Current Flavivirus Research Important for Vaccine Development

Dear Colleagues,

Climate change, rising populations, and increases in global travel have led to the emergence of a broad array of pathogenic human flavivirus, including Dengue (DENV), Japanese encephalitis (JEV), Rocio (ROCV), Spondweni (SPOV), Tick Borne encephalitis (TBE), Usutu (USUV), West Nile (WNV) yellow fever (YFV), and the Zika (ZIKV) virus. Individually and in combination these viruses are an increasing threat to global health and economic stability with billions of individuals exposed each year.

Vaccinations are one of the most effective interventions to improve public health by reducing infection rate, complications, and death. To establish the scientific foundation for effective vaccine development, several core factors must be defined, including the fundamental mechanisms of disease, correlates of protection, and the natural history of disease. Vaccine approaches then require further adaption for special populations, such as children, the elderly, and the obese. These are the challenges facing virologists and immunologist working toward the development of effective vaccines for flaviviruses.

Dr. James D. Brien
Dr. Amelia K. Pinto
Guest Editors

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