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Journal of Clinical Medicine, Volume 11, Issue 9

2022 May-1 - 407 articles

Cover Story: Cardiovascular development in higher vertebrates involves a number of complex processes that are temporally and spatially orchestrated: migration, proliferation, differentiation, programmed cell death, and interaction of cardiac progenitor cells of different origins. In order to better understand this complex process, it may be helpful to divide it into several regions or steps. As a matter of fact, most congenital heart diseases that we encounter in our daily practice are specific developmental abnormalities in one of these regions. Therefore, this concept is also important for understanding the etiology of congenital heart disease. View this paper
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Articles (407)

  • Review
  • Open Access
15 Citations
5,638 Views
12 Pages

COVID-19 Vaccination in Inflammatory Bowel Disease (IBD)

  • Aleksandra Kubas and
  • Ewa Malecka-Wojciesko

Vaccines against SARS-CoV-2 are believed to play a key role in the suppression of the COVID-19 pandemic. However, patients suffering from inflammatory bowel diseases (IBD) were excluded from SARS-CoV-2 vaccines trials. Therefore, concerns regarding v...

(This article belongs to the Special Issue Advances in Inflammatory Bowel Disease)
  • Article
  • Open Access
5 Citations
3,137 Views
9 Pages

The Accuracy of Jaws Repositioning in Bimaxillary Orthognathic Surgery in Patients with Cleft Lip and Palate Compared to Non-Syndromic Skeletal Class III Patients

  • Benedetta Bollato,
  • Martina Barone,
  • Antonio Gracco,
  • Ugo Baciliero and ,
  • Giorgia Crivellin,
  • Giovanni Bruno and
  • Alberto De Stefani
  • + 2 authors+ 0 author

Background: The present study aims to compare the accuracy of jaw repositioning in bimaxillary orthognathic surgery using digital surgical planning in cleft lip and palate patients and in non-syndromic skeletal class III patients in order to investig...

(This article belongs to the Special Issue Breakthroughs in Oral and Maxillofacial Surgery)
  • Article
  • Open Access
5 Citations
3,440 Views
11 Pages

90-Day Patient-Centered Outcomes after Totally Endoscopic Cardiac Surgery: A Prospective Cohort Study

  • Jade Claessens,
  • Alaaddin Yilmaz,
  • Toon Mostien,
  • Silke Van Genechten and ,
  • Marithé Claes,
  • Loren Packlé,
  • Maud Pierson,
  • Jeroen Vandenbrande,
  • Abdullah Kaya and
  • Björn Stessel
  • + 5 authors+ 0 author

Over the past years, minimally invasive procedures have been developed to reduce surgical trauma after cardiac surgery. The value of patient-centered outcomes, including the quality of recovery after hospital discharge, is increasingly recognized. Id...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
17 Citations
4,739 Views
9 Pages

Standardization of Post-Vitrification Human Blastocyst Expansion as a Tool for Implantation Prediction

  • Anat Hershko-Klement,
  • Shaul Raviv,
  • Luba Nemerovsky,
  • Tal Rom and ,
  • Ayelet Itskovich,
  • Danit Bakhshi,
  • Adrian Shulman and
  • Yehudith Ghetler
  • + 3 authors+ 0 author

The increased use of vitrified blastocysts has encouraged the development of various criteria for selecting the embryo most likely to implant. Post-thaw assessment methods and timetables vary among investigators. We investigated the predictive value...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
8 Citations
3,504 Views
12 Pages

Efficacy and Safety of Naldemedine for Patients with Cancer with Opioid-Induced Constipation in Clinical Practice: A Real-World Retrospective Study

  • Hiromi Nishiba,
  • Hisao Imai,
  • Yukiyoshi Fujita,
  • Eriko Hiruta and ,
  • Takashi Masuno,
  • Shigeki Yamazaki,
  • Hajime Tanaka,
  • Teruhiko Kamiya,
  • Masako Ito and
  • Kyoko Obayashi
  • + 9 authors+ 4 authors

The efficacy and safety of naldemedine for opioid-induced constipation in patients with cancer has not been investigated in clinical practice. We conducted a multicenter, retrospective study to assess the effects of naldemedine among 10 Japanese inst...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
8 Citations
4,489 Views
14 Pages

Relationship of Different Anthropometric Indices with Vascular Ageing in an Adult Population without Cardiovascular Disease—EVA Study

  • Leticia Gómez-Sánchez,
  • Marta Gómez-Sánchez,
  • Emiliano Rodríguez-Sánchez,
  • Carmen Patino-Alonso and ,
  • Rosario Alonso-Dominguez,
  • Natalia Sanchez-Aguadero,
  • Cristina Lugones-Sánchez,
  • Ines Llamas-Ramos,
  • Luis García-Ortiz and
  • on behalf of the EVA Investigators
  • + 6 authors+ 1 author

The objectives of this study were to analyse the capacity of different anthropometric indices to predict vascular ageing and this association in Spanish adult population without cardiovascular disease. A total of 501 individuals without cardiovascula...

