Pathogenesis, Epidemiology and Treatment of Atopic Dermatitis and Psoriasis

Dear Colleagues,

Atopic dermatitis and psoriasis are common inflammatory skin diseases which enormously deteriorate the psycho–physical and socio-economic condition of afflicted patients. Although the epidermal keratinocytes are the major targets, differential immune responses have been found to operate in the pathomechanisms of atopic dermatitis and psoriasis. The recent therapeutic success of specific biologics points a crucial role of IL-13/IL-4 and IL-22 in atopic dermatitis, and TNF-α, IL-23, and IL-17A in psoriasis. These cytokines differentially affect epidermal barrier function, epidermal proliferation, and the inflammatory response of the skin with variable levels of pruritus and scratch injury. As the skin is constantly exposed to the outside atmosphere, a myriad of external stimuli such as ultraviolet rays and environmental chemicals may exacerbate or ameliorate the cytokine-mediated keratinocyte alteration. Thus, the skin barrier, itching, and inflammation are current and future treatment targets for both diseases. We welcome manuscripts on all aspects of atopic dermatitis and psoriasis and would be happy to review your contributions to our Special Issue in the Journal of Clinical Medicine.

Prof. Dr. Masutaka Furue
Guest Editor

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