (0.84 mmHg) was significantly associated with ultrafine particles, AMP, and PM 2.5 for 0-24 h lag periods in the pre-exercise period; no significant associations were found in SDNN or mean N-N and no significant associations were found during the exercise sessions in HRV [42].
Other indices of HRV explored in single studies only, and in some cases the HRV indices are controversial in interpretation.Importantly, a few studies mentioned sub-analyses that demonstrated differences in HRV indices when comparing sub-groups that used different medications such as beta-blockers, and in a few cases the study included a majority of patients taking beta-blocking agents [24,[32][33][34]36,45] without providing a specific sub-analysis.In some papers, beta-blocking agents appeared to attenuate the adverse effects of air pollution exposure to patients [19,38].This aligned well with papers stating patients taking beta-blockers did not share the same associations with decreased HRV indices and increased air pollutants [18].Other commonly used medications such as calcium channel blockers or statins were frequently mentioned in the descriptive statistics; however, often no sub-analyses were provided to further explore the possibility of effect modification, in part due to insufficient power for proper analysis.One study did disclose that patients with diabetes experienced more substantial reductions in rMSSD compared to participants without diabetes [23].

Morbidity and Mortality Outcomes
In real-life setting studies of CAD patients, a single study identified that daily non-trauma mortality was increased when particle number concentration and PM 10 averages over 2 days were increased [6].Averaging times of 5 and 15 days for CO and NO 2 were associated with mortality as well [6]; however, this was the only study that considered mortality in patients with confirmed CAD.Another study revealed that short-term ozone exposure (within 1-2 days) was related to acute myocardial infarction in middle-aged adults without heart disease [43].However, no associations were found between acute myocardial infarction in participants with a history of CAD after exposure to elevated levels of ozone, NO 2 , or SO 2 .No other environmental studies identified mortality as an endpoint in patients previously diagnosed with CAD; however, one group identified increased same-day readmissions for MI survivors when concentrations of many pollutants were elevated [10].

Discussion
While the negative long-term health effects of air pollution are well established (i.e., increased morbidity and premature mortality), it is unclear whether individuals living with CAD are more susceptible to short-term adverse cardiovascular events than the general population.To the best of our knowledge, this systematic review is the first to evaluate this subject.Inconsistent findings regarding the effects of various air pollutants on cardiovascular endpoints were identified through this review; however, the majority of the studies revealed that short-term exposure to air pollution is associated with adverse cardiovascular events and disturbances in autonomic function in persons living with CAD.The adverse effects were dependent on the type of pollutant, the site of exposure measurement (personal versus ambient), and whether patients were taking beta-blocker medication [18][19][20].

