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Journal of Clinical Medicine, Volume 10, Issue 2

January-2 2021 - 207 articles

Cover Story: Endothelial dysfunction is a primary feature of several cardiovascular diseases. Endothelial colony-forming cells (ECFCs) represent a highly proliferative subtype of endothelial progenitor cells (EPCs), which are involved in neovascularization and vascular repair. Statins are known to improve the outcome of cardiovascular diseases via pleiotropic effects. Pravastatin induced effects were reversible by the addition of mevalonate. Pravastatin induces beneficial effects on ECFC function, angiogenic signaling and protein expression. These effects may contribute to understand the pleiotropic function of statins as well as to provide a promising option to improve ECFCs’ condition in cell therapy in order to ameliorate endothelial dysfunction. View this paper
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Articles (207)

  • Article
  • Open Access
10 Citations
3,390 Views
14 Pages

Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura

  • Tanja Falter,
  • Sibylle Böschen,
  • Markus Schepers,
  • Manfred Beutel,
  • Karl Lackner,
  • Inge Scharrer and
  • Bernhard Lämmle

19 January 2021

Autoimmune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening, relapsing disease in which an acquired deficiency of the enzyme ADAMTS13 leads to generalised microvascular thrombosis. Survivors have a high prevalence of depression and im...

  • Review
  • Open Access
26 Citations
9,102 Views
23 Pages

19 January 2021

Chromodomain Helicase DNA-binding 8 (CHD8) is a high confidence risk factor for autism spectrum disorders (ASDs) and the genetic cause of a distinct neurodevelopmental syndrome with the core symptoms of autism, macrocephaly, and facial dysmorphism. T...

  • Article
  • Open Access
2 Citations
2,898 Views
14 Pages

Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with ST-Segment Elevation Myocardial Infarction Based on Pre-Percutaneous Coronary Intervention Thrombolysis in Myocardial Infarction Flow Grade

  • Yong Hoon Kim,
  • Ae-Young Her,
  • Myung Ho Jeong,
  • Byeong-Keuk Kim,
  • Sung-Jin Hong,
  • Seunghwan Kim,
  • Chul-Min Ahn,
  • Jung-Sun Kim,
  • Young-Guk Ko and
  • Donghoon Choi
  • + 2 authors

19 January 2021

This study aims to investigate the two-year clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DES) based on pre-percutaneous coronary intervention (PCI) thrombolysis in myocardial infarction (TIMI) flow g...

  • Article
  • Open Access
13 Citations
10,449 Views
12 Pages

19 January 2021

Non-controlled hemorrhage with accompanying trauma-induced coagulopathy (TIC) remains the most common cause of preventable death after multiple injury. Rapid identification followed by aggressive treatment is the key for improved outcomes. Treatment...

  • Article
  • Open Access
20 Citations
3,758 Views
14 Pages

Changes in Cartilage Thickness and Denuded Bone Area after Knee Joint Distraction and High Tibial Osteotomy—Post-Hoc Analyses of Two Randomized Controlled Trials

  • Mylène P. Jansen,
  • Susanne Maschek,
  • Ronald J. van Heerwaarden,
  • Simon C. Mastbergen,
  • Wolfgang Wirth,
  • Floris P. J. G. Lafeber and
  • Felix Eckstein

19 January 2021

High tibial osteotomy (HTO) and knee joint distraction (KJD) are joint-preserving treatments that unload the more affected compartment (MAC) in knee osteoarthritis. This post-hoc study compares two-year cartilage-thickness changes after treatment wit...

  • Article
  • Open Access
9 Citations
3,752 Views
11 Pages

The Association between Serum Hemoglobin and Renal Prognosis of IgA Nephropathy

  • Tae Ryom Oh,
  • Su Hyun Song,
  • Hong Sang Choi,
  • Chang Seong Kim,
  • Seung Hyeok Han,
  • Kyung Pyo Kang,
  • Young Joo Kwon,
  • Soo Wan Kim,
  • Seong Kwon Ma and
  • Eun Hui Bae

19 January 2021

Immunoglobin A (IgA) nephropathy causes chronic kidney disease worldwide. Therefore, identifying risk factors associated with the progression of IgA nephropathy is crucial. Anemia is a common complication of chronic kidney disease; however, few studi...

  • Article
  • Open Access
20 Citations
5,551 Views
14 Pages

Thyroid Autoimmune Disease—Impact on Sexual Function in Young Women

  • Ana-Maria Cristina Bortun,
  • Viviana Ivan,
  • Dan-Bogdan Navolan,
  • Liana Dehelean,
  • Andreea Borlea and
  • Dana Stoian

19 January 2021

The important prevalence of autoimmune thyroid disease (AITD) in the general population was the main motivation for conducting the present study. The present paper aims to estimate the possible comorbidities related to female sexual dysfunction (FSD)...

  • Erratum
  • Open Access
1 Citations
2,514 Views
2 Pages

Erratum: Iyer, A., et al. Integrative Analysis and Machine Learning Based Characterization of Single Circulating Tumor Cells. J. Clin. Med. 2020, 9, 1206

  • Arvind Iyer,
  • Krishan Gupta,
  • Shreya Sharma,
  • Kishore Hari,
  • Yi Fang Lee,
  • Neevan Ramalingam,
  • Yoon Sim Yap,
  • Jay West,
  • Ali Asgar Bhagat and
  • Balaram Vishnu Subramani
  • + 6 authors

19 January 2021

In the published manuscript [...]

  • Article
  • Open Access
21 Citations
6,005 Views
25 Pages

Surgical Treatment of Diabetic Foot Ulcers Complicated by Osteomyelitis with Gentamicin-Loaded Calcium Sulphate-Hydroxyapatite Biocomposite

  • Kor H. Hutting,
  • Wouter B. aan de Stegge,
  • Jaap J. van Netten,
  • Wouter A. ten Cate,
  • Luuk Smeets,
  • Gijs M. J. M. Welten,
  • Dick M. Scharn,
  • Jean-Paul P. M. de Vries and
  • Jeff G. van Baal

19 January 2021

Diabetic foot ulcers, complicated by osteomyelitis, can be treated by surgical resection, dead space filling with gentamicin-loaded calcium sulphate-hydroxyapatite (CaS-HA) biocomposite, and closure of soft tissues and skin. To assess the feasibility...

  • Article
  • Open Access
8 Citations
4,626 Views
9 Pages

Intercostal Catheters for Postoperative Pain Management in VATS Reduce Opioid Consumption

  • Florian Ponholzer,
  • Caecilia Ng,
  • Herbert Maier,
  • Hannes Dejaco,
  • Andreas Schlager,
  • Paolo Lucciarini,
  • Dietmar Öfner and
  • Florian Augustin

19 January 2021

Background: Postoperative pain after video-assisted thoracoscopic surgery (VATS) affects patients’ recovery, postoperative complications, and length of stay (LOS). Despite its relevance, there are no guidelines on optimal perioperative pain man...

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J. Clin. Med. - ISSN 2077-0383