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Vaccines, Volume 7, Issue 4 (December 2019) – 96 articles
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Cover Story (view full-size image) A novel semisynthetic archaeosome formulation, sulfated S-lactosylarchaeol (SLA), has strong [...] Read more. A novel semisynthetic archaeosome formulation, sulfated S-lactosylarchaeol (SLA), has strong immunostimulatory activity for the induction of antigen-specific immunity following systemic immunization. We evaluated SLA archaeosome formulations as an adjuvant to the E1/E2 HCV envelope protein in a murine model and compared antigen-specific humoral and cellular responses to those generated with mimetics of commercial adjuvants. Overall, we show that the strength and longevity of anti-HCV responses can be influenced by adjuvant selection. In particular, the simple admixed SLA archaeosome formulation generated strong levels of HCV neutralizing antibodies and polyfunctional antigen-specific CD4 T cells, producing multiple cytokines. View this paper