(This article belongs to the Collection Obesity: From Diagnosis to Treatment)
  • Article
  • Open Access
10 Citations
4,471 Views
11 Pages

Determinants in the Underdiagnosis of COPD in Spain—CONOCEPOC Study

  • Myriam Calle Rubio,
  • Juan Luis Rodríguez Hermosa,
  • Marc Miravitlles and
  • José Luis López-Campos

Factors such as seeking medical attention for respiratory symptoms and health professionals ordering spirometry come into play in the underdiagnosis of chronic obstructive pulmonary disease (COPD). The objective of this study was to analyze seeking m...

(This article belongs to the Section Respiratory Medicine)
  • Review
  • Open Access
10 Citations
3,738 Views
12 Pages

Wound-Related Complication in Growth-Friendly Spinal Surgeries for Early-Onset Scoliosis—Literature Review

  • Michał Latalski,
  • Grzegorz Starobrat,
  • Marek Fatyga,
  • Ireneusz Sowa and ,
  • Magdalena Wójciak,
  • Joanna Wessely-Szponder,
  • Sławomir Dresler and
  • Anna Danielewicz
  • + 3 authors+ 0 author

Background: The treatment for early-onset scoliosis (EOS) is one of the most challenging for pediatric orthopedics. Surgical treatment is often necessary, and wound problems and surgical site infections (SSIs) are common, with potentially severe comp...

(This article belongs to the Special Issue The Diagnosis and Treatment of Spinal Infections)
  • Article
  • Open Access
10 Citations
3,127 Views
17 Pages

Impact of Type 2 Diabetes Mellitus on the Incidence and Outcomes of COVID-19 Needing Hospital Admission According to Sex: Retrospective Cohort Study Using Hospital Discharge Data in Spain, Year 2020

  • Jose M. de Miguel-Yanes,
  • Rodrigo Jimenez-Garcia,
  • Javier de Miguel-Diez,
  • Valentin Hernández-Barrera and ,
  • David Carabantes-Alarcon,
  • Jose J. Zamorano-Leon,
  • Ricardo Omaña-Palanco and
  • Ana Lopez-de-Andres
  • + 3 authors+ 0 author

(1) Background: To analyze incidence and in-hospital mortality (IHM) of COVID-19 needing hospital admission in Spain (2020) in patients with T2DM. (2) Methods: We conducted a retrospective cohort study. Using the Spanish Register of Specialized Care-...

(This article belongs to the Special Issue Diabetes Epidemiology, Prevention and Treatment)
  • Article
  • Open Access
30 Citations
6,111 Views
9 Pages

Preoperative Anxiety in the Surgical Transfer and Waiting Area: A Cross-Sectional Mixed Method Study

  • Mikhail Dziadzko,
  • Tessa Mazard,
  • Myriam Bonhomme,
  • Mahé Raffin and ,
  • Pierre Pradat,
  • Jean-Marc Forcione,
  • Raphael Minjard and
  • Frederic Aubrun
  • + 3 authors+ 0 author

Severe preoperative anxiety (SPA) in surgical patients may have clinical consequences and worsen satisfaction. Some institutions have a surgical transfer and waiting area (TWA) for patient reception/dispatch to operating rooms. We measured the freque...

(This article belongs to the Special Issue Delivery of Anesthesia: Pre-Operative and Post-Operative)
  • Article
  • Open Access
18 Citations
4,125 Views
13 Pages

Sagittal Condylar Inclination and Transversal Condylar Inclination in Different Skeletal Classes

  • Anahit Lewandowska,
  • Katarzyna Mańka-Malara and
  • Jolanta Kostrzewa-Janicka

Background: During prosthodontic treatment, the averaged values of the transversal condylar inclination (TCI) and the sagittal condylar inclination (SCI) are used for articulator settings. This study evaluated different parameters of measurable mandi...

