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Journal of Clinical Medicine, Volume 11, Issue 15

August-1 2022 - 388 articles

Cover Story: Sex differences in cardiovascular disease (CVD) prevalence, disease presentation, and response to therapy have been well characterized, but the underlying mechanisms are poorly understood. In this review, we discuss how sympathetic nervous system (SNS) hyperactivity, typical of the postmenopausal period in women, and the consequent catecholamine secretion, from the postganglionic sympathetic fibers and the adrenal chromaffin cells, negatively impact β-adrenergic receptor (β1-, β2-, β3, β4-AR) signaling and augment the risk of adverse vascular and cardiac effects. Further, we explore how estrogen or phytoestrogen therapies may impact SNS overactivation, preserving β-ARs responsiveness and density, therefore ameliorating most CVD risk factors. View this paper
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Articles (388)

  • Review
  • Open Access
43 Citations
4,607 Views
21 Pages

Level of Physical Activity in Pregnant Populations from Different Geographic Regions: A Systematic Review

  • Cristina Silva-Jose,
  • Miguel Sánchez-Polán,
  • Rubén Barakat,
  • Javier Gil-Ares and
  • Ignacio Refoyo

8 August 2022

The aim of this study was to examine the level of physical activity during pregnancy in different populations worldwide. An intensive search was carried out from February until May 2021. The inclusion criteria were original studies of healthy pregnan...

  • Article
  • Open Access
3 Citations
6,465 Views
11 Pages

8 August 2022

Background: Flaplessly placed one-piece mini dental implants (MDI) are an option to support maxillary overdentures. Evenly distribution of the implants over the atrophic alveolar process implies a risk of accidental sinus perforation in the posterior...

  • Article
  • Open Access
10 Citations
4,221 Views
14 Pages

Atypical 15q11.2-q13 Deletions and the Prader-Willi Phenotype

  • Lionne N. Grootjen,
  • Alicia F. Juriaans,
  • Gerthe F. Kerkhof and
  • Anita C. S. Hokken-Koelega

8 August 2022

Background: Prader-Willi syndrome (PWS) is a rare genetic disorder resulting from the lack of expression of the PWS region (locus q11-q13) on the paternally derived chromosome 15, as a result of a type I or II paternal deletion (50%), maternal unipar...

  • Article
  • Open Access
3 Citations
2,541 Views
11 Pages

8 August 2022

To distinguish between functional gastrointestinal disorders like irritable bowel syndrome (IBS) and mild small bowel Crohn′s disease (CD) can be a burden. The diagnosis of CD often requires small bowel capsule endoscopy (SBCE). The main goal o...

  • Review
  • Open Access
23 Citations
9,898 Views
15 Pages

8 August 2022

Bleeding irregularities are one of the major reasons for discontinuation of oral contraceptives (OCs), and therefore clinicians need to set expectations during consultations. In this review we provide an overview of bleeding data of recently marketed...

  • Article
  • Open Access
2 Citations
3,855 Views
12 Pages

Association of Meibomian Gland Dysfunction with Oral Statin Use

  • Sun-Kyoung Park,
  • Ji-Hye Lee,
  • Ho-Sik Hwang,
  • Hyun-Seung Kim,
  • Kyung-Do Han and
  • Kyung-Sun Na

8 August 2022

This retrospective cross-sectional study aimed to determine the association of oral statin use, dry eye disease (DED), and meibomian gland dysfunction (MGD). A total of 93 subjects were included and divided into two groups: statin users (n = 45) and...

  • Article
  • Open Access
4 Citations
3,352 Views
10 Pages

Pain Extent Is Not Associated with Sensory-Associated Symptoms, Cognitive or Psychological Variables in COVID-19 Survivors Suffering from Post-COVID Pain

  • César Fernández-de-las-Peñas,
  • Stella Fuensalida-Novo,
  • Ricardo Ortega-Santiago,
  • Juan A. Valera-Calero,
  • Corrado Cescon,
  • Marco Derboni,
  • Vincenzo Giuffrida and
  • Marco Barbero

8 August 2022

We aimed to investigate the relationship between pain extent, as a sign of sensitization, and sensory-related, cognitive and psychological variables in hospitalized COVID-19 survivors with post-COVID pain. One hundred and forty-six (67 males, 79 fema...

  • Review
  • Open Access
36 Citations
8,916 Views
12 Pages

New Era in Systemic Sclerosis Treatment: Recently Approved Therapeutics

  • Satoshi Ebata,
  • Asako Yoshizaki-Ogawa,
  • Shinichi Sato and
  • Ayumi Yoshizaki

8 August 2022

Systemic sclerosis (SSc) is a chronic autoimmune disease with a poor prognosis. Among the various complications of SSc, treatment options for the fibrotic lesions, skin sclerosis, and SSc-associated interstitial lung disease (SSc-ILD) have been limit...

  • Article
  • Open Access
1 Citations
5,047 Views
19 Pages

Anti-Hypertensive Activity of Some Selected Unani Formulations: An Evidence-Based Approach for Verification of Traditional Unani Claims Using LC-MS/MS for the Evaluation of Clinically Relevant Blood Parameters in Laboratory Rats

  • Md. Adil Shaharyar,
  • Rudranil Bhowmik,
  • Obaid Afzal,
  • Abdulmalik S. A. Altamimi,
  • Sami I. Alzarea,
  • Waleed Hassan Almalki,
  • Sk Zeeshan Ali,
  • Pallab Mandal,
  • Avishek Mandal and
  • Mohd Ayoob
  • + 2 authors

8 August 2022

Background: Systemic arterial hypertension, which is associated with an increased risk of cardiovascular disease(CVD), is the most significant modifiable risk factor for mortality and morbidity worldwide. WHO has recognized Unanipathy as an alternate...

  • Review
  • Open Access
5 Citations
3,075 Views
21 Pages

microRNAs in Subarachnoid Hemorrhage (Review of Literature)

  • Marianna Makowska,
  • Beata Smolarz and
  • Hanna Romanowicz

8 August 2022

Recently, many studies have shown that microRNAs (miRNAs) in extracellular bioliquids are strongly associated with subarachnoid hemorrhage (SAH) and its complications. The article presents issues related to the occurrence of subarachnoid hemorrhage (...

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J. Clin. Med. - ISSN 2077-0383