Short-Term Risks of Air Pollution
There is considerable research demonstrating the long-term effects of exposure to air pollution on the risk for cardiovascular-related adverse events and premature mortality [45,46].For instance, the Harvard Six Cities study revealed that air pollution was directly associated with premature mortality from lung cancer and cardiopulmonary disease in 8111 adults (14 to 16-year follow-up) [47].A meta-analysis revealed that the risk for all-cause mortality was increased 0.6% (95% confidence interval, CI = 0.5-0.7)per 10 µg/m 3 elevation in PM with an aerodynamic diameter of PM 10 [48].
As outlined in this systematic review there is also compelling evidence documenting the short-term risks associated with air pollution in persons living with CAD.Research suggests that fine particles may have the greatest cardiovascular effects [45].The most commonly studied cardiovascular outcome measure in our current systematic review was HRV, a widely used non-invasive measurement of cardiovascular autonomic control [21] associated with the risk for adverse cardiovascular events, sudden cardiac death, and premature all-cause mortality [49].Compromised cardiovascular autonomic control is thought to be a mechanism between ambient air pollution and cardiovascular mortality [19,21,50].In the current systematic review, HRV was found to be negatively associated with multiple pollutants including black carbon, carbon dioxide, CO, and NO 2 as well as mass concentrations of PM 0.3-1.0 , PM 2.5 , PM 2.5-10 , PM 10 , and AMP [7,9,[18][19][20][21][22][23][24]42].Similarly, air pollution was associated with short-term risks for adverse cardiovascular events including cardiac readmissions, myocardial ischemia, angina, increased number and complexity of ventricular arrhythmias, and increased all-cause mortality [6,10,[31][32][33].Furthermore, ST-segment depression (as an indicator of myocardial ischemia) was the most common index of adverse cardiovascular effects of air pollution exposure (next to HRV).These studies revealed that ST-segment depression was associated with diesel exhaust, black carbon, and particulate air pollution [31,32,39,40] in addition to other ECG abnormalities (lengthened PR, QRS, and intervals) associated with ozone and PM 2.5 [44].Lanki and colleagues concluded that particulate air pollution originating from combustion processes (particularly traffic) exacerbated ischemic heart disease in persons living with CAD [40].Delfino and colleagues [17] also reported that exposure to organic carbon was associated with a significant increase in systolic (8.2 mmHg) and diastolic (5.8 mmHg) BP in elderly participants with CAD.Rich et al., (2012) reported ultrafine particles, PM 2.5 and AMP were associated with increased systolic blood pressure (0.94 mmHg) [42] and Sinharay et al. (2018) reported air pollution impaired benefits of exercise compared to clear air environments in adults with CAD [37].Collectively, these findings indicate that short-term air pollution exposure increases the risk of adverse cardiovascular events and disturbances in autonomic function in persons living with CAD.Moreover, this population appears to be at increased risk for adverse cardiovascular events related to air pollution.
Patients living with CAD often live with hypertension as well.However, few studies have examined the effects of air pollution on populations with coexisting hypertension and CAD.A recent study [51] revealed greater air pollution-related risks in CAD patients with pre-existing hypertension (odds ratio (OR) = 1.39; 95% CI = 1.10, 1.76) compared to normotensive patients (OR = 0.90; 95% CI = 0.66, 1.23).This preliminary research (and that of others included in this systematic review [34,36]) indicates that patients living with CAD and hypertension should pay particular attention to air pollution exposure and take appropriate steps to mitigate risks.
Beta-blocker medication likely moderates the interaction between short-term exposure to air pollution and cardiovascular function.Previous research has found that beta-blocker medication increases cardiac vagal control, which may explain the reported inconsistencies in the literature [19,36,52,53].Multiple studies in this review revealed statistically greater effects of exposure on cardiovascular function in patients who were not taking beta-blocker medication compared to those who were [18,19,38].For instance, Dales and colleagues [18] reported that patients not taking beta-blocker medication had significantly decreased indices of HRV after exposure to high levels of CO, but patients on beta-blockers showed no effects.Three of the four studies that reported no effect of air pollution on CAD patients attributed their findings to beta-blocker medication [34,36,43].These findings provide compelling evidence that beta-blocker medications may mask the cardiac effects that air pollutants have on individuals living with CAD.