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
  • Article
  • Open Access
4 Citations
2,404 Views
8 Pages

Tricuspid Structural Valve Deterioration Treated with a Transcatheter Valve-in-Valve Implantation: A Single-Center Prospective Registry

  • Nili Schamroth Pravda,
  • Hana Vaknin Assa,
  • Amos Levi,
  • Guy Witberg and ,
  • Yaron Shapira,
  • Mordechai Vaturi,
  • Katia Orvin,
  • Yeela Talmor Barkan,
  • Ashraf Hamdan and
  • Pablo Codner
  • + 10 authors+ 5 authors

The valve-in-valve (ViV) technique is an emerging alternative for the treatment of bioprosthetic structural valve deterioration (SVD) in the tricuspid position. We report on the outcomes of patients treated by a transcatheter tricuspid valve-in-valve...

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
41 Citations
5,880 Views
14 Pages

Triglyceride-Glucose Index for Early Prediction of Nonalcoholic Fatty Liver Disease: A Meta-Analysis of 121,975 Individuals

  • Azizullah Beran,
  • Hazem Ayesh,
  • Mohammed Mhanna,
  • Waseem Wahood and ,
  • Sami Ghazaleh,
  • Ziad Abuhelwa,
  • Wasef Sayeh,
  • Nameer Aladamat,
  • Rami Musallam and
  • Ragheb Assaly
  • + 7 authors+ 2 authors

Insulin resistance (IR) is a major contributor to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index has recently gained popularity for the assessment of IR and NAFLD due to its ease of acquisition and...

(This article belongs to the Special Issue Clinical Research Advances in Non-alcoholic Fatty Liver Disease)
  • Article
  • Open Access
32 Citations
3,243 Views
12 Pages

Marginal versus Standard Donors in Heart Transplantation: Proper Selection Means Heart Transplant Benefit

  • Olimpia Bifulco,
  • Tomaso Bottio,
  • Raphael Caraffa,
  • Massimiliano Carrozzini and ,
  • Alvise Guariento,
  • Jonida Bejko,
  • Marny Fedrigo,
  • Chiara Castellani,
  • Giuseppe Toscano and
  • Gino Gerosa
  • + 12 authors+ 7 authors

Background: In this study, we assessed the mid-term outcomes of patients who received a heart donation from a marginal donor (MD), and compared them with those who received an organ from a standard donor (SD). Methods: All patients who underwent HTx...

(This article belongs to the Special Issue Surgical Treatment of End Stage Heart Failure)
  • Review
  • Open Access
14 Citations
8,254 Views
17 Pages

Lifestyle Modification and Atrial Fibrillation: Critical Care for Successful Ablation

  • John L. Fitzgerald,
  • Melissa E. Middeldorp,
  • Celine Gallagher and
  • Prashanthan Sanders

Management of atrial fibrillation (AF) requires a comprehensive approach due to the limited success of medical or procedural approaches in isolation. Multiple modifiable risk factors contribute to the development and progression of the underlying sub...

(This article belongs to the Special Issue Current Practice and Future Perspectives in Ablation of Atrial Fibrillation)
  • Article
  • Open Access
11 Citations
2,825 Views
12 Pages

Impact of SARS-CoV-2 Alpha and Gamma Variants among Symptomatic Pregnant Women: A Two-Center Retrospective Cohort Study between France and Brazil

  • Elie Mosnino,
  • Lisandra S. Bernardes,
  • Jeremie Mattern,
  • Bruna Hipólito Micheletti and ,
  • Amarilis Aparecida de Castro Maldonado,
  • Christelle Vauloup-Fellous,
  • Florence Doucet-Populaire,
  • Daniele De Luca,
  • Alexandra Benachi and
  • Alexandre J. Vivanti
  • + 5 authors+ 0 author

New variants of SARS-CoV-2 are a major source of concern, especially for pregnant women and in the perinatal context. The primary aim of this study was to compare the severity of COVID-19 infection in pregnant women depending on strain predominance b...

(This article belongs to the Section Obstetrics & Gynecology)
  • Review
  • Open Access
25 Citations
9,436 Views
10 Pages

A significant proportion of patients with a severe traumatic brain injury (TBI) have hypoalbuminemia and require fluid resuscitation. Intravenous fluids can have both favorable and unfavorable consequences because of the risk of hyperhydration and hy...

