jcm-logo

Journal Browser

Journal Browser

Innovations in the Treatment for Depression and Anxiety

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 165

Special Issue Editor


E-Mail Website
Guest Editor
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
Interests: psychopharmacotherapy; antidepressant agents; affective disorders; depression; anxiety; major depressive disorder; treatment-resistant depression

Special Issue Information

Dear Colleagues,

We are very delighted to cordially invite you to contribute to our upcoming Special Issue titled “Innovations in the Treatment for Depression and Anxiety”, which seeks to address some of the most exciting and pressing challenges in the management of these widespread mental health conditions.

Depression and anxiety continue to impose significant burdens on individuals and families, as well as healthcare and socioeconomic systems worldwide. Despite advances in understanding their underlying mechanisms, clinical manifestations, and treatments, insufficient symptom relief and the need for more personalized and accessible care remain critical issues. This Special Issue aims to explore novel approaches and interdisciplinary strategies that hold promise for overcoming these barriers.

We welcome submissions covering a broad range of topics, including advancements in pharmacological treatments, neuromodulation techniques, digital and telehealth interventions, psychotherapeutic innovations, and integrated care models. Studies investigating biomarkers, neurobiological underpinnings, and precision medicine approaches are also highly encouraged. Research focusing on underserved populations, comorbidities, and scalable treatment options will provide valuable insights for real-world applications.

This Special Issue aims to foster collaboration among researchers and clinicians, driving the translation of emerging findings into practical treatments that will improve patient outcomes.

We encourage you to submit original research articles and reviews that contribute to this critical and dynamic field.

We look forward to your valuable contributions and the opportunity to advance the future of mental healthcare together.

With my very best wishes, many thanks and kindest regards from Vienna.

Dr. Lucie Bartova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • depression
  • anxiety
  • antidepressant
  • anxiolytic
  • psychopharmacotherapy
  • psychotherapy
  • brain stimulation
  • treatment
  • response
  • resistance

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

20 pages, 642 KiB  
Review
Efficacy and Safety of Transcranial Magnetic Stimulation for Treating Late-Life Depression: A Scoping Review
by Ciprian-Ionuț Băcilă, Monica Cornea, Andrei Lomnasan, Claudia Elena Anghel, Andreea Maria Grama, Cristina Elena Dobre, Silvia Rusu and Bogdan Ioan Vintilă
J. Clin. Med. 2025, 14(10), 3609; https://doi.org/10.3390/jcm14103609 - 21 May 2025
Abstract
Background/Objectives: Transcranial magnetic stimulation (TMS) is a non-invasive and well-tolerated treatment, offering an effective alternative for elderly patients with depression, especially when side effects or comorbidities limit medication. Methods: This scoping review analyzes 16 studies published over the past seven years, [...] Read more.
Background/Objectives: Transcranial magnetic stimulation (TMS) is a non-invasive and well-tolerated treatment, offering an effective alternative for elderly patients with depression, especially when side effects or comorbidities limit medication. Methods: This scoping review analyzes 16 studies published over the past seven years, to evaluate the efficacy, safety, and clinical applications of TMS in older adults with depression. Results: The review examines various TMS modalities, including repetitive TMS (rTMS), deep TMS, and theta burst stimulation (TBS), with most protocols targeting the dorsolateral prefrontal cortex (DLPFC). Adverse effects were rare, mild, and transient, supporting the treatment’s safety profile. Pharmacological co-treatment was common but not essential for clinical improvement, highlighting TMS’s potential as a standalone therapy. A subset of studies used neuroplasticity (SICI, ICF, CSP) or neuroimaging measures (MRI and MRI-based neuronavigation), revealing that age-related cortical inhibition may limit plasticity rather than depression itself. Conclusions: Overall, TMS demonstrates promising effectiveness and tolerability in managing late-life depression. Across studies, remission rates varied from 20% to 63%, with higher efficacy generally observed in bilateral stimulation or high-frequency protocols. Standardization of protocols and further research into individualized targeting and long-term outcomes are warranted to support broader clinical adoption. Full article
(This article belongs to the Special Issue Innovations in the Treatment for Depression and Anxiety)
Show Figures

Figure 1

Back to TopTop