Vaccines, Volume 13, Issue 9
2025 September - 104 articles
Cover Story: Non-typeable Haemophilus influenzae (NTHi) can cause local infections and invasive diseases such as meningitis and septicemia but vaccines are still lacking. Since these isolates lack a capsule, vaccines should target outer membrane proteins (OMPs). Whole genome sequencing of 1144 H. influenzae genomes identified 514 conserved among all these isolates. We focused on two: OMP5 (P5) and OMP26 (P26). Both proteins are involved in virulence of NTHi. Our findings show that purified, cloned P5 and P26 proteins are immunogenic during human infections. In mice, combined immunization with these proteins conferred both passive and active protection against homologous and heterologous NTHi isolates, indicating potential broad cross-protection. View this paper
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Vaccines - ISSN 2076-393X