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Journal of Clinical Medicine, Volume 10, Issue 2

January-2 2021 - 207 articles

Cover Story: Endothelial dysfunction is a primary feature of several cardiovascular diseases. Endothelial colony-forming cells (ECFCs) represent a highly proliferative subtype of endothelial progenitor cells (EPCs), which are involved in neovascularization and vascular repair. Statins are known to improve the outcome of cardiovascular diseases via pleiotropic effects. Pravastatin induced effects were reversible by the addition of mevalonate. Pravastatin induces beneficial effects on ECFC function, angiogenic signaling and protein expression. These effects may contribute to understand the pleiotropic function of statins as well as to provide a promising option to improve ECFCs’ condition in cell therapy in order to ameliorate endothelial dysfunction. View this paper
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Articles (207)

  • Article
  • Open Access
12 Citations
3,895 Views
10 Pages

Impella CP Implantation during Cardiopulmonary Resuscitation for Cardiac Arrest: A Multicenter Experience

  • Vassili Panagides,
  • Henrik Vase,
  • Sachin P. Shah,
  • Mir B. Basir,
  • Julien Mancini,
  • Hayaan Kamran,
  • Supria Batra,
  • Marc Laine,
  • Hans Eiskjær and
  • Steffen Christensen
  • + 4 authors

18 January 2021

Background: Impella CP is a left ventricular pump which may serve as a circulatory support during cardiopulmonary resuscitation (CPR) for cardiac arrest (CA). Nevertheless, the survival rate and factors associated with survival in patients undergoing...

  • Article
  • Open Access
21 Citations
4,652 Views
13 Pages

Prevalence of Sarcopenia Employing Population-Specific Cut-Points: Cross-Sectional Data from the Geelong Osteoporosis Study, Australia

  • Sophia X. Sui,
  • Kara L. Holloway-Kew,
  • Natalie K. Hyde,
  • Lana J. Williams,
  • Monica C. Tembo,
  • Sarah Leach and
  • Julie A. Pasco

18 January 2021

Background: Prevalence estimates for sarcopenia vary depending on the ascertainment criteria and thresholds applied. We aimed to estimate the prevalence of sarcopenia using two international definitions but employing Australian population-specific cu...

  • Review
  • Open Access
6 Citations
4,814 Views
10 Pages

18 January 2021

Hepatic encephalopathy (HE) is a form of brain dysfunction that is caused by liver insufficiency and/or portal-systemic shunting. The exact nature of HE is debated; as such, conflicting uses of the term “HE” may cause inconsistencies in i...

  • Article
  • Open Access
4 Citations
3,678 Views
9 Pages

Association between Arthritis and Migraine: A US Nationally Representative Study Including 2649 Adults

  • Louis Jacob,
  • Jae Il Shin,
  • Guillermo F. López-Sánchez,
  • Josep Maria Haro,
  • Ai Koyanagi,
  • Jong Yeob Kim,
  • Jae Han Kim,
  • Hans Oh and
  • Lee Smith

18 January 2021

This study aimed to investigate the cross-sectional association between arthritis and migraine in a large representative sample of the US adult population. The study used data from adults who participated in the RAND American Life Panel (ALP). Arthri...

  • Article
  • Open Access
17 Citations
9,900 Views
23 Pages

A Multi-Modal MRI Analysis of Cortical Structure in Relation to Gender Dysphoria, Sexual Orientation, and Age in Adolescents

  • Malvina N. Skorska,
  • Sofia Chavez,
  • Gabriel A. Devenyi,
  • Raihaan Patel,
  • Lindsey T. Thurston,
  • Meng-Chuan Lai,
  • Kenneth J. Zucker,
  • M. Mallar Chakravarty,
  • Nancy J. Lobaugh and
  • Doug P. VanderLaan

18 January 2021

Gender dysphoria (GD) is characterized by distress due to an incongruence between experienced gender and sex assigned at birth. Sex-differentiated brain regions are hypothesized to reflect the experienced gender in GD and may play a role in sexual or...

  • Article
  • Open Access
123 Citations
4,941 Views
11 Pages

Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study

  • Giovanni Tarantino,
  • Felice Crocetto,
  • Concetta Di Vito,
  • Massimiliano Creta,
  • Raffaele Martino,
  • Savio Domenico Pandolfo,
  • Salvatore Pesce,
  • Luigi Napolitano,
  • Domenico Capone and
  • Ciro Imbimbo

18 January 2021

Among risk factors (apart from smoking) likely involved in bladder cancer (BCa), metabolic syndrome (MS), obesity and type 2 diabetes mellitus (T2DM) have been explored with contrasting results. In spite of these studies, there is little data on the...

  • Registered Report
  • Open Access
2 Citations
1,827 Views
4 Pages

18 January 2021

In seronegative arthritis with extremity edema, the differential diagnosis between remitting seronegative symmetrical synovitis with pitting edema syndrome (RS3PE) and seronegative rheumatoid arthritis (SNRA) is difficult. We compared the clinical ch...

  • Article
  • Open Access
14 Citations
3,391 Views
9 Pages

Early Pregnancy Outcomes in Fresh Versus Deferred Embryo Transfer Cycles for Endometriosis-Associated Infertility: A Retrospective Cohort Study

  • Justin Tan,
  • Maria Cerrillo,
  • Maria Cruz,
  • Gustavo Nardini Cecchino and
  • Juan Antonio Garcia-Velasco

18 January 2021

Given the estrogen-dependence associated with endometriosis, hyper-stimulation associated with assisted reproduction treatment may exacerbate the disease process and adversely affect endometrial receptivity and subsequent implantation. In this way, a...

  • Review
  • Open Access
14 Citations
2,773 Views
11 Pages

18 January 2021

Background: The surgical approach and choice of drainage veins for uterus transplantation living-donor surgery have been investigated to reduce invasiveness. Methods: A thorough search of the PubMed database was conducted. The search was not limited...

  • Article
  • Open Access
15 Citations
4,745 Views
16 Pages

Relation of Dietary Fatty Acids and Vitamin D to the Prevalence of Meibomian Gland Dysfunction in Japanese Adults: The Hirado–Takushima Study

  • Shima Fukuoka,
  • Reiko Arita,
  • Takanori Mizoguchi,
  • Motoko Kawashima,
  • Shizuka Koh,
  • Rika Shirakawa,
  • Takashi Suzuki,
  • Satoshi Sasaki and
  • Naoyuki Morishige

18 January 2021

Intervention studies have shown that n-3 polyunsaturated fatty acid (PUFA) supplementation is effective for the treatment of meibomian gland dysfunction (MGD). Ointment containing an analog of vitamin D has also been found to improve symptoms and sig...

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J. Clin. Med. - ISSN 2077-0383