Air Pollution and Exercise in Persons Living with CAD
The health benefits of routine exercise and physical activity participation for persons living with CAD are irrefutable [25].Cardiac rehabilitation is considered a global "standard of care" for the treatment of CAD [54] and has been associated with marked reductions in hospitalizations/ readmissions, and premature cardiac-and all-cause mortality [55].Risk reductions of 25-30% for premature cardiac-related mortality have been consistently observed in cardiac rehabilitation trials including both home-and centre-based trials [55].The most effective means of exercise rehabilitation have been refined throughout the years, more recently adhering to evidence-based best practice guidelines related to effective pre-participation screening, risk stratification, behaviour modification, and exercise prescription for persons living with CAD [56,57].
Air quality indicators are in use across in North America that provide recommendations to the general public regarding the risks associated with air pollution.In Canada, the AQHI is a publicly available tool that outlines the daily health risks associated with air pollution across Canada on a scale from 1 to 10 (i.e., very low to very high health risk, respectively) (Supplementary Figure S1).It provides advice about appropriate modification of outdoor physical activities during increased levels of risk, both for the general population and for those most affected by air pollution (such as people with heart and lung conditions).A similar approach has been taken in the United States with the Air Quality Index (AQI).These strategies are important examples of knowledge translation of evidence to the general public.Unfortunately, their success has been limited [58] and inclusion of recommendations related to air pollution does not occur systematically in cardiac rehabilitation settings.This is particularly important since the effectiveness and/or safety of exercise may be compromised when persons living with CAD exercise in polluted environments.
Several studies have indicated increased myocardial ischemia during exercise when persons living with CAD are exposed to air pollution [32,38,40].For instance, Lanki and colleagues [40] revealed that PM 2.5 was associated with ST segment depression during submaximal exercise testing in stable CAD patients.Similarly, brief exposure to diluted diesel exhaust exacerbated myocardial ischemia (during exercise) and inhibited endogenous fibrinolytic capacity in MI patients [32].Pekkanen and colleagues [38] reported independent associations of PM 2.5 and ultrafine particulate air pollution and ST-segment depression during repeat exercise tests in individuals living with CAD.Other adverse cardiovascular symptoms have also been demonstrated during exercise after exposure to air pollution including an earlier onset of anginal symptoms [31], and increased number, complexity, and severity of ventricular arrhythmias [33], pulse wave velocity, and augmentation index [37].
Evidence-based best practice suggests that healthcare and exercise professionals working in cardiac rehabilitation settings and/or prescribing exercise to patients with CAD should be educated themselves and be educating patients about the potential increased risk associated with exercising in more polluted environments and how to mitigate the risks associated with air pollution using air quality indicators tools such as the AQI and AQHI.

Limitations
Many of the studies that were included in this review had small sample sizes and had varied air pollution exposures and cardiovascular outcome measures.As such, there are limitations to the conclusions we can make based upon the currently published literature in the area of short-term exposure to air pollution on the cardiovascular health in adults living with CAD.The small sample sizes may make overt generalizations difficult.However, the findings from this study included patients with CAD from diverse settings and countries.It is anticipated that these findings have strong applicability to those living with CAD.
Additionally, limitations exist on the primary cardiovascular outcome measures that were used within the selected studies.Although most studies employed some form of control, heart rate variability can be affected by medication usage, fitness level, age, co-morbid conditions, and measurement conditions (e.g., exposures to caffeine or alcohol prior to measurement).This is true of other cardiovascular outcome measurements as well (e.g., arterial stiffness and blood pressure).We acknowledge that short-term exposures to air pollution do not necessarily translate/extrapolate to long-term effects.However, given that persons living with CAD are recommended to exercise, (over multiple acute bouts) our current findings demonstrate the potential cardiovascular risks associated with exercising in polluted areas and therefore, should be taken into consideration.

Recommendations
A series of key recommendations emanate from our systematic review of the literature: (1) Persons living with CAD are at an increased risk for short-term adverse cardiovascular-related events (such as strokes and exacerbation of pre-existing cardiovascular disease) and disturbances in autonomic function when exposed to air pollution in comparison to healthy individuals (1A).(2) All qualified exercise professionals and healthcare providers should be aware of the increased risks associated with exercising in polluted environments in healthy individuals and persons living with chronic medical conditions (such as CAD) (4C).( 3) Persons living with CAD should carefully monitor air quality indicators (such as the AQI and AQHI) and exercise when air pollution is lower.These cautions are given with the understanding that the health benefits of routine physical activity are marked for persons living with CAD (1A).( 4) Qualified exercise professionals and healthcare providers working within cardiac rehabilitation settings should monitor air quality indicators (such as the AQHI) and caution patients living with CAD about the short-term risks of exercising in a polluted environment.This warning should be given with the understanding that the health benefits of routine physical activity are marked for persons living with CAD (4C).( 5) Persons living with CAD should avoid exercising in areas of high air pollution (such as near high-traffic areas, factories, or during wildfires) (1A).

