Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial
by
Sara A. Harper 1,2,†
, Lisa M. Roberts 1,2,†, Andrew S. Layne 3, Byron C. Jaeger 4, Anna K. Gardner 3, Kimberly T. Sibille 3, Samuel S. Wu 5, Kevin R. Vincent 6, Roger B. Fillingim 7, Todd M. Manini 3 and Thomas W. Buford 1,2,*
Sara A. Harper 1,2,†, Lisa M. Roberts 1,2,†, Andrew S. Layne 3, Byron C. Jaeger 4, Anna K. Gardner 3, Kimberly T. Sibille 3, Samuel S. Wu 5, Kevin R. Vincent 6, Roger B. Fillingim 7, Todd M. Manini 3 and Thomas W. Buford 1,2,*
1
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA
2
Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA
3
Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32610, USA
4
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35205, USA
5
Department of Biostatistics, University of Florida, Gainesville, FL 32610, USA
6
Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL 32610, USA
7
Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL 32610, USA
*
Author to whom correspondence should be addressed.
â€
Denotes co-first authors.
J. Clin. Med. 2019, 8(2), 265; https://doi.org/10.3390/jcm8020265
Received: 31 January 2019 / Revised: 15 February 2019 / Accepted: 18 February 2019 / Published: 21 February 2019
(This article belongs to the Special Issue Sarcopenia in Older Adults)
In a pilot randomized clinical trial, participants aged ≥60 years (n = 35) with physical limitations and symptomatic knee osteoarthritis (OA) were randomized to 12 weeks of lower-body low-load resistance training with blood-flow restriction (BFR) or moderate-intensity resistance training (MIRT) to evaluate changes in muscle strength, pain, and physical function. Four exercises were performed three times per week to volitional fatigue using 20% and 60% of one repetition maximum (1RM). Study outcomes included knee extensor strength, gait speed, Short Physical Performance Battery (SPPB) performance, and pain via the Western Ontario and McMaster Universities OA Index (WOMAC). Per established guidance for pilot studies, primary analyses for the trial focused on safety, feasibility, and effect sizes/95% confidence intervals of dependent outcomes to inform a fully-powered trial. Across three speeds of movement, the pre- to post-training change in maximal isokinetic peak torque was 9.96 (5.76, 14.16) Nm while the mean difference between groups (BFR relative to MIRT) was −1.87 (−10.96, 7.23) Nm. Most other directionally favored MIRT, though more spontaneous reports of knee pain were observed (n = 14) compared to BFR (n = 3). BFR may have lower efficacy than MIRT in this context—though a fully-powered trial is needed to definitively address this hypothesis.
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Keywords:
aging; osteoarthritis; pain; function; blood-flow restriction
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MDPI and ACS Style
Harper, S.A.; Roberts, L.M.; Layne, A.S.; Jaeger, B.C.; Gardner, A.K.; Sibille, K.T.; Wu, S.S.; Vincent, K.R.; Fillingim, R.B.; Manini, T.M.; Buford, T.W. Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial. J. Clin. Med. 2019, 8, 265.
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