(This article belongs to the Special Issue Critical Care Update: Innovations in Diagnostic & Treatment)
  • Article
  • Open Access
9 Citations
4,807 Views
10 Pages

Coracoid Impingement and Morphology Is Associated with Fatty Infiltration and Rotator Cuff Tears

  • Saadiq F. El-Amin,
  • Nicola Maffulli,
  • Matthew C. Mai,
  • Hugo C. Rodriguez and ,
  • Victoria Jaso,
  • Dylan Cannon and
  • Ashim Gupta
  • + 2 authors+ 0 author

This study describes measurements between the coracoid, glenoid, and humerus; characterizes coracoid shape, rotator cuff fatty infiltration, and quantitatively evaluates coracoid impingement and its association with anterosuperior rotator cuff tears...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
3 Citations
6,571 Views
8 Pages

Duodenal Gastric Metaplasia and Duodenal Neuroendocrine Neoplasms: More Than a Simple Coincidence?

  • Sara Massironi,
  • Roberta Elisa Rossi,
  • Anna Caterina Milanetto,
  • Valentina Andreasi and ,
  • Davide Campana,
  • Gennaro Nappo,
  • Stefano Partelli,
  • Camilla Gallo,
  • Miki Scaravaglio and
  • on behalf of ItaNet (Italian Association for Neuroendocrine Tumours) Study Group
  • + 10 authors+ 5 authors

Background: Duodenal gastric metaplasia (DGM) is considered a precancerous lesion. No data are available regarding its possible role as a risk factor for duodenal neuroendocrine neoplasms (dNENs). Aims: To assess the prevalence of DGM in a cohort of...

(This article belongs to the Special Issue Neuroendocrine Tumors: Etiology, Diagnosis, and Therapy)
  • Article
  • Open Access
1 Citations
2,839 Views
10 Pages

Survival Impact of Residual Cancer Cells in Intraoperative Peritoneal Washes following Radical Hysterectomy for Cervical Cancer

  • Jong Mi Kim,
  • Gun Oh Chong,
  • Nora Jee-Young Park,
  • Yeong Eun Choi and ,
  • Juhun Lee,
  • Yoon Hee Lee,
  • Dae Gy Hong and
  • Ji Young Park
  • + 3 authors+ 0 author

Objective: Residual cancer cells (RCCs) contribute to cancer recurrence either because of tumor spillage or undetectable pre-existing micrometastatic tumor clones. We hypothesized that the pathologic evaluation of intraoperative peritoneal washes may...

(This article belongs to the Special Issue New Directions in the Treatment of Gynecological Cancers)
  • Article
  • Open Access
14 Citations
7,971 Views
10 Pages

Laparoscopic Fluorescence Guided Detection of Uterine Niche—The Next Step in Surgical Diagnosis and Treatment

  • Harald Krentel,
  • Lisa-Kathrin Lauterbach,
  • Georgios Mavrogiannis and
  • Rudy Leon De Wilde

(1) Background: Uterine niche is a frequent condition in patients with a history of cesarean section. Although the relation to uterotomy seems to be clear, the exact pathogenesis is not fully understood. Uterine niche can easily be diagnosed by trans...

(This article belongs to the Special Issue Challenges and Controversies in Minimally Invasive Surgery: What Is Really New in Gynecologic Surgery?)
  • Article
  • Open Access
23 Citations
3,499 Views
16 Pages

Sarcopenia and Myosteatosis Are Associated with Neutrophil to Lymphocyte Ratio but Not Glasgow Prognostic Score in Colorectal Cancer Patients

  • Raila Aro,
  • Sanna Meriläinen,
  • Päivi Sirniö,
  • Juha P. Väyrynen and ,
  • Vesa-Matti Pohjanen,
  • Karl-Heinz Herzig,
  • Tero T. Rautio,
  • Elisa Mäkäräinen,
  • Reetta Häivälä and
  • Anne Tuomisto
  • + 8 authors+ 3 authors

Cancer patients commonly present sarcopenia, myosteatosis, and systemic inflammation, which are risk factors of poor survival. In this study, sarcopenia and myosteatosis were defined from preoperative body computed tomography scans of 222 colorectal...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
13 Citations
3,422 Views
13 Pages

Matrix Metaloproteinase-9 (MMP-9) and Tissue Inhibitor of Metaloproteinase-1 (TIMP-1), enzymes involved in tissue remodelling, have been previously reported to be overexpressed in the colonic mucosa of patients with Ulcerative colitis (UC). The aim o...

(This article belongs to the Section Clinical Pediatrics)
  • Article
  • Open Access
11 Citations
4,236 Views
12 Pages

Past studies have confirmed that glucagon-like peptide 1 (GLP-1) receptor agonists can improve renal outcomes in patients with type 2 diabetes mellitus (DM). This study aimed to evaluate whether dipeptidyl peptidase 4 (DPP-4) inhibitors, which elevat...

