Neuroendocrine Tumors: Etiology, Diagnosis, and Therapy

Dear Colleagues,

Neuroendocrine neoplasms (NENs) are rare and heterogeneous tumors whose incidence has increased in recent years due to better disease knowledge and improvements in diagnostic tools, particularly endoscopy and nuclear medicine. They frequently arise from the gastro–enteropancreatic (GEP) tract, representing approximately 2% of all malignant tumors of the GEP system.

Given their rarity and clinical and biological heterogeneity, there is an urgent need for standardized guidelines for the proper management of these neoplasms, which should always be referred to tertiary referral centers. Novel research strategies are needed to better define diagnostic and therapeutic algorithms, particularly for some specific subgroup of poorly known tumors, including duodenal NENs and functioning tumors. The cooperation between referral centers and the creation of international disease registries should be encouraged to better understand the biology and the natural history of these neoplasms and to consequently improve their management.

The focus of this Special Issue is to consider the following research aspects of NENs: 1) epidemiology and risk factors to define specific subgroups of patients characterized by dismal prognosis; 2) genomic characterization; 3) innovations in multidisciplinary management in both diagnosis and treatment, including surgery (resection and liver transplant), loco-regional treatments, and medical therapy in adjuvant, neoadjuvant and metastatic settings.

Dr. Roberta Elisa Rossi
Dr. Sara Massironi
Guest Editors

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