Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial

Harper, Sara A.; Roberts, Lisa M.; Layne, Andrew S.; Jaeger, Byron C.; Gardner, Anna K.; Sibille, Kimberly T.; Wu, Samuel S.; Vincent, Kevin R.; Fillingim, Roger B.; Manini, Todd M.; Buford, Thomas W.

doi:10.3390/jcm8020265

Submit to this Journal Review for this Journal Edit a Special Issue

Article Menu

...

Open AccessArticle

Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial

^1,2,†

^1,2,†,

³,

⁴

³,

³,

⁵,

⁶,

⁷,

³ and

^1,2,*

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA

Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA

Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32610, USA

⁴

Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35205, USA

⁵

Department of Biostatistics, University of Florida, Gainesville, FL 32610, USA

⁶

Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL 32610, USA

⁷

Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL 32610, USA

Author to whom correspondence should be addressed.

^†

Denotes co-first authors.

J. Clin. Med. 2019, 8(2), 265; https://doi.org/10.3390/jcm8020265

Received: 31 January 2019 / Revised: 15 February 2019 / Accepted: 18 February 2019 / Published: 21 February 2019

(This article belongs to the Special Issue Sarcopenia in Older Adults)

View Full-Text Download PDF

Browse Figures

Review Reports Citation Export

Abstract

In a pilot randomized clinical trial, participants aged ≥60 years (n = 35) with physical limitations and symptomatic knee osteoarthritis (OA) were randomized to 12 weeks of lower-body low-load resistance training with blood-flow restriction (BFR) or moderate-intensity resistance training (MIRT) to evaluate changes in muscle strength, pain, and physical function. Four exercises were performed three times per week to volitional fatigue using 20% and 60% of one repetition maximum (1RM). Study outcomes included knee extensor strength, gait speed, Short Physical Performance Battery (SPPB) performance, and pain via the Western Ontario and McMaster Universities OA Index (WOMAC). Per established guidance for pilot studies, primary analyses for the trial focused on safety, feasibility, and effect sizes/95% confidence intervals of dependent outcomes to inform a fully-powered trial. Across three speeds of movement, the pre- to post-training change in maximal isokinetic peak torque was 9.96 (5.76, 14.16) Nm while the mean difference between groups (BFR relative to MIRT) was −1.87 (−10.96, 7.23) Nm. Most other directionally favored MIRT, though more spontaneous reports of knee pain were observed (n = 14) compared to BFR (n = 3). BFR may have lower efficacy than MIRT in this context—though a fully-powered trial is needed to definitively address this hypothesis. View Full-Text

Keywords: aging; osteoarthritis; pain; function; blood-flow restriction

▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

Supplementary File 1:
ZIP-Document (ZIP, 498 KiB)

Share and Cite

MDPI and ACS Style

Harper, S.A.; Roberts, L.M.; Layne, A.S.; Jaeger, B.C.; Gardner, A.K.; Sibille, K.T.; Wu, S.S.; Vincent, K.R.; Fillingim, R.B.; Manini, T.M.; Buford, T.W. Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial. J. Clin. Med. 2019, 8, 265. https://doi.org/10.3390/jcm8020265

AMA Style

Harper SA, Roberts LM, Layne AS, Jaeger BC, Gardner AK, Sibille KT, Wu SS, Vincent KR, Fillingim RB, Manini TM, Buford TW. Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial. Journal of Clinical Medicine. 2019; 8(2):265. https://doi.org/10.3390/jcm8020265

Chicago/Turabian Style

Harper, Sara A., Lisa M. Roberts, Andrew S. Layne, Byron C. Jaeger, Anna K. Gardner, Kimberly T. Sibille, Samuel S. Wu, Kevin R. Vincent, Roger B. Fillingim, Todd M. Manini, and Thomas W. Buford. 2019. "Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial" Journal of Clinical Medicine 8, no. 2: 265. https://doi.org/10.3390/jcm8020265

Find Other Styles

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Abstract views Pdf views Html views

Article Menu

Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial

Abstract

Supplementary Material

Share and Cite

Article Metrics

Article Access Statistics

Article Access Map by Country/Region

Further Information

Guidelines

MDPI Initiatives

Follow MDPI