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Journal of Clinical Medicine, Volume 10, Issue 3

February-1 2021 - 182 articles

Cover Story: Ventricular assist device (VAD)-specific infections, in particular, driveline infections, are a concerning complication of VAD implantation that often results in significant morbidity and even mortality. The presence of a percutaneous driveline at the skin exit-site and in the subcutaneous tunnel allows biofilm formation and migration by many bacterial and fungal pathogens. Biofilm formation is an important microbial strategy, providing a shield against antimicrobial treatment and human immune responses; biofilm migration facilitates the extension of infection to deeper tissues such as the pump pocket and the bloodstream. The purpose of this review is to improve the understanding of VAD-specific infections, from basic “bench” knowledge to clinical “bedside” experience, with a specific focus on the role of biofilms in driveline infections. View this paper
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Articles (182)

  • Article
  • Open Access
12 Citations
9,782 Views
14 Pages

Development of a Single-Step Antibody–Drug Conjugate Purification Process with Membrane Chromatography

  • Juan Carlos Cordova,
  • Sheng Sun,
  • Jeffrey Bos,
  • Srinath Thirumalairajan,
  • Sanjeevani Ghone,
  • Miyako Hirai,
  • Ricarda A. Busse,
  • Julia S. v. der Hardt,
  • Ian Schwartz and
  • Jieyu Zhou

2 February 2021

Membrane chromatography is routinely used to remove host cell proteins, viral particles, and aggregates during antibody downstream processing. The application of membrane chromatography to the field of antibody-drug conjugates (ADCs) has been applied...

  • Article
  • Open Access
5 Citations
3,388 Views
13 Pages

Trends and Clinical Impact of Gastrointestinal Endoscopic Procedures on Acute Heart Failure in Spain (2002–2017)

  • Manuel Méndez-Bailón,
  • Rodrigo Jiménez-García,
  • Nuria Muñoz-Rivas,
  • Valentín Hernández-Barrera,
  • José Maria de Miguel-Yanes,
  • Javier de Miguel-Díez,
  • Emmanuel Andrès,
  • Noel Lorenzo-Villalba and
  • Ana López-de-Andrés

2 February 2021

Introduction: Heart failure decompensation can be triggered by many factors, including anemia. In cases of iron deficiency anemia or iron deficiency without anemia, endoscopic studies are recommended to rule out the presence of gastrointestinal neopl...

  • Article
  • Open Access
27 Citations
6,498 Views
13 Pages

Low-Intensity Resistance Training with Moderate Blood Flow Restriction Appears Safe and Increases Skeletal Muscle Strength and Size in Cardiovascular Surgery Patients: A Pilot Study

  • Hironaga Ogawa,
  • Toshiaki Nakajima,
  • Ikuko Shibasaki,
  • Takahisa Nasuno,
  • Hiroyuki Kaneda,
  • Satoshi Katayanagi,
  • Hayato Ishizaka,
  • Yuta Mizushima,
  • Azusa Uematsu and
  • Tomohiro Yasuda
  • + 6 authors

2 February 2021

We examined the safety and the effects of low-intensity resistance training (RT) with moderate blood flow restriction (KAATSU RT) on muscle strength and size in patients early after cardiac surgery. Cardiac patients (age 69.6 ± 12.6 years, n = 21, M...

  • Article
  • Open Access
2 Citations
3,720 Views
9 Pages

2 February 2021

(1) Background: During the COVID-19 pandemic, shortages in the supply of personal protective equipment (PPE) have become apparent. The idea of using commonly available full-face diving (FFD) masks as a temporary solution was quickly spread across soc...

  • Review
  • Open Access
25 Citations
4,449 Views
15 Pages

2 February 2021

Hepatitis C virus (HCV) is a major cause of death and morbidity globally and is a leading cause of hepatocellular carcinoma (HCC). Incidence of HCV infections, as well as HCV-related liver diseases, are increasing. Although now, with new direct actin...

  • Review
  • Open Access
13 Citations
3,903 Views
14 Pages

Mid-Regional Proadrenomedullin as a New Biomarker of Kidney and Cardiovascular Diseases—Is It the Future?

  • Katarzyna Czajkowska,
  • Edyta Zbroch,
  • Angelika Bielach-Bazyluk,
  • Katarzyna Mitrosz,
  • Elzbieta Bujno,
  • Katarzyna Kakareko,
  • Alicja Rydzewska-Rosolowska and
  • Tomasz Hryszko

2 February 2021

The increasing prevalence of cardiovascular disease and concomitant chronic kidney disease among the aging populations is responsible for considerable growth of mortality. Additionally, frequent, prolonged hospitalizations and long-term treatment gen...

  • Article
  • Open Access
3 Citations
4,307 Views
12 Pages

Age Differences in Motor Recruitment Patterns of the Shoulder in Dynamic and Isometric Contractions. A Cross-Sectional Study

  • Cristina Lirio-Romero,
  • Rocío Palomo-Carrión,
  • Helena Romay-Barrero,
  • Asunción Ferri-Morales,
  • Virginia Prieto-Gómez and
  • María Torres-Lacomba

2 February 2021

Aging processes in the musculoskeletal system lead to functional impairments that restrict participation. Purpose: To assess differences in the force and motor recruitment patterns of shoulder muscles between age groups to understand functional disor...

  • Article
  • Open Access
3 Citations
3,548 Views
21 Pages

Sulfatase 2 Is Associated with Steroid Resistance in Childhood Nephrotic Syndrome

  • Shipra Agrawal,
  • Richard F. Ransom,
  • Saras Saraswathi,
  • Esperanza Garcia-Gonzalo,
  • Amy Webb,
  • Juan L. Fernandez-Martinez,
  • Milan Popovic,
  • Adam J. Guess,
  • Andrzej Kloczkowski and
  • Rainer Benndorf
  • + 3 authors

2 February 2021

Glucocorticoid (GC) resistance complicates the treatment of ~10–20% of children with nephrotic syndrome (NS), yet the molecular basis for resistance remains unclear. We used RNAseq analysis and in silico algorithm-based approaches on peripheral blood...

  • Article
  • Open Access
38 Citations
5,771 Views
14 Pages

2 February 2021

Introduction: The most important factor which is responsible for the positive course of implant treatment is the process of osseointegration between the implant structure and the host’s bone tissue. The aim of this study was to assess what effect the...

  • Article
  • Open Access
17 Citations
7,344 Views
8 Pages

Impact of 1-Hour Bundle Achievement in Septic Shock

  • Byuk Sung Ko,
  • Sung-Hyuk Choi,
  • Tae Gun Shin,
  • Kyuseok Kim,
  • You Hwan Jo,
  • Seung Mok Ryoo,
  • Yoo Seok Park,
  • Woon Yong Kwon,
  • Han Sung Choi and
  • Sung Phil Chung
  • + 5 authors

2 February 2021

This study aimed to address the impact of 1-hr bundle achievement on outcomes in septic shock patients. Secondary analysis of multicenter prospectively collected data on septic shock patients who had undergone protocolized resuscitation bundle therap...

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J. Clin. Med. - ISSN 2077-0383