(This article belongs to the Section Nephrology & Urology)
  • Article
  • Open Access
4 Citations
2,947 Views
12 Pages

High Levels of Thromboxane (TX) Are Associated with the Sex-Dependent Non-Dipping Phenomenon in Ischemic Stroke Patients

  • Arleta Drozd,
  • Małgorzata Szczuko,
  • Andrzej Bohatyrewicz,
  • Alina Jurewicz and
  • Dariusz Kotlęga

Background: Inflammation and high blood pressure (nondipping profile) during the rest/sleep period have been associated with an effect on the incidence of cardiovascular disorders and a more severe course in the ischemic cerebrovascular event. There...

(This article belongs to the Special Issue Diagnosis and Management of Arterial Hypertension: State of the Art and Current Challenges)
  • Article
  • Open Access
22 Citations
4,336 Views
11 Pages

Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences

  • María Isabel Biezma,
  • Patricia Muñoz,
  • Sofía De la Villa,
  • Mª Carmen Fariñas-Álvarez and ,
  • Francisco Arnáiz de las Revillas,
  • Encarnación Gutierrez-Carretero,
  • Arístides De Alarcón,
  • Raquel Rodríguez-García,
  • Jaume Llopis and
  • on behalf of GAMES
  • + 10 authors+ 5 authors

Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognost...

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
9 Citations
4,702 Views
12 Pages

Target Low-Density Lipoprotein-Cholesterol and Secondary Prevention for Patients with Acute Myocardial Infarction: A Korean Nationwide Cohort Study

  • Ju Hyeon Kim,
  • Jung-Joon Cha,
  • Subin Lim,
  • Jungseok An and ,
  • Mi-Na Kim,
  • Soon Jun Hong,
  • Hyung Joon Joo,
  • Jae Hyoung Park,
  • Cheol Woong Yu and
  • Tae Hoon Ahn
  • + 13 authors+ 8 authors

Although lowering low-density lipoprotein cholesterol (LDL-C) levels following acute myocardial infarction (MI) is the cornerstone of secondary prevention, the attainment of recommended LDL-C goals remains suboptimal in real-world practice. We sought...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
8 Citations
3,200 Views
9 Pages

Evaluating Ocular Symptoms and Tear Film Cytokine Profiles in Symptomatic COVID-19 Patients

  • Anna Niedźwiedź,
  • Miłosz Kawa,
  • Ewa Pius-Sadowska,
  • Agnieszka Kuligowska and ,
  • Alicja Ziontkowska,
  • Dawid Wrzałek,
  • Miłosz Parczewski,
  • Krzysztof Safranow,
  • Krzysztof Kozłowski and
  • Anna Machalińska
  • + 6 authors+ 1 author

Background: This study investigated the presence and duration of ophthalmic symptoms in the early phase of COVID-19 to assess the corresponding local immune response on the ocular surface. Methods: The study included data from 180 COVID-19 patients a...

(This article belongs to the Special Issue COVID-19: Special Populations and Risk Factors)
  • Brief Report
  • Open Access
7 Citations
4,520 Views
4 Pages

Humoral and T-Cell Response before and after a Fourth BNT162b2 Vaccine Dose in Adults ≥60 Years

  • Erez Bar-Haim,
  • Noa Eliakim-Raz,
  • Amos Stemmer,
  • Hila Cohen and ,
  • Uri Elia,
  • Asaf Ness,
  • Muhammad Awwad,
  • Nassem Ghantous,
  • Neta Moskovits and
  • Salomon M. Stemmer
  • + 6 authors+ 1 author

Both humoral and cellular anamnestic responses are significant for protective immunity against SARS-CoV-2. In the current study, the responses in elderly people before and after a fourth vaccine dose of BNT162b2 were compared to those of individuals...

(This article belongs to the Special Issue COVID-19: Clinical Advances and Challenges)
  • Article
  • Open Access
18 Citations
4,258 Views
11 Pages

Background: Propofol is considered to protect against immunosuppression and has lower inflammatory responses in the perioperative period than volatile agents. We evaluated whether the anesthetic agent is associated with cancer outcomes. Methods: We r...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Case Report
  • Open Access
5 Citations
6,164 Views
10 Pages

A Modified Approach for Ultrasound-Guided Thoracic Paravertebral Block via Thoracic Intervertebral Foramen in an Adolescent Patient: A Case Report

  • Emiliano Petrucci,
  • Franco Marinangeli,
  • Barbara Pizzi,
  • Francesco Sciorio and ,
  • Gioele Marrocco,
  • Massimo Antonio Innamorato,
  • Marco Cascella and
  • Alessandro Vittori
  • + 3 authors+ 0 author

This case report describes a modified approach for a thoracic paravertebral block by performing a bilateral ultrasound-assisted injection of 12 mL of 0.5% levobupivacaine near the thoracic intervertebral foramen, combined with general anesthesia, in...

