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Dermatological Manifestations in Inflammatory Bowel Diseases

Gastroenterology Section, Perugia General Hospital, 06156 Perugia, Italy
Gastroenterology & Hepatology Section, Department of Medicine, University of Perugia, 06156 Perugia, Italy
Dermatology Section, Department of Medicine, University of Perugia, 06156 Perugia, Italy
Gastroenterology Unit, Department of Biomedical and Clinical Sciences, “L.Sacco” Hospital, 20157 Milano, Italy
Dermatology Unit, Fondazione IRCSS Cà Granda, Ospedale Maggiore Policlinico, 20122 Milano, Italy
Department of Pathophysiology and Transplantation, University of Milano, 20122 Milano, Italy
Author to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(2), 364;
Received: 11 December 2020 / Revised: 4 January 2021 / Accepted: 6 January 2021 / Published: 19 January 2021
(This article belongs to the Special Issue Chronic Inflammatory Skin Diseases: An Update for Clinician)
Inflammatory bowel diseases (IBDs) may be associated with extra-intestinal manifestations. Among these, mucocutaneous manifestations are relatively frequent, often difficult to diagnose and treat, and may complicate the course of the underlying disease. In the present review, a summary of the most relevant literature on the dermatologic manifestations occurring in patients with inflammatory bowel diseases has been reviewed. The following dermatological manifestations associated with IBDs have been identified: (i) specific manifestations with the same histological features of the underlying IBD (occurring only in Crohn’s disease); (ii) cutaneous disorders associated with IBDs (such as aphthous stomatitis, erythema nodosum, psoriasis, epidermolysis bullosa acquisita); (iii) reactive mucocutaneous manifestations of IBDs (such as pyoderma gangrenosum, Sweet’s syndrome, bowel-associated dermatosis-arthritis syndrome, aseptic abscess ulcers, pyodermatitis–pyostomatitis vegetans, etc.); (iv) mucocutaneous conditions secondary to treatment (including injection site reactions, infusion reactions, paradoxical reactions, eczematous and psoriasis-like reactions, cutaneous infections, and cutaneous malignancies); (v) manifestations due to nutritional malabsorption (such as stomatitis, glossitis, angular cheilitis, pellagra, scurvy, purpura, acrodermatitis enteropathica, phrynoderma, seborrheic-type dermatitis, hair and nail abnormalities). An accurate dermatological examination is essential in all IBD patients, especially in candidates to biologic therapies, in whom drug-induced cutaneous reactions may assume marked clinical relevance. View Full-Text
Keywords: Crohn’s disease; dermatological manifestations; inflammatory bowel disease; skin; ulcerative colitis Crohn’s disease; dermatological manifestations; inflammatory bowel disease; skin; ulcerative colitis
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MDPI and ACS Style

Antonelli, E.; Bassotti, G.; Tramontana, M.; Hansel, K.; Stingeni, L.; Ardizzone, S.; Genovese, G.; Marzano, A.V.; Maconi, G. Dermatological Manifestations in Inflammatory Bowel Diseases. J. Clin. Med. 2021, 10, 364.

AMA Style

Antonelli E, Bassotti G, Tramontana M, Hansel K, Stingeni L, Ardizzone S, Genovese G, Marzano AV, Maconi G. Dermatological Manifestations in Inflammatory Bowel Diseases. Journal of Clinical Medicine. 2021; 10(2):364.

Chicago/Turabian Style

Antonelli, Elisabetta, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo V. Marzano, and Giovanni Maconi. 2021. "Dermatological Manifestations in Inflammatory Bowel Diseases" Journal of Clinical Medicine 10, no. 2: 364.

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