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Vaccines, Volume 11, Issue 7

July 2023 - 149 articles

Cover Story: Patients with chronic pulmonary diseases, such as cystic fibrosis, are prone to developing chronic lung bacterial infections. Since the complex clinical picture of these individuals may include infections of Burkholderia cepacia complex, Haemophilus influenzae, Mycobacterium abscessus complex, Pseudomonas aeruginosa and Staphylococcus aureus, which are complicated to treat, prevention remains the best strategy. An effective approach for prevention is to develop a broad-spectrum vaccine using proteins that are well conserved across different species. In this context, reverse vaccinology, a method based on the computational analysis of the genome of various microorganisms for the identification of the most attractive epitopes, appears as one of the most promising tools for the identification of putative targets for broad-spectrum vaccine development. View this paper
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Vaccines - ISSN 2076-393X