(This article belongs to the Special Issue Advances in Postoperative Pain Management and Chronic Postoperative Pain)
  • Article
  • Open Access
2 Citations
3,675 Views
10 Pages

COVID-19 Quarantine Dramatically Affected Male Sexual Behavior: Is There a Possibility to Go Back to Normality?

  • Lorenzo Spirito,
  • Michele Morelli,
  • Roberto La Rocca,
  • Luigi Napolitano and ,
  • Claudia Collà Ruvolo,
  • Lorenzo Romano,
  • Angelo di Giovanni,
  • Carmine Sciorio,
  • Sergio Concetti and
  • Marco Capece
  • + 8 authors+ 3 authors

We performed a monocentric longitudinal study on sexually active male patients, from May 2021 to October 2021, with SARS-CoV-2 infection confirmed with a nasopharyngeal reverse transcriptase polymerase chain reaction (RT-PCR). The questionnaires were...

(This article belongs to the Section Reproductive Medicine & Andrology)
  • Article
  • Open Access
11 Citations
3,284 Views
10 Pages

Comparison of the Oncological Outcomes of Open versus Laparoscopic Surgery for T2 Gallbladder Cancer: A Propensity-Score-Matched Analysis

  • Jin-Kyu Cho,
  • Jae-Ri Kim,
  • Jae-Yool Jang,
  • Han-Gil Kim and ,
  • Jae-Myung Kim,
  • Seung-Jin Kwag,
  • Ji-Ho Park,
  • Ju-Yeon Kim,
  • Young-Tae Ju and
  • Chi-Young Jeong
  • + 5 authors+ 0 author

Although laparoscopic treatment for T1 gallbladder cancer (GBC) has been described previously, the differences in oncologic outcomes between laparoscopic and conventional open surgery for T2 GBC have not been investigated. We aimed to assess the role...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
35 Citations
4,076 Views
12 Pages

Effects of Remimazolam vs. Sevoflurane Anesthesia on Intraoperative Hemodynamics in Patients with Gastric Cancer Undergoing Robotic Gastrectomy: A Propensity Score-Matched Analysis

  • Bahn Lee,
  • Myoung Hwa Kim,
  • Hee Jung Kong,
  • Hye Jung Shin and ,
  • Sunmo Yang,
  • Na Young Kim and
  • Dongwoo Chae
  • + 2 authors+ 0 author

Remimazolam has been suggested to improve the maintenance of hemodynamic stability when compared with other agents used for general anesthesia. This study aimed to compare the effects of remimazolam and sevoflurane anesthesia on hemodynamic stability...

(This article belongs to the Special Issue New Approaches in Intravenous Anesthesia and Anesthetics—Part II)
  • Article
  • Open Access
4 Citations
2,372 Views
13 Pages

Compartment-Specific Differences in the Activation of Monocyte Subpopulations Are Not Affected by Nitric Oxide and Glucocorticoid Treatment in a Model of Resuscitated Porcine Endotoxemic Shock

  • Tomasz Skirecki,
  • Barbara Adamik,
  • Claes Frostell,
  • Urszula Pasławska and ,
  • Stanisław Zieliński,
  • Natalia Glatzel-Plucińska,
  • Mateusz Olbromski,
  • Piotr Dzięgiel and
  • Waldemar Gozdzik
  • + 4 authors+ 0 author

Inhaled nitric oxide (iNO) remains one of the treatment modalities in shock, and in addition to its vasoactive properties, iNO exerts immunomodulatory effects. We used a porcine model of endotoxemia with shock resuscitation (control) and additional t...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
25 Citations
10,856 Views
20 Pages

In this article, the effects of cross-section and pitch on the mechanical response of NiTi endodontic files is studied by means of finite element analyses. The study was conducted over a set of eight endodontic rotary files, whose geometry was obtain...

