Early Pregnancy Outcomes in Fresh Versus Deferred Embryo Transfer Cycles for Endometriosis-Associated Infertility: A Retrospective Cohort Study
Abstract
1. Introduction
2. Experimental Section
2.1. Study Design
2.2. Inclusion and Exclusion Criteria
2.3. Ovarian Stimulation and Oocyte Retrieval
2.3.1. Oocyte Insemination
2.3.2. Embryo Culture and Preimplantation Genetic Testing (PGT-A)
2.3.3. Endometrial Preparation and ET
2.3.4. Main Outcomes and Statistical Analysis
3. Results
3.1. Baseline Patient Characteristics
3.2. IVF-ICSI Outcomes in Non-PGT-A Cycles
3.3. Age Stratified IVF-ICSI Outcomes (<35, 35–38, >38) in Non-PGT-A Cycles
3.4. PGT-A Cycles
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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BASELINE CHARACTERISTICS | FRESH-ET (n = 339) | DEFERRED-ET (n = 389) | p-VALUE |
---|---|---|---|
AGE (YEARS) * | 35.5 ± 0.2 | 35.9 ± 0.3 | 0.34 |
BMI (KG/M2) * | 22.2 ± 0.1 | 22.4 ± 0.2 | 0.51 |
DURATION OF INFERTILITY (YEARS) * | 2.8 ± 0.3 | 2.9 ± 0.3 | 0.31 |
OVARIAN RESERVE | |||
AMH (NG/ML) * | 3.4 ± 1.8 | 4.3 ± 2.2 | 0.18 |
AFC * | 7.6 ± 2.7 | 8.9 ± 1.1 | 0.16 |
GRAVIDITY | 0.12 | ||
0 | 91.6% | 91.2% | |
≥1 | 8.4% | 8.8% | |
PARITY | 0.25 | ||
0 | 94.8% | 94.3% | |
≥1 | 5.2% | 5.7% | |
ASSOCIATED MALE INFERTILITY | 3.2% | 2.9% | 0.37 |
ENDOMETRIOSIS I-II STAGE | 37.6% | 39.7% | 0.24 |
ENDOMETRIOSIS III-IV STAGE | 62.4% | 60.3% | 0.17 |
TOTAL DOSES OF FSH (IU) * | 1686 ± 46 | 1673 ± 64 | 0.14 |
TOTAL DOSES OF HMG (IU) * | 1004 ± 95 | 962 ± 121 | 0.47 |
CYCLE OUTCOMES | FRESH-ET (n = 287) | DEFERRED-ET (n = 306) | p-VALUE |
---|---|---|---|
RETRIEVED OOCYTES | 7.4 ± 0.3 | 8.2 ± 0.8 | 0.57 |
MII OOCYTES | 5.6 ± 0.6 | 6.0 ± 0.7 | 0.45 |
FERTILIZATION RATE (%) | 75.2% | 75.1% | 0.81 |
IMPLANTATION RATE | 49.7% | 49.9% | 0.73 |
CLINICAL PREGNANCY RATE | 40.9% | 39.9% | 0.49 |
MISCARRIAGE RATE | 9.4% | 9.9% | 0.63 |
CYCLE OUTCOMES | FRESH-ET | DEFERRED-ET | p-VALUE |
---|---|---|---|
<35 YEARS-OLD | n = 124 | n = 128 | |
RETRIEVED OOCYTES | 10.1 ± 0.7 | 10.5 ± 1.2 | 0.59 |
MII OOCYTES | 7.3 ± 0.5 | 8.1 ± 0.5 | 0.61 |
FERTILIZATION RATE (%) | 78.9% | 79.6% | 0.52 |
IMPLANTATION RATE | 55.8% | 54.9% | 0.45 |
CLINICAL PREGNANCY RATE | 48.6% | 44.2% | 0.08 |
MISCARRIAGE RATE | 7.3% | 8.4% | 0.12 |
35–37 YEARS-OLD | n = 99 | n = 101 | |
RETRIEVED OOCYTES | 8.8 ± 0.7 | 10.2 ± 1.3 | 0.48 |
MII OOCYTES | 6.7 ± 0.5 | 7.8 ± 0.3 | 0.68 |
FERTILIZATION RATE (%) | 74.8% | 73.9% | 0.73 |
IMPLANTATION RATE | 46.8% | 48.2% | 0.45 |
CLINICAL PREGNANCY RATE | 37.2% | 38.7% | 0.48 |
MISCARRIAGE RATE | 8.2% | 9.8% | 0.16 |
>38 YEARS-OLD | n = 64 | n = 77 | |
RETRIEVED OOCYTES | 5.8 ± 0.6 | 6.7 ± 1.2 | 0.41 |
MII OOCYTES | 4.1 ± 0.9 | 4.6 ± 0.8 | 0.24 |
FERTILIZATION RATE (%) | 68.5% | 69.2% | 0.32 |
IMPLANTATION RATE | 42.3% | 43.7% | 0.27 |
CLINICAL PREGNANCY RATE | 31.6% | 34.5% | 0.19 |
MISCARRIAGE RATE | 10.4% | 10.8% | 0.26 |
CYCLE OUTCOMES | FRESH TRANSFER (n = 52) | DEFERRED TRANSFER (n = 83) | p-VALUE |
---|---|---|---|
RETRIEVED OOCYTES | 9.1 ± 1.3 | 8.6 ± 1.6 | 0.46 |
MII OOCYTES | 8.2 ± 0.7 | 7.5 ± 0.9 | 0.14 |
FERTILIZATION RATE (%) | 74.2% | 72.6% | 0.28 |
IMPLANTATION RATE | 45.2% | 46.6% | 0.38 |
CLINICAL PREGNANCY RATE | 43.4% | 45.1% | 0.26 |
MISCARRIAGE RATE | 4.6% | 5.2% | 0.12 |
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Tan, J.; Cerrillo, M.; Cruz, M.; Cecchino, G.N.; Garcia-Velasco, J.A. Early Pregnancy Outcomes in Fresh Versus Deferred Embryo Transfer Cycles for Endometriosis-Associated Infertility: A Retrospective Cohort Study. J. Clin. Med. 2021, 10, 344. https://doi.org/10.3390/jcm10020344
Tan J, Cerrillo M, Cruz M, Cecchino GN, Garcia-Velasco JA. Early Pregnancy Outcomes in Fresh Versus Deferred Embryo Transfer Cycles for Endometriosis-Associated Infertility: A Retrospective Cohort Study. Journal of Clinical Medicine. 2021; 10(2):344. https://doi.org/10.3390/jcm10020344
Chicago/Turabian StyleTan, Justin, Maria Cerrillo, Maria Cruz, Gustavo Nardini Cecchino, and Juan Antonio Garcia-Velasco. 2021. "Early Pregnancy Outcomes in Fresh Versus Deferred Embryo Transfer Cycles for Endometriosis-Associated Infertility: A Retrospective Cohort Study" Journal of Clinical Medicine 10, no. 2: 344. https://doi.org/10.3390/jcm10020344
APA StyleTan, J., Cerrillo, M., Cruz, M., Cecchino, G. N., & Garcia-Velasco, J. A. (2021). Early Pregnancy Outcomes in Fresh Versus Deferred Embryo Transfer Cycles for Endometriosis-Associated Infertility: A Retrospective Cohort Study. Journal of Clinical Medicine, 10(2), 344. https://doi.org/10.3390/jcm10020344