Future Directions
There was variability in the type of exposure and cardiovascular measurement in the studies selected, which did not allow for a meta-analysis to assess the size of the effect.However, there is strong evidence that short-term exposure to air pollution carries an increased risk for adverse cardiovascular events, particularly during exercise.Further research is required to determine the magnitude of the risk, and how to best prescribe exercise and activities while avoiding air pollutants that carry the greatest risk for those living with CAD.

Conclusions
The current systematic review of the literature provides strong evidence that persons living with CAD are at an increased risk for short-term adverse cardiovascular-related events when exposed to air pollution.These adverse risks occur during exercise in polluted environments and may be altered by beta-blocker usage.As such, persons living with CAD and their healthcare providers (including qualified exercise professionals) should carefully monitor air quality indicators (such as the AQI and AQHI) and take precautions.This includes exercising indoors when air pollution risks are higher or rescheduling outdoor exercise to when air pollution risks are lower, as well as avoiding areas of high air pollution, especially near high-traffic areas or during air pollution events such as forest fires.

Figure 1 .
Figure 1.Results of the literature search for air quality and exercise in persons living with coronary artery disease; n is an abbreviation for number.

Table 1 .
Results of the literature search regarding air pollution and health effects in persons living with coronary artery disease.

Table 2 .
Level and grade of evidence criteria for the evaluation of studies and creation of recommendations.

Table 3 .
Proportion of studies included in systematic review according to level and grade of evidence.
Note: Please refer to Table2above for grading scheme (A, B, and C).

Table 4 .
Studies included in the review related to air quality and health risks in patients with coronary artery disease.

diesel exhaust exposures
. Therefore, reduced HRV could not be attribute to pollution level.•Healthycontrolsexperiencednodifference in HRV between 2 and 24-h post-exposure.•75% of MI patients used beta-blockers during the study, however no sub-analysis available.•SO 2 exposure led to a decrease in cardiac vagal control (HRV) in healthy participants (observed 4 h after exposure of SO 2 at 200 ppm), but not patients with stable angina (HRV, heart rate, or blood pressure).•70% of patients used beta-blockers; sub-analysis not provided for medications (incl.statins and aspirin).
•Decreased pulse wave velocity and increase augmentation index in non-polluted area following exercise (26-h followup).•Inapollutedarea,with increased black carbon, NO 2 , PM 10 , PM 2.5 , and ultrafine particles, pulse wave velocity and augmentation index improvements from exercise were attenuated.•Increasedtotalmortality in MI survivors from five European cities was associated with PM 10 and particle number concentrations.•Whenlevels were averaged for longer acute periods, (5 and 15 days) CO and NO 2 were also associated with mortality.
•Adverse changes in SDNN, rMSSD, and systolic blood pressure were associated with increases in at least one of: ultrafine particles, AMP, and/or PM 2.5 within a 24-h lag period•No significant associations were found in SDNN or mean N-N.•Increased personal exposure by 10 µg/m 3 to PM 2.5 resulted in decreased HF (adjusted for beta-blockers).•Short-termO3 exposure (within 1-2 days) was significantly associated with acute MI in middle aged adults (55-64) without history of CAD.•No associations were found between acute MI and subjects with history of CAD after exposure to elevated levels of O

Table 4 .
Cont.Interquartile range increase in NO 2 significantly associated with diminished SDNN but not significantly associated with PM 2.5 .• HR was lower in patients taking beta-blocker medications; SDNN decreased in patients taking βblockers in response to 4-h ambient PM 2.5 , while patients taking bronchodilators experienced effects in the reverse direction (increased SDNN with PM 2.s exposure).