(This article belongs to the Special Issue The State of the Art in Endodontics)
  • Article
  • Open Access
57 Citations
7,670 Views
10 Pages

Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study

  • Lorenzo Moretti,
  • Giuseppe Maccagnano,
  • Michele Coviello,
  • Giuseppe D. Cassano and ,
  • Andrea Franchini,
  • Andrea Laneve and
  • Biagio Moretti
  • + 2 authors+ 0 author

Background: The aim of this prospective study was to evaluate the efficacy and safety of Platelet Rich Plasma (PRP) injections in patients affected by knee osteoarthritis (KOA). An autologous blood product containing a high percentage of various grow...

(This article belongs to the Special Issue Strategies for the Prevention of Knee Osteoarthritis)
  • Article
  • Open Access
7 Citations
2,317 Views
14 Pages

Real-Life Early Anthropometric, Lipid and Liver Changes after Direct-Acting Antiviral Therapy in PLWHIV with HCV Co-Infection

  • Sergio Ferra-Murcia,
  • Antonio Ramón Collado-Romacho,
  • Bruno José Nievas-Soriano,
  • Fernando Reche-Lorite and
  • Tesifón Parrón-Carreño

Treatment with interferon-free direct-acting antivirals (DAA) has become the gold standard in chronic hepatitis C virus (HCV) infection. Nevertheless, little research about the metabolic impact of achieving sustained virological response (SVR) is ava...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
7 Citations
4,547 Views
13 Pages

After the events of 9/11, many police-responders developed post-traumatic stress disorder (PTSD) and were potentially vulnerable to developing depression and/or anxiety; in addition, nearly half of police with probable PTSD had comorbid depression an...

(This article belongs to the Section Mental Health)
  • Article
  • Open Access
16 Citations
4,237 Views
11 Pages

Higher Risk of Anxiety and Depression in Women with Adenomyosis as Compared with Those with Uterine Leiomyoma

  • Ni Li,
  • Ming Yuan,
  • Qiuju Li,
  • Miaomiao Ji and ,
  • Xue Jiao and
  • Guoyun Wang
  • + 1 author+ 0 author

The main symptoms of adenomyosis may adversely affect physical and mental health and quality of life (QOL). However, studies are few on this topic. This study evaluated the effect of adenomyosis on anxiety, depression, and QOL. Participants with aden...

(This article belongs to the Special Issue Cracking the Enigma of Adenomyosis)
  • Review
  • Open Access
14 Citations
5,724 Views
19 Pages

There is now considerable evidence that Transient Ischemic Attack (TIA) carries important sequelae beyond the risk of recurrent stroke, particularly with respect to peri-event and post-event cognitive dysfunction and subsequent cognitive decline. The...

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
17 Citations
3,917 Views
19 Pages

Outcome Analysis in Elective Electrical Cardioversion of Atrial Fibrillation Patients: Development and Validation of a Machine Learning Prognostic Model

  • Jean C. Nuñez-Garcia,
  • Antonio Sánchez-Puente,
  • Jesús Sampedro-Gómez,
  • Victor Vicente-Palacios and ,
  • Manuel Jiménez-Navarro,
  • Armando Oterino-Manzanas,
  • Javier Jiménez-Candil,
  • P. Ignacio Dorado-Diaz and
  • Pedro L. Sánchez
  • + 4 authors+ 0 author

Background: The integrated approach to electrical cardioversion (EC) in atrial fibrillation (AF) is complex; candidates can resolve spontaneously while waiting for EC, and post-cardioversion recurrence is high. Thus, it is especially interesting to a...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
1 Citations
2,265 Views
7 Pages

This study aimed to evaluate the correlation between plasma lipocalin-2 (LCN2) levels and myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) seropositivity in patients with optic neuritis. Peripheral blood samples were collected from 19...

(This article belongs to the Section Ophthalmology)
  • Review
  • Open Access
21 Citations
4,701 Views
12 Pages

Hereditary Hemorrhagic Telangiectasia and Arterio-Venous Malformations—From Diagnosis to Therapeutic Challenges

  • Mariana Floria,
  • Elena Diana Năfureanu,
  • Diana-Elena Iov,
  • Oana Sîrbu and ,
  • Mihaela Dranga,
  • Anca Ouatu,
  • Daniela Maria Tănase,
  • Oana Bogdana Bărboi,
  • Vasile Liviu Drug and
  • Mihail Dan Cobzeanu
  • + 5 authors+ 0 author

Hereditary hemorrhagic telangiectasia is a rare autosomal dominant vascular disease defined by the presence of mucosal and cutaneous telangiectasia and visceral arterio-venous malformations. The latter are abnormal capillary-free direct communication...

