Next Article in Journal
Familial Multiple Coagulation Factor Deficiencies (FMCFDs) in a Large Cohort of Patients—A Single-Center Experience in Genetic Diagnosis
Previous Article in Journal
Operative and Clinical Outcomes of Minimally Invasive Living-Donor Surgery on Uterus Transplantation: A Literature Review
Previous Article in Special Issue
Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study
Article

Relation of Dietary Fatty Acids and Vitamin D to the Prevalence of Meibomian Gland Dysfunction in Japanese Adults: The Hirado–Takushima Study

1
Lid and Meibomian Gland Working Group (LIME), 626-11 Minami-Nakano, Minumaku, Saitama 337-0042, Japan
2
Omiya Hamada Eye Clinic, 1-169-1 Sakuragicho, Omiyaku, Saitama 330-0854, Japan
3
Department of Ophthalmology, The University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan
4
Department of Ophthalmology, Itoh Clinic, 626-11 Minami-Nakano, Minumaku, Saitama 337-0042, Japan
5
Mizoguchi Eye Clinic, 6-13 Tawaramachi, Sasebo, Nagasaki 857-0016, Japan
6
Department of Ophthalmology, Keio University, 35 Shinanomachi, Shinjukuku, Tokyo 160-8582, Japan
7
Department of Ophthalmology, Osaka University, 2-15 Yamadaoka, Suita 565-0871, Japan
8
Department of Ophthalmology, Toho University Omori Medical Center, 6-11-1 Omorinishi, Otaku, Tokyo 143-8541, Japan
9
Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-0033, Japan
10
Division of Cornea and Ocular Surface, Ohshima Eye Hospital 11-8 Kamigofukumachi, Hakataku, Fukuoka 812-0036, Japan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(2), 350; https://doi.org/10.3390/jcm10020350
Received: 1 December 2020 / Revised: 29 December 2020 / Accepted: 14 January 2021 / Published: 18 January 2021
(This article belongs to the Special Issue Cutting-Edge Topics in Dry Eye Disease)
Intervention studies have shown that n-3 polyunsaturated fatty acid (PUFA) supplementation is effective for the treatment of meibomian gland dysfunction (MGD). Ointment containing an analog of vitamin D has also been found to improve symptoms and signs of MGD. We have now evaluated the relation of MGD prevalence to dietary intake of fatty acids (FAs) and vitamin D among a Japanese population. Subjects comprised 300 adults aged 20 to 92 years residing on Takushima Island. MGD was diagnosed on the basis of subjective symptoms, lid margin abnormalities, and meibomian gland obstruction. Dietary FA and vitamin D intake was estimated with a brief-type self-administered diet history questionnaire. MGD prevalence was 35.3%. Multivariate adjusted odds ratios (95% confidence intervals) between extreme quintiles of intake for MGD prevalence were 0.40 (0.16–0.97) for total fat, 0.40 (0.17–0.97) for saturated FAs, 0.40 (0.17–0.97) for oleic acid, 0.52 (0.23–1.18) for n-3 PUFAs, 0.63 (0.27–1.49) for n-6 PUFAs, 1.32 (0.59–2.95) for the n-6/n-3 PUFA ratio, and 0.38 (0.17–0.87) for vitamin D. Total fat, saturated FA, oleic acid, and vitamin D intake may thus be negatively associated with MGD prevalence in the Japanese. View Full-Text
Keywords: fatty acids; vitamin D; meibomian gland dysfunction; brief-type self-administered diet history questionnaire; Japanese fatty acids; vitamin D; meibomian gland dysfunction; brief-type self-administered diet history questionnaire; Japanese
Show Figures

Figure 1

MDPI and ACS Style

Fukuoka, S.; Arita, R.; Mizoguchi, T.; Kawashima, M.; Koh, S.; Shirakawa, R.; Suzuki, T.; Sasaki, S.; Morishige, N. Relation of Dietary Fatty Acids and Vitamin D to the Prevalence of Meibomian Gland Dysfunction in Japanese Adults: The Hirado–Takushima Study. J. Clin. Med. 2021, 10, 350. https://doi.org/10.3390/jcm10020350

AMA Style

Fukuoka S, Arita R, Mizoguchi T, Kawashima M, Koh S, Shirakawa R, Suzuki T, Sasaki S, Morishige N. Relation of Dietary Fatty Acids and Vitamin D to the Prevalence of Meibomian Gland Dysfunction in Japanese Adults: The Hirado–Takushima Study. Journal of Clinical Medicine. 2021; 10(2):350. https://doi.org/10.3390/jcm10020350

Chicago/Turabian Style

Fukuoka, Shima, Reiko Arita, Takanori Mizoguchi, Motoko Kawashima, Shizuka Koh, Rika Shirakawa, Takashi Suzuki, Satoshi Sasaki, and Naoyuki Morishige. 2021. "Relation of Dietary Fatty Acids and Vitamin D to the Prevalence of Meibomian Gland Dysfunction in Japanese Adults: The Hirado–Takushima Study" Journal of Clinical Medicine 10, no. 2: 350. https://doi.org/10.3390/jcm10020350

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop