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Article

A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations

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SaBio. Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC-UCLM-JCCM), Ronda de Toledo 12, 13071 Ciudad Real, Spain
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Sabiotec, S.A. Ed., Polivalente UCLM, Camino de Moledores, 13005 Ciudad Real, Spain
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UMR BIPAR, INRA, Ecole Nationale Vétérinaire d´Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France
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Department of Infectious Diseases and Public Health, City University of Hong Kong, Kowloon, Hong Kong SAR, China
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Department of Applied Sciences, Faculty of Health & Life Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK
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St George’s International School of Medicine, Keith B. Taylor Global Scholars Program, Northumbria University, Newcastle NE1 8ST, UK
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Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, 30559 Hannover, Germany
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Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, UK
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Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078-2007 USA
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Biochemistry Section, Faculty of Science and Chemical Technologies, and Regional Centre for Biomedical Research [CRIB], University of Castilla-La Mancha, 13071 Ciudad Real, Spain
*
Authors to whom correspondence should be addressed.
Vaccines 2019, 7(4), 190; https://doi.org/10.3390/vaccines7040190
Received: 9 October 2019 / Revised: 7 November 2019 / Accepted: 15 November 2019 / Published: 20 November 2019
The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. Rhipicephalus microplus Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens for the PRM control. View Full-Text
Keywords: Dermanyssus; poultry red mite; proteomics; vaccine; vaccinology; control; protective antigens Dermanyssus; poultry red mite; proteomics; vaccine; vaccinology; control; protective antigens
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MDPI and ACS Style

Lima-Barbero, J.F.; Contreras, M.; Mateos-Hernández, L.; Mata-Lorenzo, F.M.; Triguero-Ocaña, R.; Sparagano, O.; Finn, R.D.; Strube, C.; Price, D.R.G.; Nunn, F.; Bartley, K.; Höfle, U.; Boadella, M.; Nisbet, A.J.; de la Fuente, J.; Villar, M. A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations. Vaccines 2019, 7, 190. https://doi.org/10.3390/vaccines7040190

AMA Style

Lima-Barbero JF, Contreras M, Mateos-Hernández L, Mata-Lorenzo FM, Triguero-Ocaña R, Sparagano O, Finn RD, Strube C, Price DRG, Nunn F, Bartley K, Höfle U, Boadella M, Nisbet AJ, de la Fuente J, Villar M. A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations. Vaccines. 2019; 7(4):190. https://doi.org/10.3390/vaccines7040190

Chicago/Turabian Style

Lima-Barbero, José F., Marinela Contreras, Lourdes Mateos-Hernández, Francisco M. Mata-Lorenzo, Roxana Triguero-Ocaña, Olivier Sparagano, Robert D. Finn, Christina Strube, Daniel R.G. Price, Francesca Nunn, Kathryn Bartley, Ursula Höfle, Mariana Boadella, Alasdair J. Nisbet, José de la Fuente, and Margarita Villar. 2019. "A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations" Vaccines 7, no. 4: 190. https://doi.org/10.3390/vaccines7040190

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