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
8 Citations
4,011 Views
10 Pages

Acute Pulmonary Artery Thrombosis despite Anticoagulation in Patients with COVID-19 Pneumonia: A Single-Center Retrospective Cohort Study

  • Cristian-Mihail Niculae,
  • Ana-Maria-Jennifer Anghel,
  • Eliza-Daniela Militaru,
  • Laura-Georgiana Tîrlescu and ,
  • Mihai Lazar and
  • Adriana Hristea
  • + 1 author+ 0 author

(1) Background: We aimed to describe the clinical and imaging characteristics of patients diagnosed with pulmonary artery thrombosis (PAT) despite receiving anticoagulation with low-molecular-weight heparin (LMWH). (2) Methods: We retrospectively stu...

(This article belongs to the Topic Fighting against COVID-19: Latest Advances, Challenges and Methodologies)
  • Article
  • Open Access
4 Citations
4,822 Views
10 Pages

Could Stoma Be Avoided after Laparoscopic Low Anterior Resection for Rectal Cancer? Experience with Transanal Tube in 195 Cases

  • Antonio Sciuto,
  • Roberto Peltrini,
  • Federica Andreoli,
  • Andrea Gianmario Di Santo Albini and ,
  • Maria Michela Di Nuzzo,
  • Nello Pirozzi,
  • Marcello Filotico,
  • Federica Lauria,
  • Giuseppe Boccia and
  • Francesco Corcione
  • + 9 authors+ 4 authors

Anastomotic leakage is the most-feared complication of rectal surgery. Transanal devices have been suggested for anastomotic protection as an alternative to defunctioning stoma, although evidence is conflicting, and no single device is widely used in...

(This article belongs to the Special Issue Colorectal Surgery: Current Challenges and Future Perspectives)
  • Article
  • Open Access
  • Best Paper Award
65 Citations
10,616 Views
13 Pages

Efficacy of Tildrakizumab for the Treatment of Difficult-to-Treat Areas: Scalp, Nail, Palmoplantar and Genital Psoriasis

  • Marco Galluzzo,
  • Marina Talamonti,
  • Arnaldo Cioni,
  • Virginia Maffei and ,
  • Ruslana Gaeta Shumak,
  • Lorenzo Tofani,
  • Luca Bianchi and
  • Elena Campione
  • + 3 authors+ 0 author

Tildrakizumab, an IL-23 inhibitor, is effective and safe for the improvement of moderate-to-severe chronic plaque psoriasis. However, little evidence is available on the use of this biologic in psoriasis in difficult-to-treat locations. In this retro...

(This article belongs to the Section Immunology & Rheumatology)
  • Article
  • Open Access
7 Citations
3,227 Views
6 Pages

Peri-Implant Distal Radius Fracture: Proposal of a New Classification

  • Leonardo Stramazzo,
  • Giuseppe Rovere,
  • Alessio Cioffi,
  • Giulio Edoardo Vigni and ,
  • Nicolò Galvano,
  • Antonio D’Arienzo,
  • Giulia Letizia Mauro,
  • Lawrence Camarda and
  • Michele D’Arienzo
  • + 4 authors+ 0 author

A peri-implant fracture near the volar plate of the distal radius represents a rarity and can be associated with a mechanical failure of the devices. A literature review was conducted including all fractures that occurred around a volar wrist plate,...

(This article belongs to the Special Issue Orthopedic Treatment of Diseases and Fractures in Elderly)
  • Review
  • Open Access
21 Citations
5,030 Views
14 Pages

Neoadjuvant Chemo-Immunotherapy for Locally Advanced Non-Small-Cell Lung Cancer: A Review of the Literature

  • Sara Franzi,
  • Giovanni Mattioni,
  • Erika Rijavec,
  • Giorgio Alberto Croci and
  • Davide Tosi

Non-small cell lung cancer accounts for approximately 80–85% of all lung cancers and at present represents the main cause of cancer death among both men and women. To date, surgery represents the cornerstone; nevertheless, around 40% of complet...

(This article belongs to the Special Issue Cancer Management in the Era of Immunotherapy)
  • Article
  • Open Access
6 Citations
3,197 Views
13 Pages

Fetal growth restriction (FGR) is a complication of pregnancy connected with increased risk of intrauterine fetal demise. To increase the diagnostic accuracy, the cerebral placental ratio (CPR) is used. Vitamin D may play a role in the regulation of...

(This article belongs to the Special Issue Fetal Growth: What Is New in the Clinical Research?)

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J. Clin. Med. - ISSN 2077-0383