Vaccines, Volume 7, Issue 3
2019 September - 65 articles
Cover Story: Zika is a flavivirus similar to Dengue and, usually, both viruses are found to co-circulate and are transmitted by mosquitoes bites. In addition, Zika virus is transmitted by the maternal–fetal route, and fetal infections are associated with microcephaly and other neurological complications in newborns. A major issue with Zika virus vaccines, is their potential to induce antibodies that not only fail to neutralize the virus but also enhance infection. EDIII, the third domain of the envelope protein (E), is known to specifically induce neutralizing rather than enhancing antibodies. Thus, we generated a Zika virus vaccine-candidate based on the EDIII domain displayed in the immunologically optimized cucumber mosaic virus-derived virus-like particles (VLPs) and exhibit the induction of Zika virus-neutralizing antibodies without enhancing infection by Dengue virus. View this paper
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Vaccines - ISSN 2076-393X