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Clinical Trends and Prospects in Laboratory Hematology
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Clinical Trends and Prospects in Laboratory Hematology

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Laboratory Medicine".

Deadline for manuscript submissions: 25 October 2025 | Viewed by 281

Special Issue Editor

Prof. Dr. Olga Ciepiela

E-Mail Website1 Website2
Guest Editor
Department of Laboratory Medicine, Medical University of Warsaw, Banacha 1a Street, 02-097 Warsaw, Poland
Interests: laboratory medicine; hematology; immunology; plasma cell dyscrasias; electrophoresis; flow cytometry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nowadays, we observe extreme progress in the development of laboratory hematology. All clinical decisions for patients with hematological disorders have to be based on the results of laboratory investigations, including basic tests like complete blood count and hemostatic tests through specialized flow cytometric or electrophoretic analyses to personalized molecular diagnostics. Clinical laboratory specialists working in the field of laboratory hematology put huge effort into providing comprehensive, detailed, and precise laboratory test results in the shortest possible time. Advances in laboratory hematology are not fully recognized by clinicians; thus, we should widely present actual possibilities of laboratory medicine and bring the recent achievements in the hematological field closer to clinics. In this Special Issue, we welcome authors to submit papers on the latest advances in all areas of laboratory hematology, including the clinical evaluation of new methods and laboratory equipment as well as clinical studies based on laboratory evaluation.

Prof. Dr. Olga Ciepiela
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • laboratory hematology
  • hemostasis
  • flow cytometry
  • molecular diagnostics
  • blood cells
  • complete blood count

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Published Papers (1 paper)

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Research

10 pages, 462 KiB  
Article
Accuracy of Red Blood Cell Parameters in Predicting α0-Thalassemia Trait Among Non-Anemic Males
by Benchaya Phanthong, Pimlak Charoenkwan, Threebhorn Kamlungkuea, Suchaya Luewan and Threea Tongsong
J. Clin. Med. 2025, 14(10), 3591; https://doi.org/10.3390/jcm14103591 - 21 May 2025
Viewed by 27
Abstract
Background/Objectives: Red blood cell (RBC) parameters are routinely used to screen for α- and β-thalassemia traits as part of prenatal diagnosis for severe fetal thalassemia in countries with a high prevalence of the disease. In clinical practice, the same cut-off values for [...] Read more.
Background/Objectives: Red blood cell (RBC) parameters are routinely used to screen for α- and β-thalassemia traits as part of prenatal diagnosis for severe fetal thalassemia in countries with a high prevalence of the disease. In clinical practice, the same cut-off values for these parameters are applied to both females and males. However, given that the normal reference ranges for some RBC parameters differ significantly between sexes, sex-specific cut-off values may be more appropriate, especially in combination. To date, the effectiveness of RBC indices in males for predicting α- and β-thalassemia traits has not been evaluated. The objectives of this study are to assess the diagnostic performance of individual and combined RBC parameters in detecting α0-thalassemia traits among non-anemic males. Methods: This diagnostic study is a secondary analysis of prospectively collected data from our project on prenatal control of severe thalassemia. The study population comprised male partners of pregnant women who underwent thalassemia screening during their first antenatal visit. RBC parameters, including hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), and RBC count, were measured for each participant. Carrier status for the α0-thalassemia Southeast Asian (SEA) genotype was confirmed by using a polymerase chain reaction (PCR)-based method. The diagnostic performance of each RBC parameter and their combinations, based on predictive models generated using logistic regression, was evaluated and compared using receiver operating characteristic (ROC) curves. Results: A total of 486 Thai males were recruited for the study, including 137 individuals with the α0-thalassemia trait and 349 with a normal α-thalassemia genotype (control group). All RBC parameters, except for Hct, differed significantly between the two groups. Among the individual indices, MCH exhibited the highest diagnostic accuracy, followed by MCV, with areas under the curve (AUCs) of 0.981 and 0.973, respectively. An MCH cut-off value of 26 pg and an MCV cut-off value of 80 fL provided a sensitivity of 100% for both indices, with specificities of 88.5% and 86.8%, respectively. The combination predictive model provided the best diagnostic performance, achieving an AUC of 0.987, which was slightly but significantly higher than that of any individual parameter. This model yielded a sensitivity of 100% and a significantly higher specificity of 90.8% at a cut-off probability of 7.0%. Conclusions: MCH and MCV demonstrated excellent screening performance for identifying α0-thalassemia carriers in males. However, the combination model exhibited even greater accuracy while reducing the false-positive rate. Implementing this model could minimize the need for unnecessary PCR testing, leading to substantial cost savings. Full article
(This article belongs to the Special Issue Clinical Trends and Prospects in Laboratory Hematology)
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